Infectious Myelitis

Miyoshi, Isabeli Camila; Toledo, André Henrique Nogueira de; Pereira, Fernanda Veloso; Villarinho, Luciano de Lima; Dalaqua, Mariana; Duarte, Juliana de Ávila; Reis, Fabiano

doi:10.1053/j.sult.2023.03.015

Cited by 8 publications

(8 citation statements)

References 51 publications

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“…Both cases offer intriguing insights into the possible neurological complications of the virus. For patient IAL-430/2017, their case report details the incidence of viral myelitis, a condition wherein the spinal cord becomes inflamed due to viral infections [ 34 ]. Historically, various viruses, including viruses from the Picornaviridae family, herpesviruses, and flaviviruses, have been identified as etiological agents for viral myelitis [ 34 , 35 , 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…For patient IAL-430/2017, their case report details the incidence of viral myelitis, a condition wherein the spinal cord becomes inflamed due to viral infections [ 34 ]. Historically, various viruses, including viruses from the Picornaviridae family, herpesviruses, and flaviviruses, have been identified as etiological agents for viral myelitis [ 34 , 35 , 36 ]. Patient IAL-461/2019 presents a more complex clinical scenario, with the onset of encephalitis occurring post-liver transplant.…”

Section: Discussionmentioning

confidence: 99%

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Pegivirus Detection in Cerebrospinal Fluid from Patients with Central Nervous System Infections of Unknown Etiology in Brazil by Viral Metagenomics

Carmona,

Cilli,

da Costa

et al. 2023

Microorganisms

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Metagenomic next-generation sequencing (mNGS) methodology serves as an excellent supplement in cases where diagnosis is challenging to establish through conventional laboratory tests, and its usage is increasingly prevalent. Examining the causes of infectious diseases in the central nervous system (CNS) is vital for understanding their spread, managing outbreaks, and effective patient care. In a study conducted in the state of São Paulo, Brazil, cerebrospinal fluid (CSF) samples from 500 patients with CNS diseases of indeterminate etiology, collected between 2017 and 2021, were analyzed. Employing a mNGS approach, we obtained the complete coding sequence of Pegivirus hominis (HPgV) genotype 2 in a sample from a patient with encephalitis (named IAL-425/BRA/SP/2019); no other pathogen was detected. Subsequently, to determine the extent of this virus’s presence, both polymerase chain reaction (PCR) and/or real-time PCR assays were utilized on the entire collection. The presence of the virus was identified in 4.0% of the samples analyzed. This research constitutes the first report of HPgV detection in CSF samples in South America. Analysis of the IAL-425 genome (9107 nt) revealed a 90% nucleotide identity with HPgV strains from various countries. Evolutionary analyses suggest that HPgV is both endemic and extensively distributed. The direct involvement of HPgV in CNS infections in these patients remains uncertain.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Pegivirus Detection in Cerebrospinal Fluid from Patients with Central Nervous System Infections of Unknown Etiology in Brazil by Viral Metagenomics

Carmona,

Cilli,

da Costa

et al. 2023

Microorganisms

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“…Both TM and LETM are rare presentations of neurotuberculosis, but TM is more related to this diagnosis than LETM, especially when associated to cerebral or systemic disseminated disease. On the other hand, LETM is more related to autoimmune diseases, such as neuromyelitis Optica spectrum disorders [ 76 ].…”

Section: Spinal Tuberculosis ( Fig 9 A-9d)mentioning

confidence: 99%

“…Spinal intramedullary tuberculoma occurs in 2: 100,000 cases of tuberculosis and in 2 % of all cases of neurotuberculosis, appearing as a thickened spinal cord with oval lesions. The lesions demonstrate low signal in T1 images, with a “target sign” on T2 images and an irregular peripheric enhancement after contrast administration [ 76 ].…”

Section: Spinal Tuberculosis ( Fig 9 A-9d)mentioning

confidence: 99%

Magnetic resonance imaging findings in central nervous system tuberculosis: A pictorial review

Dahal,

Parajuli

2024

Heliyon

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“…Diffusion-weighted images are currently not used for spinal imaging; however, they may be an essential diagnostic tool for spinal infections 3 , particularly in patients with contraindications for gadolinium contrast medium injection.…”

mentioning

confidence: 99%

Spondylodiscitis caused by the Burkholderia cepacia complex

Candido,

Borella,

Ramos

et al. 2024

Rev. Soc. Bras. Med. Trop.

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Infectious Myelitis

Cited by 8 publications

References 51 publications

Pegivirus Detection in Cerebrospinal Fluid from Patients with Central Nervous System Infections of Unknown Etiology in Brazil by Viral Metagenomics

Pegivirus Detection in Cerebrospinal Fluid from Patients with Central Nervous System Infections of Unknown Etiology in Brazil by Viral Metagenomics

Magnetic resonance imaging findings in central nervous system tuberculosis: A pictorial review

Spondylodiscitis caused by the Burkholderia cepacia complex

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