Infectious Mononucleosis

Shurin, Susan B.

doi:10.1016/s0031-3955(16)33708-7

Cited by 20 publications

(10 citation statements)

References 42 publications

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“…In patients with EBV, ITP may be triggered by the virus. Mild thrombocytopenia is present in approximately 50% of patients with acute EBV [19], but is thought to be due to pooling in an enlarged spleen [20]. However, the occurrence of marked immune-mediated thrombocytopenia is well described and anti-platelet antibodies have been documented [3].…”

Section: Discussionmentioning

confidence: 99%

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Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura

Kees-Folts

Abt

Domen

et al. 2002

Pediatric Nephrology

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Idiopathic thrombocytopenic purpura (ITP) is a disorder of rapid destruction of antibody-coated platelets. Anti-D immune globulin has been used for treatment of ITP in the United States since 1995. Initial studies identified no significant side effects of treatment. However, a recent report highlighted occasional episodes of intravascular hemolysis after anti-D immune globulin. We describe two children with ITP who developed acute renal failure (ARF) after treatment with anti-D immune globulin and also analyze ten additional cases of ARF reported to the manufacturer, Cangene Corporation, through postmarketing surveillance. All episodes of ARF were associated with intravascular hemolysis. Four patients required dialysis. Patient age ranged from 1 to 82 years, but those requiring dialysis were all under age 15 years. Several patients with ARF had preexisting creatinine elevation. Three of the patients with ARF had serologic evidence of acute Epstein-Barr virus (EBV) infection. Renal biopsy in one patient showed acute tubular necrosis, with findings consistent with pigment nephropathy. Anti-D immune globulin, used to treat ITP, may be associated with intravascular hemolysis and resultant ARF. Renal function should be monitored in patients with evidence of intravascular hemolysis. Children and adolescents may have increased risk of ARF requiring dialysis.

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Section: Discussionmentioning

confidence: 99%

“…In patient 1, intratubular myoglobin was demonstrated on renal biopsy. Hemolysis [20] and rhabdomyolysis [21] are also reported complications of EBV infection. Both of our patients had laboratory evidence of low-grade rhabdomyolysis.…”

Section: Discussionmentioning

confidence: 99%

Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura

Kees-Folts

Abt

Domen

et al. 2002

Pediatric Nephrology

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“…In addition, children at 0–6 y have a high incidence of pneumonia in China ( Oumei et al., 2018 ), thus the reason for bronchitis/pneumonia complicated with IM cannot be confirmed easily. Hepatic dysfunction is the main complication in 7–12 and 13–18 years old groups and is mostly considered to be reversible and may be only related to the severity of the condition ( Fernbach and Starling, 1972 ; Shurin, 1979 ).…”

Section: Discussionmentioning

confidence: 99%

“…It is a human lymphotropic herpes virus, belonging to the family Herpesviridae , genus Lymphocryptovirus , γ-subfamily ( Odumade et al., 2011 ). In 1968, EBV was confirmed to be associated with infectious mononucleosis (IM) ( Shurin, 1979 ). EBV is mainly transmitted through saliva, blood transfusion, and organ transplantation ( Dunmire et al., 2015 , 2018 ; Lennon et al., 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study

Liu¹,

Wang²,

Zhang³

et al. 2022

Virologica Sinica

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“…In the present case it can not be determined whether thrombocytopenia and granulocytopenia were attributed to EBY infection or hypersplenism because marked splenomegaly had 'been present throughout the clinical course. Subclinical evidence of hepatitis with elevation of transarninases and bilirubin is frequently found in patients with EBY infection, although clinical hepatitis with jaundice occurs relatively rarely in these patients (3,5). The pathology of hepatitis in EBY infection is periportal lymphoid infiltration and relatively slight changes in the hepatic cells with no change in hepatic architecture (3,6,7).…”

Section: Discussionmentioning

confidence: 99%

Chronic Hepatitis Associated with Epstein‐Barr Virus Infection in an Infant

Tanaka,

Shimada,

Sasahara

et al. 1986

J. pediatr. gastroenterol. nutr.

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Summary: A 1‐year‐old infant girl had a chronic illness characterized by persistent intermittent fever, thrombocytopenia, granulocytopenia, and marked hepatosplenomegaly. Histological findings on liver biopsy 307 days after the onset of her illness disclosed marked mononuclear cell infiltration and moderate fibrosis in the portal and perilobular areas. Interferon‐therapy induced no clinical and laboratory improvement, whereas the patient's clinical and biochemical findings responded to prednisone. Although these findings suggested a possible autoimmune mechanism, there were no significant findings in extensive immunological and serological tests consistent with autoimmune disease. The profile of antibodies to Epstein‐Barr virus (EBV)‐specific antigens in the patient demonstrated that this prolonged atypical illness was the result of persistent EBV infection.

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Infectious Mononucleosis

Cited by 20 publications

References 42 publications

Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura

Renal failure after anti-D globulin treatment of idiopathic thrombocytopenic purpura

Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China: A nationwide retrospective study

Chronic Hepatitis Associated with Epstein‐Barr Virus Infection in an Infant

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