Infective Endocarditis in Hypertrophic Cardiomyopathy

Casabé, Horacio; Fernández, Adrián; Renedo, María F.; Guevara, Eduardo; Favaloro, Liliana; Favaloro, Roberto

doi:10.7775/rac.v83.i4.5476

Cited by 3 publications

(5 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although there have been improvements in the treatment, prevention, and diagnosis of IE, most epidemiological studies indicate a rise in the incidence and mortality of IE. For example, from 2000 to 2019, the reported incidence of IE was about 15/100,000, and the mortality rate during hospitalization was as high as 20–30% ( 14 , 15 ). A study conducted in China ( 16 ) found that the annual incidence of IE ranges from 2/100,000 to 6/100,000.…”

Section: Discussionmentioning

confidence: 99%

Postoperative follow-up of 221 patients with infective endocarditis from Gaoligong mountain area of Yunnan in China: a retrospective, single-center, observational cohort study

Li,

Jia

et al. 2024

J Thorac Dis

View full text Add to dashboard Cite

Background Despite improvements in management, infective endocarditis (IE) is still associated with high mortality and morbidity. The outcome of patients with IE remains unclear in high-altitude areas of China. To characterize the epidemiological features and surgical outcomes, a retrospective analysis was conducted to 221 patients diagnosed with IE from a single center. In addition, to assess the prognosis of patients, a multivariate logistic regression model was performed to analyze the affecting risk factors. Methods A retrospective analysis was conducted on the clinical data of 221 patients with IE who underwent surgical treatment at the Department of Cardiac Surgery of Yan’an Hospital Affiliated to Kunming Medical University from January 2013 to December 2019. The analysis evaluated patient demographics, pathogenic bacterial composition, echocardiography results, and surgical treatment outcomes. After a 1-year follow-up period, the mortality rate was statistically analyzed. The patients were divided into two groups based on their survival status: those who survived and those who did not. Relevant factors were compared between the two groups, and a multivariate logistic regression model was used to analyze the risk factors that affect the prognosis of patients with IE. Results Out of the 221 patients diagnosed with IE, 164 were male and 57 were female, with an average age of 39.25±14.36 years. The most common underlying heart diseases were bicuspid aortic valve disease (24.9%), congenital heart disease (19.5%), rupture of aortic sinus aneurysm (5.0%) and rheumatic valvular disease (2.3%). The blood culture had a positive rate of 48.42% (107/221), with Streptococcus viridans (29.9%) and Streptococcus haematoides (13.1%) being the main specifically pathogenic bacteria identified. Transthoracic echocardiography produced positive results in 89.6% (198/221) of cases. The findings included vegetation formation (100%), valve perforation or tear (21.7%), and perivalvular abscess formation (5.6%). Out of the patients, 174 underwent elective surgery, 47 received emergency surgery, and 11 died within 1 year after surgery, resulting in a mortality rate of 5.0%. However, the death group had longer operation time, cardiopulmonary bypass (CPB) time and higher EuroSCORE II compared to the non-death group (P<0.05). Logistic regression analysis identified preoperative hematocrit decrease, prolonged operation time and CPB time, high New York Heart Association (NYHA) cardiac function grade, and liver diseases as risk factors for 1-year mortality in patients with IE (OR =1.003, 0.000, 1.006, 1.026, 1.624 and 4.746). Conclusions IE primarily affects young and middle-aged men with rheumatic heart valvular disease as the main underlying heart disease and Streptococcus viridans as the main pathogen. Surgical intervention significantly r...

show abstract

Section: Discussionmentioning

confidence: 99%

Postoperative follow-up of 221 patients with infective endocarditis from Gaoligong mountain area of Yunnan in China: a retrospective, single-center, observational cohort study

Li,

Jia

et al. 2024

J Thorac Dis

View full text Add to dashboard Cite

show abstract

“…The main manifestations include constitutional symptoms of several months of evolution including anorexia, weight loss, and fever, followed by heart failure or embolisms. Classic signs such as Roth's spots or Osler's nodules are infrequent [ 11 ]. The rate of complications and mortality is higher with these atypical microorganisms [ 8 , 12 ] compared to other types of endocarditis.…”

Section: Discussionmentioning

confidence: 99%

“…This higher frequency of complications is believed to be related to the subacute presentation or even special microbiological conditions of these microorganisms. For example, the production of heparinases by Bacteroides fragilis [ 11 ], or the greater affinity of Granulicatella adiacens for the valvular endothelium [ 8 ], the latter resulting in a similar mechanism as reported for Streptococcus mutans for increased collagen and laminin-binding [ 13 , 14 ]. The infection commonly involves the aortic and mitral valves, as reported in up to 64% of cases.…”

Section: Discussionmentioning

confidence: 99%

A Case Series and Literature Review of Subacute Infective Endocarditis: A Clinical Challenge

Callegari¹,

Cabrera²,

Mejia³

et al. 2023

Cureus

View full text Add to dashboard Cite

Endocarditis is a life-threatening, relatively rare disease caused by an infection of the endocardial epithelium of the heart. Its clinical presentation is highly variable, depending on whether it presents acutely, subacutely, or chronically. Also, the wide array of causal etiologies and pathogens makes its diagnosis and treatment complex and challenging. The main etiological agents are S taphylococci and S treptococci , while fastidious microorganisms are infrequent agents of this pathology. Advancements in the identification of microorganisms with novel molecular techniques have revealed new previously unidentified pathogens. Despite their low frequency, these fastidious pathogens are highly relevant, as they have been associated with a higher rate of complications and mortality. Therefore, it is necessary to be aware of the wide array of clinical presentations and important considerations for the management of patients with subacute endocarditis with atypical microorganisms. In this article, we present a case series involving three different clinical presentations of subacute endocarditis with fastidious microorganisms, which required extensive medical management and surgical valve repair with favorable and unfavorable outcomes. We also engage in a review of the literature on their microbiology, diagnosis, and treatment.

show abstract

“…[9,15,36]. По этому кардиохирургическому лечению ИЭ у больных ГКМП некоторые исследователи отдают предпочтение [9,10,36,47]. Преимуществами применения кардиохирургии являются возможность одновременной санации очага клапанной инфекции и коррекции гемодинамического дефекта, снижение частоты тромбоэмболий, СН, сепсиса и уменьшение смертности.…”

Section: лечение инфекционного эндокардита на фоне гипертрофической кардиомиопатииunclassified

“…Имплантация внутрисердечных устройств (кардиовертеров-дефибрилляторов) для лечения нарушений ритма у больных ГКМП является дополнительным фактором, увеличивающим риск ИЭ, ассоциированного с внутрисердечными устройствами [47]. По частоте эта разновидность ИЭ лишь незначительно уступает левостороннему ИЭ нативных клапанов у пациентов с ГКМП, встречается при обструктивной форме и в тактике лечения требует обязательного удаления имплантированного внутрисердечного устройства [47] в соответствии с согласительными документами [1]. Согласно данным крупного британского исследования [48], оценивающего риск развития ИЭ у лиц с предрасполагающими кардиальными факторами, риск ИЭ у пациентов с ГКМП был значительным.…”

Section: лечение инфекционного эндокардита на фоне гипертрофической кардиомиопатииunclassified

Infective Endocarditis in Patients with Hypertrophic Cardiomyopathy

Пономарева

Игнатенко

Тарадин

2021

Arhivʺ vnutrennej mediciny

View full text Add to dashboard Cite

A literature review is presented, reflecting the incidence, etiology, hemodynamics, localization, clinical manifestations, outcomes and treatment of infective endocarditis (IE) in patients with hypertrophic cardiomyopathy (HCM). Despite the relative rarity of IE in patients with HCM, the combination of these pathologies is characterized by mutual aggravation and poor prognosis. The addition of IE increases the risk of death in patients with obstructive HCM, deteriorating circulatory disorders, increasing the likelihood of uncontrolled sepsis and embolism. Conservative treatment of IE in patients with HCM does not differ from that without HCM. Interdisciplinary interaction is needed in the management of patients with IE against the background of HCM in determining the indications for cardiac surgery and choosing the optimal method. Antibacterial prophylaxis of IE before invasive medical manipulations in patients with HCM is not recommended by the current consensus documents, however, the decision for each patient should be made individually, with a mandatory assessment of the risk of IE, the severity of hemodynamic disorders and prognosis.

show abstract

Infective Endocarditis in Hypertrophic Cardiomyopathy

Cited by 3 publications

References 0 publications

Postoperative follow-up of 221 patients with infective endocarditis from Gaoligong mountain area of Yunnan in China: a retrospective, single-center, observational cohort study

Postoperative follow-up of 221 patients with infective endocarditis from Gaoligong mountain area of Yunnan in China: a retrospective, single-center, observational cohort study

A Case Series and Literature Review of Subacute Infective Endocarditis: A Clinical Challenge

Infective Endocarditis in Patients with Hypertrophic Cardiomyopathy

Contact Info

Product

Resources

About