Infecton: a 99mTc-ciprofloxacin radiopharmaceutical for the detection of bone infection

Malamitsi, J.; Giamarellou, Helen; Kanellakopoulou, K.; Dounis, Eleftherios; Grecka, V.; Christakopoulos, J.; Koratzanis, George; Antoniadou, Anastasia; Panoutsopoulos, Georgios I.; Batsakis, Christos; Proukakis, C.

doi:10.1046/j.1469-0691.2003.00506.x

Cited by 46 publications

(31 citation statements)

References 11 publications

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“…Some research groups have demonstrated good results in favor of imaging infections with using Tc-99m ciprofloxacin [2,3,[13][14][15][16][17][18][19][20][21][22][23]. Further, case reports have been published on the use of Tc-99m ciprofloxacin for many different illnesses: osteomyelitis of the axial skeleton and hip joint [24,25], tuboovarian abscess [12], acute bacterial prostatitis [10], seminal vesiculitis caused by chlamydia [11], renal abscess [26], infectious spondylodiscitis [27,28], evaluating the response of postsurgical bony infection to antibiotic therapy [29], and the absence of uptake by infection in a renal abscess [30].…”

Section: Discussionmentioning

confidence: 99%

Tc-99m Ciprofloxacin SPECT of Pulmonary Tuberculosis

Lee

Yoon²,

Hwang

et al. 2010

Nucl Med Mol Imaging

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Introduction: Acute pulmonary embolism (PE) is a common cause of death in hospital patients. CTPA is a widely used modality for diagnosis, but its sensitivity is probably less than reported. We present two patients with CTPA negative and V/Q SPECT positive results. These case examples suggest a continued role for the radionuclide technique. Method: Patient 1 was a 57-year-old woman with a past history of Right TKR 3/52 who presented with dyspnoea/chest pain/positive D-dimer. Her investigations revealed a negative CTPA, however her V/Q SPECT performed 1 day after the CT showed mismatched defects in left lower lobe. (Figures 1-4) Patient 2 was a 22-year-old male with a past history of large DVT in left leg/recent spinal surgery. His investigation also revealed a negative CTPA, however his V/Q performed 3 days post CTPA revealed multiple pulmonary emboli. In both cases the positive V/Q SPECT was considered more consistent with the presentation and pre-test likelihood and the patients were treated accordingly. Results: In recent years, CTPA has been widely promoted as the technique of choice for the investigation of acute PE. However, published data indicate that the sensitivity of the procedure can vary from 68-94.1%. The advent of V/Q SPECT has raised the diagnostic accuracy of this technique suffi cient for it to represent an adequate alternative to CTPA. Our case examples also highlight the need to consider imaging results in the clinical context and reinforce the message that discordant pre-test likelihood and test results should lead to further consideration. In this circumstance, our case series emphasise that V/Q SPECT can identify acute PE when the CTPA is negative. Conclusion: The sensitivity of CTPA may be less than previously suggested. V/Q SPECT is an excellent alternative when the CTPA result is discordant with pre-test likelihood. Introduction: Perfusion scans may be affected by residual activity from the preceding ventilation study if a technetium-based radioaerosol is used. Subtraction of the ventilation scan is a technique that can improve defect contrast of PE and is used for generation of quantitative data, such as V/Q quotient images. The aim of the study was to determine whether ventilation subtraction could introduce artefacts in perfusion SPECT scans in patients considered not to have pulmonary embolism (PE). Methods: 38 patients with normal/near normal V/Q SPECT scans and low clinical likelihood of PE were included. For each patient, ventilation SPECT scans (using Technegas) were compared to Tc99m-MAA perfusion SPECT scans with (i) residual background ventilation (Q) and (ii) background subtraction (Q-V). For each ventilation and perfusion pair, 2 experienced observers assessed the location and size of any mismatched (or matched) perfusion defects, assigned a diagnostic category using EANM reporting guidelines, and noted whether the clinical read of the standard V/Q study differed from the V/(Q-V) data. Results: Of the 38 patients included, 37 (97%) were assigned to the same EANM diagnostic ...

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Section: Discussionmentioning

confidence: 99%

Tc-99m Ciprofloxacin SPECT of Pulmonary Tuberculosis

Lee

Yoon²,

Hwang

et al. 2010

Nucl Med Mol Imaging

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“…[152][153][154][155][156][157][158] However, also critical results have been reported; e.g. significant accumulation in noninfected prosthetic joints and the inability to discriminate between infected and aseptic osteoarticular disease in patients.…”

Section: Figurementioning

confidence: 99%

Development and Prospects of Dedicated Tracers for the Molecular Imaging of Bacterial Infections

et al. 2013

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Abstract:Bacterial infections have always been, and still are, a major global healthcare problem. For accurate treatment it is of upmost importance that the location(s), severity, type of bacteria, and therapeutic response can be accurately staged. Similar to the recent successes in oncology, tracers specific for molecular imaging of the disease may help advance the patient management. Chemical design and bacterial targeting mechanisms are the basis for the specificity of such tracers. The aim of this review is to provide a comprehensive overview of the molecular imaging tracers developed for optical and nuclear identification of bacteria and bacterial infections. Hereby we envision that such tracers can be used to diagnose infections and aid their clinical management. From these compounds we have set-out to identify promising targeting mechanisms and select the most promising candidates for further development.

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“…For example, bacterial osteoarticular infective imaging using infecton was studied, but it did not discriminate between infected and aseptic osteoarticular diseases [32]. On the other hand, infecton scintigraphy detected bone infection in several studies [32][33][34]. Thus, infecton was demonstrated to be a very sensitive and quite specific a marker of bone infection imaging and but false-positive results might be obtained in cases of excessive new bone formation and primary bone tumors [33].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, infecton scintigraphy detected bone infection in several studies [32][33][34]. Thus, infecton was demonstrated to be a very sensitive and quite specific a marker of bone infection imaging and but false-positive results might be obtained in cases of excessive new bone formation and primary bone tumors [33]. In another study, Sharma et al represented that infecton might be used for detecting tubercular bone disease [34,35].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of 99mTc-labeled antibiotics for infection detection

Yurt

2010

Ann Nucl Med

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One of the fields of research in nuclear medicine is the development of new radiopharmaceuticals for imaging infection and inflammation in humans. For this development, several antimicrobial peptides, antibiotics, antibiotic peptide and chemotactic peptides, etc., have been radiolabeled with different radionuclides (⁶⁷Ga, ⁹⁹(m)Tc, ¹¹¹In, ¹⁸F, ¹³¹I, etc.) and their imaging potentials studied. Actually, it is very important to distinguish between infection and inflammation. In this respect, radiolabeled antibiotics have advantages because many of the properties of the ideal infection-specific agent through antibiotics localizes in infection site. In this review, only ⁹⁹(m)Tc-labeled antibiotics are evaluated and discussed.

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Infecton: a 99mTc-ciprofloxacin radiopharmaceutical for the detection of bone infection

Abstract: It is concluded that Infecton is a very sensitive and quite specific marker of bone infection, but care must be taken in cases of excessive new bone formation and primary bone tumors, where false-positive results may be obtained.

Cited by 46 publications

References 11 publications

Tc-99m Ciprofloxacin SPECT of Pulmonary Tuberculosis

Tc-99m Ciprofloxacin SPECT of Pulmonary Tuberculosis

Development and Prospects of Dedicated Tracers for the Molecular Imaging of Bacterial Infections

Evaluation of 99mTc-labeled antibiotics for infection detection

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