Infective Endocarditis Complicated by Intracerebral Hemorrhage due to Lactococcus lactis subsp. cremoris

Lin, Kung‐Hung; Sy, Cheng Len; Chen, C.-S.; Lee, C.-H.; Lin, Yi Tsung; Li, J.-Y.

doi:10.1007/s15010-010-9219-3

Cited by 23 publications

(15 citation statements)

References 16 publications

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“…However, the pathway of infection was unidentified or not mentioned in all cases of IE hitherto reported [7][8][9]. In our case it was also unidentified.…”

Section: ．．．．Discussionmentioning

confidence: 51%

“…Lactococcus lactis is a member of the normal flora of the oropharyngeal, intestinal and vaginal cavities in human [17,18], and it is known that this agent sometimes shows pathogenicity in compromised host or in previously damaged tissue [17]. Some cases of Lactococcal infection in organs or tissues other than heart were reported previously [18][19][20][21][22][23] and a few cases of adult IE due to Lactococcus lactis subspecies were also reported [7][8][9]. However, there have not been described infantile cases of Lactococcal infection, and this is the first report of infantile fatal Lactococcal endocarditis according to our knowledge.…”

Section: ．．．．Discussionmentioning

confidence: 99%

“…From the aspect of etiologic agent, Lactococcal IE is very rare and only few adult cases were reported so far. [7][8][9], while most frequent one is Staphylococcus species. [1,2,[4][5][6][10][11][12].…”

Section: Introductionmentioning

confidence: 98%

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Sudden infant death due to Lactococcal infective endocarditis

et al. 2016

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“…However, the pathway of infection was unidentified or not mentioned in all cases of IE hitherto reported [7][8][9]. In our case it was also unidentified.…”

Section: ．．．．Discussionmentioning

confidence: 51%

Section: ．．．．Discussionmentioning

confidence: 99%

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Sudden infant death due to Lactococcal infective endocarditis

et al. 2016

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“…New human case reports related to infections caused by Lactococcus lactis have been published recently, including a liver abscess and empyema in an imunocompetent adult (Kim et al, 2010) and a bacteremia in an infant suffering from necrotizing enterocolitis and receiving total parentheral nutrition via silicone catether (Glickman et al, 2010) and an endocarditis in a middle aged man complicated by intracerebral haemorrhage and leading to the death of the patient (Lin et al, 2010). In all these cases the causative microorganism was typed as Lactococcus lactis ssp.…”

Section: Lactococcus Speciesmentioning

confidence: 99%

Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2011 update)

2011

EFSA Journal

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EFSA is requested to assess the safety of a broad range of biological agents (including microorganisms and viruses) in the context of notifications for market authorisation as sources of food and feed additives, enzymes and plant protection products. The qualified presumption of safety (QPS) assessment was developed by EFSA for its own use to provide a generic risk assessment approach applicable across EFSA's scientific Panels, for biological agents notified for intentional use in the whole food chain. The safety of unambiguously defined biological agents at the highest taxonomic unit that is appropriate for the purpose for which an application is intended and the completeness of the body of knowledge are assessed. Identified safety concerns for a taxonomic unit are where sensible reflected as ‘qualifications’ when a recommendation for the QPS list is given. The list of QPS recommended biological agents is reviewed and updated annually. Therefore, the only valid list is the one in the most recent scientific opinion. The 2011 update reviews microorganisms previously assessed including bacteria, yeasts, filamentous fungi and viruses used for plant protection purposes and confirms the previous recommendations. The anamorph yeast form Phaffia rhodozyma of Xanthophyllomyces dendrorhous was included on the QPS list and to the qualification for yeasts ‘absence of resistance to antimycotics used for medical treatment of yeast infections’, the sentence was added that ‘in the case of Saccharomyces cerevisiae this qualification applies for yeast strains able to grow above 37 °C’. The body of knowledge of filamentous fungi and enterococci was updated and their ineligibility for the QPS list confirmed.

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“…The route of L. lactis infection is not well understood (6,9). Bacterial translocation from the gut is a common source of bacteremia in patients with short bowel syndrome (10).…”

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confidence: 99%

<i>Lactococcus lactis</i> Catherter-Related Bloodstream Infection in an Infant: Case Report

et al. 2015

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SUMMARY: Lactococcus lactis is a gram-positive coccus that is nonpathogenic in humans. Herein, we present the case of a 1-year-old boy with Down syndrome and Hirschprung's disease (HD) who developed a catheter-related bloodstream infection with L. lactis after gastrointestinal surgery. The patient had been hospitalized in the pediatric surgery unit from birth because of HD, and had undergone the Duhamel-Martin procedure which caused recurrent diarrhea episodes and feeding intolerance. On the infant's 430th day of life, he had an episode of gastroenteritis and feeding intolerance. Because of clinical suspiction of sepsis, blood cultures were taken both from the central venous catheter and peripheral vein, and evidence of a growing microorganism was detected in 2 different central venous catheter blood cultures taken 2 days apart. The colonies were then identified by both the Vitek 2 and Vitek MS systems (bioM áerieux, Marseille, France) as L. lactis spp. lactis. The central venous catheter could not be removed because of the absence of a peripheral venous line, and the patient was subsequently successfully treated with vancomycin. Therefore, although Lactococcus species is generally thought to be nonpathogenic, it should still be kept in mind as a potential pathogen in infants.Catheter-related bloodstream infections (CR-BSIs) are an important source of morbidity and mortality worldwide. Lactococcus spp. are not recognized as important pathogens in humans, but the current literature provides evidence that they can cause infection, particularly in immunocompromised hosts (1). In this case study, we describe the second known case of CR-BSI caused by L. Lactis in an infant.A 1-year-old boy with Down syndrome (DS) had been hospitalized in the pediatric surgical care unit since birth. Because of vomiting, abdominal distension, and meconium ileus, rectal biopsy was performed 14 days after birth, revealing the absence of ganglion cells, he was thus diagnosed with Hirschprung's disease (HD). An ileostomy was performed on his 30th day of life. When the patient was 1-year old, the definitive Duhamel-Martin procedure was performed. The patient could not be discharged because he required total parenteral nutritional support from a central venous line via an 8-cm Triple-Lumen 5.5-Fr ARROW Catheter inserted into the femoral vein.On the patient's 430th day of life, he had an episode of gastroenteritis along with feeding intolerance, erosive diaper dermatitis, and a worsening clinical condition.He was also hypotensive and hypotonic subfebrile rise in temperature. No pathogenic microorganisms were found on stool. The laboratory results showed a white blood cell count of 14,800/mm 3 and C-reactive protein levels of 29.3 mg/L (0-5 mg/L). Furthermore, the infant's urinalysis was normal, his urine culture remained sterile and he had no signs of pneumonia.Because of the clinical suspiction of sepsis, blood cultures were taken both from the central venous catheter and peripheral vein. Fourteen hours later, the BacT/Alert device (bioM áe...

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Infective Endocarditis Complicated by Intracerebral Hemorrhage due to Lactococcus lactis subsp. cremoris

Cited by 23 publications

References 16 publications

Sudden infant death due to Lactococcal infective endocarditis

Sudden infant death due to Lactococcal infective endocarditis

Scientific Opinion on the maintenance of the list of QPS biological agents intentionally added to food and feed (2011 update)

<i>Lactococcus lactis</i> Catherter-Related Bloodstream Infection in an Infant: Case Report

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