Infectious Mononucleosis With Neurologic Complications

Dolgopol, Vera B.

doi:10.1001/archinte.1949.00220310062006

Cited by 54 publications

(8 citation statements)

References 20 publications

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“…This picture of a florid encephalitis differs considerably from findings hitherto reported. Although the clinical diagnosis of encephalitis is frequently made (Epstein and Dameshek, 1931;Johansen, 1931; and many others, reviewed by Gautier-Smith, 1965) most of the post-mortem lindings suggested a non-inflammatory nature of the process (Thomsen and Vimtrup, 1939;Peters et al, 1947;Dolgopol and Husson, 1949;Bergin, 1960). Some of the abnormalities described are indistinguishable from post-mortem artefacts, others represent terminal phenomena, others still may be ascribed to encephalopathies, anoxic, post-convulsive, hyperpyrexial or unexplained, sometimes loosely termed " allergic ".…”

Section: Discussxonmentioning

confidence: 99%

Acute encephalitis in infectious mononucleosis

Sworn

Urich

1970

The Journal of Pathology

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Section: Discussxonmentioning

confidence: 99%

Acute encephalitis in infectious mononucleosis

Sworn

Urich

1970

The Journal of Pathology

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“…Custer and Smith (1948) made extensive pathological observations on the basis of nine necropsies, two of which had come about from acute polyneuritis. Dolgopol and Husson (1949) reported a fatal case, designated haemorrhagic encephalomyopathy, and found 16 reported deaths of which seven were due to nervous system involvement. Silversides and Richardson (1950) listed eight from this cause.…”

Section: Discussionmentioning

confidence: 99%

“…Librach (1952) published a case of encephalitis and later (1954) another. Other individual reports of encephalitis have come from Landes et al (1941), Zohman andSilverman (1942), Geliebter (1946), Slade (1946), Schneider and Michelson (1947), Dolgopol and Husson (1949), McNeel (1951), and Hubler, Bailey, Campbell, and Mathieson (1951. Nineteen of the 59 cases collected by Silversides and Richardson (1950), four of the 34 reported by Bernstein and Wolff (1950), and 15 of the 71 reviewed by Leibowitz (1953) were encephalitic.…”

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confidence: 99%

Fatal Encephalopathy in Glandular Fever

Bergin¹

1960

Journal of Neurology, Neurosurgery & Psychiatry

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“…Lymphomonozytoide Zellen können durch die leukozytose ganz in den Hintergrund gedrängt werden und der Wahrnehmung vor allem dann entgehen, wenn der Untersucher keine klinischen Hinweise auf eine infektiöse Mononukleose erhalten hat. Auch in der Literatur werden solche Beobachtungen mitgeteilt: Offensichtlich hängt der Nachweis, zumindest aber die relative Quantität der fUr Epstein-Barr-Virusinfektion charakteristischen, abnormen mononukleären Zellen ganz wesentlich vom Zeitpunkt der Blutentnahme innerhalb des Krankheitsverlaufes ab (10). So sank der Anteil mononukleärer Zellen bei dem von (39,46).…”

Section: Temporo-basalenunclassified

Polyradikulomeningoenzephalitis durch Epstein-Barr-Virusinfektion - Darstellung eines Falles mit tödlichem Ausgang

Ringelstein¹,

Sobczak

Pfeifer

et al. 1984

Fortschr Neurol Psychiatr

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A 21 years old high school student, who, since early childhood, suffered from complete spinal paraplegia of unknown cause at D 10, suddenly, after a three week period with influenca -like prodromal symptoms, presented with acute polyradiculomeningoencephalitis . Positive reactions following Paul-Bunnell- Davidsohn -test and tests for specific antivirus IgG as well as specific IgM revealed acute Epstein-Barr-Virus infection, although no glandular signs could be found. The clinical findings consisted of peripheral sensory-motor tetraparesis, ataxia, nystagmus and disturbances of the caudal cranial nerves. Initially, the diagnosis of Fisher's syndrome was made. The orbicularis oculi reflex, however, indicated a circumscribed brainstem lesion in the medial reticular formation. This finding lead to the additional clinical diagnosis of encephalitis. Shortly after admission, a heart-arrest occurred, and, after successful reanimation, the patient presented with a "locked-in syndrome". On the 12th day after admission, he succumbed during a sudden drop of blood-pressure. Necropsy revealed septic shock as the cause of death, due to perforation of a duodenal ulcer. In the lower thoracic spinal cord a neurocytoma was found, which once lead to the paraplegia. Additionally, moderate inflammatory infiltrations were found in the basal leptomeninges, in the walls of several subcortical vessels and in the hypoglossal nerve. The infiltrations, at some sites, contained a large number of atypical lymphoid cells in the inflammatory meningeal exsudate . Microglial proliferation with satellitosis was found in the inferior olives, thus confirming the clinical diagnosis of polyradiculomeningoencephalitis . This case report should emphasize special features of EBV-infection with neurological complications: (1) in inflammatory diseases of the peripheral and central nervous system, infectious mononucleosis should always be drawn into the diagnostic considerations, even if heterophil antibodies and glandular symptoms are lacking. (2) In Guillain-Barré-syndrome, a transient external heart stimulator should be administered, in order to prevent heart arrest from acute autonomic neuropathy.

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Infectious Mononucleosis With Neurologic Complications

Cited by 54 publications

References 20 publications

Acute encephalitis in infectious mononucleosis

Acute encephalitis in infectious mononucleosis

Fatal Encephalopathy in Glandular Fever

Polyradikulomeningoenzephalitis durch Epstein-Barr-Virusinfektion - Darstellung eines Falles mit tödlichem Ausgang

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