Infective Endarteritis in Patent Ductus Arteriosus and Septic Pulmonary Embolism

Cruz-González, Ignacio; Martín-Herrero, Francisco; Sánchez, José López

doi:10.1016/s1885-5857(06)60780-9

Cited by 6 publications

(5 citation statements)

References 8 publications

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“…Associated cardiovascular defects were rarely reported in patients with endarteritis because of PDA. Only three patients were found in 24 publications (pulmonary stenosis, coarctation of the aorta, and rheumatic valve disease) (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22). It is worth noting that subvalvular aortic stenosis was present in three of the 17 patients in our study group.…”

Section: Discussionmentioning

confidence: 62%

Echocardiographic findings in patent ductus arteriosus-associated infective endarteritis

Saucedo-Orozco

Vargas-Barrón

Vázquez-Antona

et al. 2021

The Anatolian Journal of Cardiology

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Section: Discussionmentioning

confidence: 62%

Echocardiographic findings in patent ductus arteriosus-associated infective endarteritis

Saucedo-Orozco

Vargas-Barrón

Vázquez-Antona

et al. 2021

The Anatolian Journal of Cardiology

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“…Most case reports include patients with an isolated PDA, not associated with other types of CHD or previous cardiac surgery, except one case, where the PDA‐IE involves the pulmonary valve. As in the majority of case reports on PDA‐IE, the origin of the bacteremia was unclear in our patient. Whether the mild redness of the umbilicus before hospital admission was a skin infection and therefore responsible for bacterial entrance remains open.…”

Section: Discussionmentioning

confidence: 72%

“…According to our literature review (Table ), the typical presentation of a PDA‐IE is characterized by prolonged fever (for weeks or even months), sometimes associated to clinical signs of an hemodynamic relevant PDA (fatigue, heart failure, anorexia) or of complications of a PDA‐IE such as septic pulmonary or systemic embolisms. Most case reports include patients with an isolated PDA, not associated with other types of CHD or previous cardiac surgery, except one case, where the PDA‐IE involves the pulmonary valve.…”

Section: Discussionmentioning

confidence: 99%

“…The ductus arteriosus Botalli connects the descending aortic arch with the roof of the main and left pulmonary artery and serves as an obligatory right‐to‐left shunt during fetal life. Since first successful surgical ligation of a patent ductus arteriosus (PDA) in 1938 and the establishment of medical and interventional techniques for PDA closure, infective endarteritis in patients with a PDA is a rare or even disappearing clinical entity in developed countries and only described in cases reports and one retrospective study with vegetations related to hemodynamic relevant or less relevant PDA found either in postmortem studies or echocardiographic evaluations. However, in developing countries a PDA remains a predisposing risk factor for IE …”

Section: Introductionmentioning

confidence: 99%

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Ductus arteriosus‐associated infective endarteritis: Lessons from the past, future perspective

Callegari

Burkhardt

Relly

et al. 2019

Congenital Heart Disease

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Background Since routine clinical use of antibiotics as well as surgical and catheter‐based closure of a patent arterial duct (PDA), PDA‐associated infective endarteritis (PDA‐IE) is rare but can still occur when the ductus is still open or as it closes. Thus, clinicians should maintain a high index of concern for patients with unexplained fever. Methods We report on a PDA‐IE in a young infant shortly after potentially delayed obliteration of a PDA. We discuss this case report by reviewing the literature in regard to the pathogenesis (infection primary or secondary to PDA thrombus formation), clinical (new heart murmur) and diagnostic findings (transthoracic echocardiography, total body MRI, laboratory findings), and clinical outcome during mid‐term follow‐up after successful antibiotic treatment. Results A 7‐week‐old term infant with Staphylococcus aureus sepsis and a new heart murmur was diagnosed with PDA‐IE by transthoracic echocardiography at the pulmonary artery end of an obliterated PDA. Broad diagnostic workup excluded other reasons for sepsis. After 4 weeks of antibiotic treatment the vegetation reduced in size and the infant recovered completely. A review of all cases of PDA‐IE (in pediatric and adult patients) previously published was performed. Conclusion Nowadays, a PDA‐IE is an extremely rare, but still life‐threating condition that may even affect patients with a nonpatent ductus arteriosus shortly after its obliteration and should be considered as infective complication in preterms, neonates, and small infants. Therefore, in septic neonates with bacteremia, transthoracic echocardiography may be integrated in the diagnostic workup, especially by fever without source and clinical signs of IE such as a new heart murmur.

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“…The administration of antibiotics has brought about a notable alteration in the frequency and prognosis of endarteritis among patients with PDA. However, it continues to be a potent complication even in cases where PDA is asymptomatic [ 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

Unveiling the Silent Ductus: A Classical Presentation of Patent Ductus Arteriosus in an Asymptomatic 23-Year-Old Male

Charpuria,

Ganampet,

Kurian

et al. 2023

Cureus

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The patent ductus arteriosus (PDA) refers to the persistence of a connection between the descending aorta distal to the left subclavian artery and the pulmonary trunk beyond fetal life. Adult congenital heart disease is a rare condition, with asymptomatic cases being particularly uncommon. The following report presents the case of a young adult male, aged 23, who was discovered to possess a patent ductus arteriosus in an incidental manner. The patient presented with an acute chest complaint and was found to be asymptomatic upon examination at the hospital. Based on the preliminary medical information provided, a tentative diagnosis of a ventricular septal defect was established. However, a comprehensive echocardiographic examination revealed the presence of a patent ductus arteriosus (PDA).

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Infective Endarteritis in Patent Ductus Arteriosus and Septic Pulmonary Embolism

Cited by 6 publications

References 8 publications

Echocardiographic findings in patent ductus arteriosus-associated infective endarteritis

Echocardiographic findings in patent ductus arteriosus-associated infective endarteritis

Ductus arteriosus‐associated infective endarteritis: Lessons from the past, future perspective

Unveiling the Silent Ductus: A Classical Presentation of Patent Ductus Arteriosus in an Asymptomatic 23-Year-Old Male

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