“…Practically all endodontic procedures, such as local anesthesia administration (Garisto et al, 2010), root canal preparation and irrigation (Guivarc'h et al, 2017), root canal filling (Rosen et al, 2016), and surgical endodontic treatments (Kim & Kratchman, 2006;Moiseiwitsch, 1995;Alves et al, 2014), that are performed in the vicinity of trigeminal nerve branches may trigger nerve injury (Rosen et al, 2016;Yatsuhashi et al, 2003). Many non-endodonticrelated entities such as infectious diseases, trauma, tumors, or idiopathic diseases have also been suggested as possible origins of altered sensation of trigeminal nerve branches (Divya et al, 2010), and should be regarded as a differential diagnosis for endodontic treatment related nerve injury (Rosen, 2014;Gallas-Torreira et al, 2003;Givol et al, 2011;Pogrel, 2007;Tilotta-Yasukawa et al, 2006).…”