Infective Dermatitis in an Adult Patient With HTLV-1

Abstract

Abstract:Infective dermatitis is a chronic exudative eczematous eruption presenting in human T-lymphotropic virus type 1 (HTLV-1)–infected people. It presents with relapsing erythematous, scaly, and crusted lesions affecting simultaneously the scalp, external ear, retroauricular area, eyelid, paranasal skin, neck axilla, and groin. Superimposed Staphylococcus and Streptococcus infection are common. It mainly affects children and exceptionally adults, and there are only a few published cases. The authors present the first reported case in Paraguay of an adult patient who had symptoms of human T-lymphotropic virus type 1–associated progressive tropical spastic paraparesis, and 6 years after the onset of the neurological symptoms, the patient developed infective dermatitis lesions on the skin, with frequent exacerbations since then.

Decreased RORC expression and downstream signaling in HTLV‐1‐associated adult T‐cell lymphoma/leukemia uncovers an antiproliferative IL17 link: A potential target for immunotherapy?

“…ATL pathogenesis develops over decades as is seen by patients presenting at least 20 years after HTLV‐1 infection; yet not all infected patients develop ATL. Observational studies suggest that ATL, at least in the Caribbean and Brazil, can be triggered by the pediatric cutaneous manifestation known as Infectious Dermatitis . ID is a chronic, eczematous condition with scaly, crusted lesions often superimposed by Staphylococcus aureus or Streptococcus pyogenes infections .…”

“…Observational studies suggest that ATL, at least in the Caribbean and Brazil, can be triggered by the pediatric cutaneous manifestation known as Infectious Dermatitis. [39][40][41][42] ID is a chronic, eczematous condition with scaly, crusted lesions often superimposed by Staphylococcus aureus or Streptococcus pyogenes infections. 39,40 Defects in the Th17 axis increase vulnerability to S. aureus and Candida albicans infections, whereas in vivo S. aureus primed memory Th17 cells inhibited IL-17 production and increased IL-10 production.…”

“…[39][40][41][42] ID is a chronic, eczematous condition with scaly, crusted lesions often superimposed by Staphylococcus aureus or Streptococcus pyogenes infections. 39,40 Defects in the Th17 axis increase vulnerability to S. aureus and Candida albicans infections, whereas in vivo S. aureus primed memory Th17 cells inhibited IL-17 production and increased IL-10 production. 41,43 Of interest, two recent papers have demonstrated a role for IL-10 as an unexpected proliferative trigger of infected CD4+ T-cell clones and, possibly, leukemogenesis.…”

Decreased RORC expression and downstream signaling in HTLV-1-associated Adult T-cell Lymphoma/Leukemia uncovers an antiproliferative IL17 link: a potential target for immunotherapy?

“…ATL pathogenesis develops over decades as is seen by patients presenting at least 20 years after HTLV-1 infection; yet not all infected patients develop ATL. Observational studies suggest that ATL, at least in the Caribbean and Brazil, can be triggered by the pediatric cutaneous manifestation known as Infectious Dermatitis [45][46][47][48] . ID is a chronic, eczematous condition with scaly, crusted lesions often superimposed by Staphylococcus aureus or Streptococcus pyogenes infections 45,46 .…”

“…Observational studies suggest that ATL, at least in the Caribbean and Brazil, can be triggered by the pediatric cutaneous manifestation known as Infectious Dermatitis [45][46][47][48] . ID is a chronic, eczematous condition with scaly, crusted lesions often superimposed by Staphylococcus aureus or Streptococcus pyogenes infections 45,46 . Defects in the Th17 axis increase vulnerability to S. aureus and Candida albicans infections, whereas in vivo S. aureus primed memory Th17 cells inhibited IL-17 production and increased IL-10 production 47,49 .…”