Infective Endocarditis in Patients on Chronic Hemodialysis

Jiménez-Expósito, María Jesús; Kourany, Wissam M.; Montagna-Mella, Rodrigo; Mestres, Carlos A.; Miró, José M.; Clara, Liliana; Sánchez, Marisa López; Casabé, J. Horacio; Cortés, Claudia; Nacinovich, Francisco; Oses, P. Fernandez; Ronderos, Ricardo; Sucari, Adriana; Thierer, Jorge; Altclas, Javier; Kogan, Silvia; Spelman, Denis; Athan, Eugene; Harris, Owen; Kennedy, Karina; Tan, R.; Gordon, David L.; Papanicolas, Lito E.; Korman, Tony M.; Kotsanas, Despina; Dever, Robyn; Konecny, Pam; Lawrence, Richard; Rees, David; Feneley, Michael P.; Harkness, John; Jones, Phillip D.; Post, Jeffrey J.; Reinbott, Porl; Ryan, Suzanne M.; Gattringer, Rainer; Wiesbauer, Franz; Andrade, Adriana Ribas; Brito, Ana Cláudia Passos de; Guimarães, Armênio Costa; Grinberg, Max; Mansur, Alfredo José; Siciliano, Rinaldo Focaccia; Strabelli, Tânia Mara Varejão; Vieira, Marcelo Luiz Campos; Tranchesi, Regina Aparecida de Medeiros; Paiva, Marcelo Goulart; Fortes, Cláudio Querido; Ramos, Auristela de Oliveira; Weksler, Clara; Ferraiuoli, G.; Golebiovski, W.; Lamas, Cristiane da Cruz; Karlowsky, James A.; Keynan, Yoav; Morris, Andrew M.; Jones, Sandra Braun; García, Patricia; Cereceda, Mauricio; Fíca, Alberto; Mella, Rodrigo Montagna; Fernández, Ricardo; Franco, Liliana; González, Javier Mauricio; Jaramillo, Astrid Natalia; Baršić, Bruno; Bukovski, Suzana; Krajinović, Vladimir; Pangerčić, Ana; Rudež, Igor; Vincelj, Josip; Freiberger, Tomáš; Pol, Jiří; Žaloudíková, Barbora; Ashour, Zainab; Kholy, Amani El; Mishaal, Marwa; Osama, Dina; Rizk, Hussien; Aissa, Neijla; Alauzet, Corentine; Alla, François; Campagnac, CHU Catherine; Doco‐Lecompte, T.; Selton‐Suty, Christine; Casalta, Jean‐Paul; Fournier, Pierre-Édouard; Habib, Gilbert; Raoult, Didier; Thuny, Franck; Delahaye, François; Delahaye, A; Vandenesch, François; Donal, Erwan; Donnio, Pierre Yves; Flécher, Erwan; Michelet, Christian; Revest, Matthieu; Tattevin, Pierre; Chevalier, Florent; Jeu, Antoine; Rémadi, Jean Paul; Ruşinaru, Dan; Tribouilloy, Christophe; Bernard, Yvette; Chirouze, Catherine; Hoën, Bruno; Leroy, J.; Plésiat, Patrick; Neuerburg, Carl; Mazaheri, Bahram; Naber, Christoph; Athanasia, Carl Neuerburg Sophia; Deliolanis, Ioannis; Giamarellou, Helen; Trian, Thomas; Giannitsioti, Efthymia; Papanicolaou, Konstantinos; Mylona, Elena; Paniara, Olga; Παπανικολάου, Κωνσταντίνος; Pyros, John; Skoutelis, Athanasios; Sharma, Gautam; Francis, Johnson; Nair, Lathi; Thomas, Vinod; Venugopal, K.; Hannan, Margaret M.; Hurley, John P.; Wanounou, Maor; Gilon, Dan; Israel, Sarah; Korem, Maya; Rubinstein, Ethan; Strahilevitz, Jacob; Durante‐Mangoni, Emanuele; Iossa, Domenico; Orlando, Serena; Ursi, Maria Paola; Pafundi, Pia Clara; D’Amico, Fabiana; Bernardo, Mariano; Cuccurullo, Susanna; Dialetto, Giovanni; Covino, Franco Enrico; Manduca, Sabrina; Corte, Alessandro Della; Feo, Marisa De; Tripodi, Marie Françoise; Cecchi, Enrico; Rosa, Francesco De; Forno, Davide; Imazio, Massimo; Trinchero, Rita; Grossi, Paolo; Lattanzio, Mariangela; Toniolo, Antonio; Goglio, Antonio; Raglio, Alfredo; Ravasio, Veronica; Rizzi, Marco; Suter, Fredy; Carosi, Giampiero; Magri, Silvia; Signorini, Liana; Kanafani, Zeina A.; Kanj, Souha S.; Sharif‐Yakan, Ahmad; Abidin, Imran Zainal; Tamin, Syahidah Syed; Martínez, Eduardo Rivera; Nieto, Gabriel Israel Soto; Meer, J.T.M. van der; Chambers, Stephen; Holland, David; Morris, Arthur J.; Raymond, Nigel; Read, Kerry; Murdoch, David R.; Dragulescu, Stefan I.; Ionac, Adina; Mornos, C.; Butkevich, O.M.; Чипигина, Н. С.; Kirill, Ozerecky; Vadim, Kulichenko; Vinogradova, Tatiana; Edathodu, Jameela; Halim, Magid A.; Liew, Y.F.; Tan, Ru‐San; Lejko-Zupanc, Tatjana; Logar, Mateja; Mueller‐Premru, Manica; Commerford, Patrick; Commerford, Anita; Deetlefs, Eduan; Hansa, Cass; Ntsekhe, Mpiko; Almela, Manel; Ambrosioni, Juan; Azqueta, Manuel; Brunet, Mercè; Castro, Pedro López de; Lazzari, Elisa de; Falces, Carlos; Fuster, David; Fita, G.; Mària, C. García de la; García‐González, Javier; Gatell, José M.; Llopis, Jaume; Marco, Francesc; Miró, José M.; Moreno, Asunción; Ortiz, José M.; Ninot, Salvador Pié i; Paré, Juan C.; Pericàs, Juan M.; Quintana, Eduard; Ramírez, José; Rovira, I.; Sandoval, Elena; Sitges, Marta; Téllez, Adrián; Tolosana, José Marı́a; Vidal, Bárbara; Vilà, Jordi; Anguera, Ignasi; Font, Bernat; Gumà, Joan Raimón; Bermejo, Javier; Bouza, Emilio; Fernández, Miguel Ángel García; González-Ramallo, V.; Marı́n, Mercedes; Muñóz, Patricia; Pedromingo, Miguel; Roda, J.; Rodríguez‐Créixems, Marta; Solís, Jorge; Almirante, Benito; Fernández-Hidalgo, Núria; Tornos, Pilar; Alarcón, Arı́stides de; Parra, Ricardo; Alestig, Eric; Johansson, Magnus; Olaison, Lars; Snygg‐Martin, Ulrika; Pachirat, Orathai; Pachirat, Pimchitra; Pussadhamma, Burabha; Senthong, Vichai; Casey, Anna; Elliott, Tom; Lambert, Peter; Watkin, Richard; Eyton, Christina; Klein, John L.; Bradley, Suzanne F.; Kauffman, Carol A.; Bedimo, Roger; Chu, Vivian H.; Corey, G. Ralph; Crowley, Anna Lisa; Douglas, Pamela S.; Drew, Laura; Fowler, Vance G.; Holland, Thomas L; Lalani, Tahaniyat; Mudrick, Daniel W.; Samad, Zainab; Sexton, Daniel J.; Stryjewski, Martín E.; Wang, Andrew; Woods, Christopher W.; Lerakis, Stamatios; Cantey, Robert; Steed, Lisa L.; Wray, Dannah; Dickerman, Stuart; Bonilla, Hector; DiPersio, Joseph R.; Salstrom, Sara‐Jane; Baddley, John W.; Patel, Mukesh; Peterson, Gail; Stancoven, Amy B.; Levine, Donald P.; Riddle, Jonathan; Rybak, Michael J.; Cabell, Christopher H.

doi:10.1016/j.jacc.2021.02.014

Cited by 42 publications

(57 citation statements)

References 49 publications

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“…No randomized, controlled, or blinded trials were assessed. Only two studies were prospective cohort studies [ 15 , 16 ]; the remaining 11 studies employed retrospective cohort designs. Table 1 presents a summary of the study characteristics and reported outcomes [ 2 , 15–26 ].…”

Section: Resultsmentioning

confidence: 99%

“…Risk of bias was assessed using the NOS because all of the included studies used nonrandomized designs. Only two studies employed adequately representative exposed cohorts; their data were derived from a nationwide or multinational database [ 16 , 18 ]. All the included studies adequately reported the selection of the unexposed cohort and the determination of exposure and demonstrated that outcome of interest was not present at start of study.…”

Section: Resultsmentioning

confidence: 99%

“…All other studies lack descriptions about loss of follow up ( Table 3 ). Because all studies lack proper control for potential confounding factors, none of them get a credit in the comparability domain in NOS, and thus all included studies carried high risk of bias [ 16 ].…”

Section: Resultsmentioning

confidence: 99%

“…reported a lower probability of valve replacement surgery (OR: 0.82, 95% CI: 0.76–0.86) in patients with IE undergoing dialysis than in the other patients with IE; however, compared with the general population, the patients undergoing dialysis also had more comorbidities [ 9 ]. In a multinational, prospective International Collaboration on Endocarditis cohort (IE cohort), a lower likelihood of surgery for patients on dialysis was similarly observed (dialysis: 30.6% vs. non-dialysis: 46.2%; p < .001) [ 16 ]. Contraindication or high perioperative risk may also reduce the likelihood of surgical treatment.…”

Section: Discussionmentioning

confidence: 99%

“…However, during our review, hospital and surgery volume information were unavailable in all studies. Although the cardiac surgery volume of each study hospital may be retrieved indirectly from the Internet, such information would be unobtainable for nationwide databases or international registries [ 16 , 18 ]. Therefore, the outcomes could not be adjusted for surgery volume.…”

Section: Discussionmentioning

confidence: 99%

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Surgical versus medical treatment for infective endocarditis in patients on dialysis: a systematic review and meta-analysis

et al. 2022

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Infective endocarditis (IE) is a serious infection and causes significant morbidity and mortality. However, the benefit of surgery for endocarditis besides antibiotic treatment in dialysis patients remains controversial. We performed a systematic review of studies published between 1960 and February 2022. Meta-analysis was conducted with a random-effects model to explore the in-hospital, 30, 60, 90, 180-d, and 1-year mortality rates in adult dialysis patients with IE. Sensitivity analysis, subgroup analysis, and meta-regression were performed to explore potential sources of heterogeneity. Confidence of evidence was evaluated by the GRADE system. Thirteen studies were included. The pooled odds ratio of in-hospital mortality was 0.62 (95% confidence interval [CI]: 0.30–1.28, p = .17), with moderate heterogeneity ( I 2 = 62%, p < .01). Three studies reported 30-d mortality, and the pooled odds ratio for surgery compared with medical treatment was even lower (0.36; 95% CI: 0.22–0.61, p < .01), with low heterogeneity ( I 2 = 0%, p = .86). With studies on fewer than 30 patients excluded, the sensitivity analysis revealed a low odds ratio of in-hospital mortality for surgery versus medical treatment (0.52; 95% CI: 0.27–0.99, p = .047), with moderate heterogeneity ( I 2 = 63%, p < .01). Subgroup analysis revealed no significant differences between any two comparator subgroups. Based on a very low strength of evidence, compared with medical treatment, surgical treatment for IE in patients on dialysis is not associated with lower in-hospital mortality. When studies on fewer than 30 patients were excluded, surgical treatment was associated with better survival.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Surgical versus medical treatment for infective endocarditis in patients on dialysis: a systematic review and meta-analysis

et al. 2022

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ESC guidelines 2023 on the management of endocarditis

de Waha,

Desch,

Tilz

et al. 2023

Herz

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Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)

Hernández‐Meneses

Cuervo

Clara³

et al. 2023

Infect Dis Ther

Self Cite

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Introduction Infective endocarditis (IE) has undergone important changes in its epidemiology worldwide. Methods The study aimed to compare IE epidemiological features and outcomes according to predefined European regions and between two different time periods in the twenty-first century. Results IE cases from 13 European countries were included. Two periods were considered: 2000–2006 and 2008–2012. Two European regions were considered, according to the United Nations geoscheme for Europe: Southern (SE) and Northern–Central Europe (NCE). Comparisons were performed between regions and periods. A total of 4195 episodes of IE were included, 2113 from SE and 2082 from NCE; 2787 cases were included between 2000 and 2006 and 1408 between 2008 and 2012. Median (IQR) age was 63.7 (49–74) years and 69.4% were males. Native valve IE (NVE), prosthetic valve IE (PVE), and device-related IE were diagnosed in 68.3%, 23.9%, and 7.8% of cases, respectively; 52% underwent surgery and 19.3% died during hospitalization. NVE was more prevalent in NCE, whereas device-related IE was more frequent in SE. Higher age, acute presentation, hemodialysis, cancer, and diabetes mellitus all were more prevalent in the second period. NVE decreased and PVE and device-related IE both increased in the second period. Surgical treatment also increased from 48.7% to 58.4% ( p < 0.01). In-hospital and 6-month mortality rates were comparable between regions and significantly decreased in the second period. Conclusions Despite an increased complexity of IE cases, prognosis improved in recent years with a significant decrease in 6-month mortality. Outcome did not differ according to the European region (SE versus NCE). Graphical Abstract Supplementary Information The online version contains supplementary material available at 10.1007/s40121-023-00763-8.

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Infective Endocarditis in Patients on Chronic Hemodialysis

Cited by 42 publications

References 49 publications

Surgical versus medical treatment for infective endocarditis in patients on dialysis: a systematic review and meta-analysis

Surgical versus medical treatment for infective endocarditis in patients on dialysis: a systematic review and meta-analysis

ESC guidelines 2023 on the management of endocarditis

Epidemiological Changes and Improvement in Outcomes of Infective Endocarditis in Europe in the Twenty-First Century: An International Collaboration on Endocarditis (ICE) Prospective Cohort Study (2000–2012)

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