Infective endocarditis in patients with heart transplantation

Martínez‐Sellés, Manuel; Tattevin, Pierre; Valerio-Minero, Maricela; Alarcón, Arı́stides de; Fariñas, María Carmen; Mirabet‐Pérez, Sónia; Lavie‐Badie, Yoan; Ambrosi, Pı̈erre; Chabanne, Céline; Duval, Xavier; Lecomte, R.; López‐Vilella, Raquel; Uribarri, Aitor; Vinuesa, David; Muñóz, Patricia

doi:10.1016/j.ijcard.2020.12.018

Cited by 9 publications

(14 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Regarding immunosuppressed patients, Aspergillus , is overrepresented in patients with heart transplantation and infective endocarditis. In a French‐Spanish series for IE in those patients, Aspergillus was the cause of 18% of the episodes 21 . In HSCT cases with IE, Aspergillus caused 3/39 (7.7%) of the episodes 12 …”

Section: Discussionmentioning

confidence: 99%

Aspergillus endocarditis in the recent years, report of cases of a multicentric national cohort and literature review

Camici

Galar

Sousa

et al. 2022

Mycoses

Self Cite

View full text Add to dashboard Cite

Objectives (1) To describe the incidence, clinical characteristics, treatment and outcome of Aspergillus Endocarditis (AE) in a nationwide multicentric cohort (GAMES). (2) To compare the AE cases of the GAMES cohort, with the AE cases reported in the literature since 2010. (3) To identify variables related to mortality. Methods We recruited 10 AE cases included in the GAMES cohort (January 2008‐December 2018) and 51 cases from the literature published from January 2010 to July 2019. Results 4528 patients with infectious endocarditis (IE) were included in the GAMES cohort, of them 10 (0.2%) were AE. After comparing our 10 cases with the 51 of the literature, no differences were found. Analysing the 61 AE cases together, 55.7% were male, median age 45 years. Their main underlying conditions were as follows: prosthetic valve surgery (34.4%) and solid organ transplant (SOT) (19.7%). Mainly affecting mitral (36.1%) and aortic valve (29.5%). Main isolated species were as follows: Aspergillus fumigatus (47.5%) and Aspergillus flavus (24.6%). Embolisms occurred in 54%. Patients were treated with antifungals (90.2%), heart surgery (85.2%) or both (78.7%). Overall, 52.5% died. A greater mortality was observed in immunosuppressed patients (59.4% vs. 24.1%, OR = 4.09, 95%CI = 1.26–13.19, p = .02), and lower mortality was associated with undergoing cardiac surgery plus azole therapy (28.1% vs. 65.5%, OR = 0.22, 95%CI = 0.07–0.72, p = .01). Conclusions AE accounts for 0.2% of all IE episodes of a national multicentric cohort, mainly affecting patients with previous valvular surgery or SOT recipients. Mortality remains high especially in immunosuppressed hosts and azole‐based treatment combined with surgical resection are related to a better outcome.

show abstract

Section: Discussionmentioning

confidence: 99%

Aspergillus endocarditis in the recent years, report of cases of a multicentric national cohort and literature review

Camici

Galar

Sousa

et al. 2022

Mycoses

Self Cite

View full text Add to dashboard Cite

show abstract

“…This difference was accounted for exclusively by heart or combined heart and lung transplant recipients. An increased incidence of fungal endocarditis in heart transplant recipients has been confirmed in other studies [10,11 ▪ ].…”

Section: Etiologymentioning

confidence: 53%

“…In a multicenter study in the United States, the cumulative incidence of infective endocarditis in liver transplants was calculated at 1.7% [9]. Incidence density of infective endocarditis in heart transplant recipients has been calculated at 26–187 per 100 000 person years [10,11 ▪ ]. Martínez-Sellés et al [6 ▪▪ ] reported a similar incidence of infective endocarditis across all type SOTs performed in Spain between 2008 and 2018 of 0.19, 0.15 and 0.18% for kidney, liver, and heart/lung recipients, respectively.…”

Section: Epidemiologymentioning

confidence: 99%

See 1 more Smart Citation

Infective endocarditis in solid organ transplant: a review

Suárez

Subramanian

2022

Current Opinion in Organ Transplantation

View full text Add to dashboard Cite

Purpose of reviewInfective endocarditis remains an uncommon disease with significant morbidity and mortality. In the last two decades, progress has been made describing the unique aspects of infective endocarditis in solid organ transplant (SOT) recipients. Recent findingsIncidence of infective endocarditis in SOT is higher when compared with the general population. End-stage organ dysfunction, diabetes mellitus, older age, and prior intravenous lines have been identified as risk factors predisposing to infective endocarditis in SOT. Staphylococci and enterococci represent the most frequently isolated pathogens, whereas fungi are rarely isolated. Median time from transplantation to diagnosis ranges from 33 to 66 months. Nosocomial acquisition and mural endocarditis are more common in SOT recipients with infective endocarditis. Procurement of organs from patients with infective endocarditis might be well tolerated so long as close monitoring and targeted antibiotics are given. Selected patients might benefit from heart transplantation as definitive or salvage therapy for infective endocarditis. Outcomes of infective endocarditis in SOT recipients compared with the general population might be similar; however, patient survival and graft function are reduced when recipients suffer from infective endocarditis.

show abstract

“… 11 Historically, it has been associated with adult infective endocarditis. 12 , 13 Although Streptococcus gallolyticus was once considered an uncommon cause of neonatal infections, there has been a noticeable shift over the past decade. An increasing number of reports of neonatal sepsis, meningitis, and intrauterine infections caused by S. gallolyticus have been observed.…”

Section: Introductionmentioning

confidence: 99%

Late-Onset Meningitis in a Preterm Infant Caused by Streptococcus gallolyticus Subsp. Pasteurianus in Saudi Arabia: A Case Report and Literature Review

Al-shehri

2023

IMCRJ

View full text Add to dashboard Cite

This report describes the progression of meningitis in a 24-day-old preterm male infant infected with Streptococcus gallolyticus subsp. pasteurianus (SGSP) and its medical care, pathogen detection, antibiotic treatment, and monitoring, ultimately leading to a positive outcome of successful recovery. Neonatal meningitis (NM) is a serious and potentially life-threatening condition, particularly in immunocompromised preterm infants. This report from Saudi Arabia presents a rare case of late-onset neonatal meningitis caused by SGSP in a preterm male infant. The 24-day-old preterm neonate presented with fever, lethargy, poor feeding, and respiratory distress. SGSP was confirmed by cerebral spinal fluid analysis showing the presence of pleocytosis and a low glucose ratio. Prompt antibiotic therapy with intravenous Ampicillin and Cefotaxime led to decreased pleocytosis, and the infant was discharged after 21 days. This report highlights the importance of vigilance, diagnosis, and management of neonatal infections caused by uncommon pathogens such as SGSP. The rarity of SGSP-caused meningitis emphasizes the need to monitor pregnant women for potential transmission and to implement early diagnostic and management strategies. This case report also encompasses a review of recent globally reported cases of neonatal S. gallolyticus infection, highlighting the distinctiveness of this report as the first of its type in Saudi Arabia.

show abstract

Infective endocarditis in patients with heart transplantation

Cited by 9 publications

References 18 publications

Aspergillus endocarditis in the recent years, report of cases of a multicentric national cohort and literature review

Aspergillus endocarditis in the recent years, report of cases of a multicentric national cohort and literature review

Infective endocarditis in solid organ transplant: a review

Late-Onset Meningitis in a Preterm Infant Caused by Streptococcus gallolyticus Subsp. Pasteurianus in Saudi Arabia: A Case Report and Literature Review

Contact Info

Product

Resources

About