Infectious Mononucleosis, Hemolysis, and Megaloblastic Arrest

Mengel, Charles E.

doi:10.1001/archinte.1964.03860090067004

Cited by 6 publications

(3 citation statements)

References 17 publications

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“…Further, if at the time of the hyperplastic stimulus the patient's reserves of one or more haemopoietic principles (the term is used in its broadest interpretation) are marginal, then highly unusual cytological features may follow due to the rapid and total depletion of these reserves. This suggestion was offered by Mengel et al (1964) to explain the findings in their case, and could also explain the bizarre findings in our case 1 although no depletion was found as far as our incomplete investigations went.…”

Section: Sternal Bone Marrow Findingssupporting

confidence: 63%

“…However, they noted also that the M/E ratio was 15/10 which could indicate at least marked erythroid hyperplasia, and would not exclude simultaneous myeloid hyperplasia. 7 MEGALOBLASTIC MARROW ARREST This was recently reported by Mengel, Wallace, and McDaniel (1964) who considered this finding to be due to temporary 'relative' folate deficiency.…”

Section: Erythroid and Megakaryocytic Hyperplasiamentioning

confidence: 88%

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Bone marrow in nine cases of clinical glandular fever and a review of the literature

Boyd¹,

Reid²

1968

J Clin Pathol

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A review of the literature and the findings of a bone marrow examination in nine patients with glandular fever are reported. All marrows showed marked generalized hyperplasia of erythroid, myeloid, megakaryocytic, and reticulum cell elements with a greater or less `shift to the left' in the first three cell groups. The hyperplasia was maximal in two cases. Another case (the index case which was responsible for initiating this study) showed extremely bizarre cytological features of all four elements, and from many fields in the marrow smears it would have been possible to make a diagnosis of malignant transformation of any of the four marrow components. All these changes had returned to near normality on repeat marrow examination 15 months later.

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Section: Sternal Bone Marrow Findingssupporting

confidence: 63%

Section: Erythroid and Megakaryocytic Hyperplasiamentioning

confidence: 88%

Bone marrow in nine cases of clinical glandular fever and a review of the literature

Boyd¹,

Reid²

1968

J Clin Pathol

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“…Autoimmune haemolytic anaemia as a complication of EBV infection was first described by Dameshek in 1943 2 . Although a number of cases have been reported 2–10 . clinically apparent haemolysis is uncommon, occurring in less than 2% of patients 11 .…”

Section: Discussionmentioning

confidence: 99%

Haemolytic Anaemia Complicating Epstein‐barr Virus Infection

Whitelaw

Brook

Kennedy

et al. 1995

Int J Clinical Practice

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SUMMARY Hepatitis is a well‐recognised complication of Epstein‐Barr virus (EBV) infection that usually resolves spontaneously. Jaundice occasionally results from the unusual complication of autoimmune haemolytic anaemia rather than hepatitis. Two adult patients are described with infectious mononucleosis‐related hepatitis who also developed significant haemolysis, a situation that could have led to diagnostic delay and a deleterious outcome. Haemolysis should be considered in all patients who become jaundiced after infectious mononucleosis. The management of this potentially fatal complication is discussed.

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Atypical Presentations

Sumaya¹

1989

Clinical Topics in Infectious Disease

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Infectious Mononucleosis, Hemolysis, and Megaloblastic Arrest

Cited by 6 publications

References 17 publications

Bone marrow in nine cases of clinical glandular fever and a review of the literature

Bone marrow in nine cases of clinical glandular fever and a review of the literature

Haemolytic Anaemia Complicating Epstein‐barr Virus Infection

Atypical Presentations

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