Infectious Vasculopathy of Intracranial Large- and Medium-Sized Vessels in Neurological Intensive Care Unit: A Clinico-Radiological Study

Katchanov, Juri; Siebert, Eberhard; Klingebiel, Randolf; Endres, Matthias

doi:10.1007/s12028-010-9335-4

Cited by 38 publications

(20 citation statements)

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“…Occlusion of the MCA with development of moyamoya collaterals has been reported in children (20). Vessel wall thickening and contrast-enhanced vessel walls on imaging have been seen in VZV vasculopathy (21). In 5/6 patients with virologically-verified VZV vasculopathy confirmed by the presence of anti-VZV IgG antibody in CSF, vessel wall enhancement on highresolution MRI resolved and arterial stenosis improved or stabilized after treatment with intravenous acyclovir (22).…”

Section: Clinical Laboratory and Imaging Features Of Vzv Vasculopathymentioning

confidence: 99%

Varicella Zoster Virus: A Common Cause of Stroke in Children and Adults

Amlie‐Lefond

Gilden

2016

Journal of Stroke and Cerebrovascular Diseases

104

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Background-Varicella zoster virus (VZV) is a neurotropic exclusively human herpesvirus. Primary infection causes varicella (chickenpox), after which virus become latent in ganglionic neurons along the entire neuraxis. As cell-mediated immunity to VZV declines with advancing age and immunosuppression, VZV reactivates to produce zoster (shingles). One of the most serious complications of zoster is VZV vasculopathy.

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Section: Clinical Laboratory and Imaging Features Of Vzv Vasculopathymentioning

confidence: 99%

Varicella Zoster Virus: A Common Cause of Stroke in Children and Adults

Amlie‐Lefond

Gilden

2016

Journal of Stroke and Cerebrovascular Diseases

104

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“…While treatment reduces further stroke [4], the course of resolution of vessel inflammation and stenosis is unknown. Recent studies using contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) showed that vessel wall thickening and enhancement correlate with vessel wall inflammation in central nervous system vasculitis [5], including VZV vasculopathy [6,7], however, data on follow up imaging after treatment has not been previously published. Knowledge of the extent and evolution of vessel wall enhancement, which likely reflects inflammation, may help to guide treatment.…”

Section: Introductionmentioning

confidence: 99%

High-resolution MRI vessel wall imaging in varicella zoster virus vasculopathy

Cheng-Ching

Jones

Hui

et al. 2015

Journal of the Neurological Sciences

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Contrast-enhanced vessel wall imaging high-resolution MRI (HRMR) has revealed vessel wall thickening and enhancement in multiple intracranial vasculopathies, including varicella zoster virus (VZV) vasculopathy. We retrospectively reviewed a database of patients with virologically-verified VZV vasculopathy, who underwent initial and follow-up HRMR between April 2011 and May 2014. Six patients were identified. Baseline demographic and clinical characteristics were collected, including stroke risk factors, history of VZV-related disorders, neurological presentation, course and antiviral treatment. Initial HRMR in patients with VZV vasculopathy demonstrated various patterns of stenosis, vessel wall thickening and enhancement, predominantly in terminal internal carotid artery segments and the M1 segment of the middle cerebral arteries. Follow-up HRMR showed improvement of stenosis, with reduced vessel wall thickening and enhancement at multiple times after treatment. HRMR has the potential to assist in diagnosis and treatment of VZV vasculopathy.

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“…In a recent study on infectious CNS vasculitis, magnetic resonance angiography was shown to detect vasculopathic signs in all 8 patients. 12 In our case, TOF angiography with a 3 T scanner was sufficient to visualize alterations in large to medium-sized arteries. Contrast-enhanced T1-weighted images may be even more sensitive by detection of vessel wall enhancement, particularly if medium to small vessels are affected.…”

Section: Oystersmentioning

confidence: 60%