Infective endocarditis by <i>Acinetobacter</i> species: a systematic review

Ιωάννου, Πέτρος; Mavrikaki, Vasiliki; Kofteridis, Diamantis P.

doi:10.1080/1120009x.2020.1812804

Cited by 23 publications

(35 citation statements)

References 58 publications

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Section: Discussionmentioning

confidence: 87%

“…The mean age at diagnosis of patients with Yersinia IE was 67 years, which is slightly higher than the age at diagnosis of IE by non-HACEK Gram-negative bacilli in the literature, which is in the range of 40 to 63 years [ 6 , 7 , 8 , 9 , 34 ]. A male predominance among patients with IE by Yersinia species was noted, as in other cases of IE caused by non-HACEK Gram-negative bacilli [ 6 , 7 , 8 , 9 , 34 ]. A prosthetic valve was present in 17% of patients with IE by Yersinia , which is lower than the rate mentioned in other studies of IE by non-HACEK Gram-negative bacilli, which is between 25% and 59% [ 6 , 7 , 8 , 9 , 34 ].…”

Section: Discussionmentioning

confidence: 87%

“…Regarding patients’ clinical signs, fever was the most common symptom, occurring in 92% of patients, while 70% of patients were septic. In studies with IE caused by non-HACEK Gram-negative bacilli, presence of fever was noted in 91% to 100% [ 6 , 7 , 8 , 9 ] and sepsis in 79% to 85% of patients [ 8 , 9 ]. Notably, 15% of patients with IE caused by Yersinia developed heart failure, a proportion similar to that in cases of non-HACEK Gram-negative IE which ranged from 8% to 37% [ 6 , 7 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…IE by non-HACEK Gram-negative bacteria is associated with a notable risk of mortality and morbidity, such as development of intracardiac abscess and vascular complications such as peripheral embolism or stroke [ 6 , 7 ]. The most commonly identified Gram-negative microorganisms associated with IE by Gram-negative bacteria in the literature are Escherichia coli , Pseudomonas aeruginosa and Klebsiella species; however, IE caused by other non-HACEK Gram-negative bacteria has been described in the literature [ 6 , 8 , 9 ]. This disease often requires a combination of antimicrobials along with surgery in order to achieve a cure [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…This disease often requires a combination of antimicrobials along with surgery in order to achieve a cure [ 6 ]. However, depending on the species, there may be specific problems associated with its treatment, such as antimicrobial resistance [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

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Infective Endocarditis by Yersinia Species: A Systematic Review

et al. 2021

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Yersinia spp. are non-spore-forming Gram-negative bacilli. They comprise only three species known to cause disease in humans, namely Y. pestis, Y. enterocolitica and Y. pseudotuberculosis. Since infective endocarditis (IE) is rarely caused by Yersinia, the management of these infections can be problematic due to the lack of experience. The purpose of this study was to systematically review all published cases of IE by Yersinia species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 1 November 2020) for studies providing epidemiological, clinical and microbiological information as well as data on treatment and outcomes of IE caused by Yersinia species was performed. A total of 12 studies, containing data of 12 patients, were included. A prosthetic valve was present in 17% of patients. The mitral valve was the most commonly infected site, followed by the aortic valve. Fever, sepsis and embolic phenomena were common clinical signs, followed by heart failure. Aminoglycosides, cephalosporins and quinolones were the most commonly used antimicrobials. Clinical cure was noted in 83%, while overall mortality was 17%. This systematic review describes IE by Yersinia and provides information on patients’ epidemiology, clinical signs and the related therapeutic strategies and outcomes.

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