Infectious mononucleosis and multiple sclerosis – Updated review on associated risk

Sheik-Ali, Sharaf

doi:10.1016/j.msard.2017.02.019

Cited by 30 publications

(17 citation statements)

References 1 publication

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“…Of all viruses considered in MS pathogenesis, EBV, a highly B cell-tropic virus, is the best-studied (Table 1). Defective control of EBV is associated with infectious mononucleosis (IM) in addition to Hodgkin's lymphoma, Burkitt's lymphoma, gastric cancer, nasopharyngeal carcinoma, and conditions associated with HIV, such as hairy cell leukemia and other lymphomas [11,12]. There is also evidence that infection with EBV and associations with transcription factors, implicating EBV nuclear antigen 2 (EBNA2), operating across different disease loci are linked to a higher risk of autoimmune diseases other than MS, including systemic lupus erythematosus, rheumatoid arthritis, and Sjö gren's syndrome [13][14][15][16].…”

Section: Multiple Sclerosis and Ebv: Evolution Of The Theorymentioning

confidence: 99%

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

Bar‐Or

Pender

Khanna

et al. 2020

Trends in Molecular Medicine

205

149

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New treatments for multiple sclerosis (MS) focused on B cells have created an atmosphere of excitement in the MS community. B cells are now known to play a major role in disease, demonstrated by the highly impactful effect of a B cell-depleting antibody on controlling MS. The idea that a virus may play a role in the development of MS has a long history and is supported mostly by studies demonstrating a link between B cell-tropic Epstein-Barr virus (EBV) and disease onset. Efforts to develop antiviral strategies for treating MS are underway. Although gaps remain in our understanding of the etiology of MS, the role, if any, of viruses in propagating pathogenic immune responses deserves attention. HighlightsClinical studies show that depletion of B cells reduces disease burden in both relapsing-remitting and progressive multiple sclerosis (MS) patients.

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Section: Multiple Sclerosis and Ebv: Evolution Of The Theorymentioning

confidence: 99%

Epstein–Barr Virus in Multiple Sclerosis: Theory and Emerging Immunotherapies

Bar‐Or

Pender

Khanna

et al. 2020

Trends in Molecular Medicine

205

149

View full text Add to dashboard Cite

show abstract

“…Furthermore, there were no MS patients who reported IM in their past history. Although IM is an established risk factor for MS in European ancestries (Sheik-Ali, 2017), the lower prevalence of IM in Japanese compared with Caucasians (Takeuchi et al, 2006) may partly explain this observation. Future large-scale prospective studies are warranted to clarify the causality of the environmental factors associated with MS in Japanese.…”

Section: Discussionmentioning

confidence: 98%

Environmental risk factors for multiple sclerosis in Japanese people

Sakoda

Matsushita

Nakamura

et al. 2020

Multiple Sclerosis and Related Disorders

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Background: The prevalence of multiple sclerosis (MS) has been increasing worldwide in recent years, especially among females. The same increasing trends are even observed in East Asian countries, where the prevalence of MS is relatively low compared with Northern European ancestries. Whether the environmental risk factors for MS are shared between Asian and North European ancestries, and the types of environmental factors that contribute to the low and recent increase in MS prevalence in Asian countries remain unknown. This study provides the first comprehensive survey of environmental risks for MS in East Asia.

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“…K E Y W O R D S antibiotics, logistic regression, multiple sclerosis, population-based incident case-control, random digit dialing, viral infections | 309 ABDOLLAHPOUR et AL.case-control study of children in Denmark (455 cases and 1801 controls), there was no association between the cumulative number of viral infections and the risk of MS. 11 Inconsistently, in Abbasi et al study, former infection with measles OR 1.60 (95% CI: 1.05-2.45) and mumps OR 1.85 (95% CI: 1.22-2.78) were both associated with MS. 12 Moreover, clinically observed chickenpox was shown to be a protective factor for MS onset OR 0.58 (95% CI: 0.36, 0.92) in a French population. 13 Nonetheless, there is consistent evidence demonstrating the underlying positive association between infectious mononucleosis (IM) and the risk of MS. [14][15][16] However, the potential mechanism of this acknowledged association along with the possible interactions with demographic and environmental factors including age, sex, socioeconomic status, smoking, and vitamin D sufficiency/sun exposure in populations with different genetic back-…”

mentioning

confidence: 99%