The nuclear electric dipole (E1) polarizability (α
E1) is mainly dominated by the dynamics of the giant dipole resonance (GDR). α
E1 is proportional to the (-2) moment of the total photo nuclear cross-section (σ
−2). This research investigates the relationship between α
E1 and σ
−2, along with the effects of the Pygmy Dipole Resonance (PDR) and GDR in odd-mass actinide nuclei. For the first time, α
E1 and σ
−2 values have been calculated using the Translational and Galilean Invariant Quasiparticle Phonon Nuclear Model (TGI-QPNM) approach for odd-A actinide nuclei. According to TGI-QPNM results, E1 dipole transitions in the GDR region significantly contribute to σ
−2 due to the energy weighting factor. Below the neutron separation threshold, the PDR in neutron-rich nuclei shows a contribution of about 5% to σ
−2 values. In this region, E1 polarizability can reach values of 20%–25%. The α
E1 values indicate the presence of PDR in these nuclei. Additionally, the Adaptive Neuro-Fuzzy Inference System (ANFIS), a new machine learning method, has been performed to analyze the relationship between α
E1 and σ
−2. The ANFIS results have been compared with those from the TGI-QPNM and experimental data. The TGI-QPNM model achieves an R2 of 0.85–0.95, while the ANFIS model achieves an R2 of 0.99. Moreover, the study suggests that the ANFIS model, consistent with TGI-QPNM results, could be an effective tool for estimating σ
−2 in odd-A actinide nuclei.