Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive Control

Schmidt, André; Walter, Marc; Gerber, Helmut; Schmid, Otto; Smieskova, Renata; Bendfeldt, Kerstin; Wiesbeck, Gerhard A.; Riecher-Rössler, Anita; Lang, Undine E.; Rubia, Katya; McGuire, Philip; Borgwardt, Stefan

doi:10.1038/npp.2013.123

Cited by 54 publications

(38 citation statements)

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“…In a recent study, we could show that heroin impairs stimulus-driven attention allocation, as indicated by reduced activity in the right inferior frontal gyrus (39). Further studies showed that loss of control over drug intake is not only a result of disrupted subcortical reward circuits but also of prefrontal higher-order executive functions (40).…”

Section: Discussionmentioning

confidence: 95%

Association of Frontal Gray Matter Volume and Cerebral Perfusion in Heroin Addiction: A Multimodal Neuroimaging Study

et al. 2013

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Structure and function are closely related in the healthy human brain. In patients with chronic heroin exposure, brain imaging studies have identified long-lasting changes in gray matter (GM) volume. More recently, we showed that acute application of heroin in dependent patients results in hypoperfusion of fronto-temporal areas compared with the placebo condition. However, the relationship between structural and cerebral blood flow (CBF) changes in heroin addiction has not yet been investigated. Moreover, it is not known whether there is any interaction between the chronic structural changes and the short and long-term effects on perfusion caused by heroin. Using a double-blind, within-subject design, heroin or placebo (saline) was administered to 14 heroin-dependent patients from a stable heroin-assisted treatment program, in order to observe acute short-term effects. Arterial spin labeling (ASL) was used to calculate perfusion quantification maps in both treatment conditions, while Voxel-Based Morphometry (VBM) was conducted to calculate regional GM density. VBM and ASL data were used to calculate homologous correlation fields by Biological Parametric Mapping (BPM) and a whole-brain Pearson r correlation. We correlated each perfusion condition (heroin and placebo) separately with a VBM sample that was identical for the two treatment conditions. It was assumed that heroin-associated perfusion is manifested in short-term effects, while placebo-associated perfusion is more related to long-term effects. In order to restrict our analyses to fronto-temporal regions, we used an explicit mask for our analyses. Correlation analyses revealed a significant positive correlation in frontal areas between GM and both perfusion conditions (heroin and placebo). Heroin-associated perfusion was also negatively correlated with GM in the inferior temporal gyrus on both hemispheres. These findings indicate that, in heroin-dependent patients, low GM volume is positively associated with low perfusion within frontal regions.

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Section: Discussionmentioning

confidence: 95%

Association of Frontal Gray Matter Volume and Cerebral Perfusion in Heroin Addiction: A Multimodal Neuroimaging Study

et al. 2013

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“…However, most of the available data is focused on the role of a few frontal regions and of their connected subcortical structures, especially those of the corticobasal ganglia loop (Aron and Poldrack, 2006;Li et al, 2006;Schmidt et al, 2013;Vink et al, 2005). The suggested absence of any role for the parietal lobe, stemming from neurophysiological studies using the Go/No-Go task (Kalaska and Crammond, 1995), could be attributed to the fact that in successful trials of both tasks no movement is required and therefore, on the overall theoretical perspective (Scheme 1) adopted by this paper, on-line control/update of the movement trajectory is not required.…”

Section: Neurophysiological Studies In Animalsmentioning

confidence: 99%

Correction and suppression of reaching movements in the cerebral cortex: Physiological and neuropsychological aspects

Battaglia-Mayer

Buiatti

Caminiti

et al. 2014

Neuroscience & Biobehavioral Reviews

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Modification or suppression of reaches occurs in everyday life. We argue that a common modular architecture, based on similar neural structures and principles of kinematic and kinetic control, is used for both direct reaches and for their on-line corrections. When a reach is corrected, both the pattern of neural activity in parietal, premotor and motor cortex and the muscle synergies associated with the first movement can be smoothly blended or sharply substituted into those associated with the second one. Premotor cortex provides the early signaling for trajectory updating, while parietal and motor cortex provide the fine-grained encoding of hand kinematics necessary to reshape the motor plan. The cortical contribution to the inhibitory control of reaching is supported by the activity of a network of frontal areas. Premotor cortex has been proposed as a key structure for reaching suppression. Consistent with this, lesions in different nodes of this network result in different forms of motor deficits, such as Optic Ataxia in parietal patients, and commission errors in frontal ones.

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“…More generally, our findings also contribute to a growing body of literature in which neuro imaging measures are used to evaluate the outcome of therapies for heroin addiction. 7,[30][31][32][33][34] The SN plays a role in salience detection and attention capture induced by error signals and dynamic cognitive control.…”

Section: Discussionmentioning

confidence: 99%

Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men

Liu

Wang

et al. 2018

jpn

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IntroductionCognitive dysfunction is a key component of addictive disorders. With heroin addiction, specific deficits in salience attribution and inhibitory control emerge during long-term drug abuse and promote heroin relapse during withdrawal.1 Although most heroin-dependent individuals are willing to quit, available interventions for heroin addiction have shown only limited efficacy so far. Methadone maintenance treatment programs (MMTPs) are a common treatment approach thought to be effective for heroin addiction; however, the heroin-dependent patients in MMTPs are at high risk for relapse, with about 70% of individuals relapsing once they leave such a program.2 Despite the high relapse rate, few neuroimaging studies so far have addressed the neural predictors of risk for heroin relapse. Studies using task-related functional MRI (fMRI) have shown some usefulness in identifying relapse predictors 3-5 or quitting predictors. 6,7 For example, a previous study by our group showed that drugrelated cues induced activity of the nucleus accumbens/ subcallosal cortex and that the cerebellum was associated with subsequent relapse in heroin-dependent individuals. 3Brain activity associated with error processing was shown to predict relapse in cocaine-dependent patients.4 Disrupted ventromedial prefrontal function was shown to be associated with relapse in alcohol-dependent patients.5 Greater response of the medial prefrontal cortex and precuneus to self-related tailored smoking-cessation messages was shown to be associated with quitting. 6 And pretreatment medial prefrontal cortical response to heroin-related cues was shown to be associated with greater adherence to injectable extended-release naltrexone.7 However, more effective imaging markers that We conducted a prospective resting-state functional MRI study comparing the functional connectivity strength among healthy controls and heroin-dependent men who had either relapsed or were in early remission. Men were considered to be either relapsed or in early remission based on urine drug screens during a 3-month follow-up period. We also examined how the coupling of large-scale networks correlated with relapse behaviour among heroin-dependent men. Results: We included 20 controls and 50 heroin-dependent men (26 relapsed and 24 early remission) in our analyses. The relapsed men showed greater connectivity than the early remission and control groups between the dorsal anterior cingulate cortex (key node of the SN) and the dorsomedial prefrontal cortex (included in the DMN). The relapsed men and controls showed lower connectivity than the early remission group between the left dorsolateral prefrontal cortex (key node of the left ECN) and the dorsomedial prefrontal cortex. The percentage of positive urine drug screens positively correlated with the coupling between the dorsal anterior cingulate cortex and dorsomedial prefrontal cortex, but negatively correlated with the coupling between the left dorsolateral prefrontal cortex and dorsomedial prefrontal cortex. Limitations:...

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Inferior Frontal Cortex Modulation with an Acute Dose of Heroin During Cognitive Control

Cited by 54 publications

References 50 publications

Association of Frontal Gray Matter Volume and Cerebral Perfusion in Heroin Addiction: A Multimodal Neuroimaging Study

Association of Frontal Gray Matter Volume and Cerebral Perfusion in Heroin Addiction: A Multimodal Neuroimaging Study

Correction and suppression of reaching movements in the cerebral cortex: Physiological and neuropsychological aspects

Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men

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