Inferior tendon graft to bone tunnel healing at the tibia compared to that at the femur after anterior cruciate ligament reconstruction

Lui, Pauline Po Yee; Ho, Grace; Shum, Wai Ting; Lee, Wayne; Ho, P Y; Lo, Wing Nin; Lo, Chun Kwong

doi:10.1007/s00776-010-1460-6

Cited by 36 publications

(45 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Eighty-four male Sprague Dawley rats (12 weeks, mean weight: 440 ± 21 g) were used. ACL reconstructions were performed as described previously (Lui et al, 2010b;Lui et al, 2011). Animals were sedated by intramuscular injection of 10 % ketamine/2 % xylazine (Kethalar, 0.3 mL: 0.2 mL) and sedation was maintained with 10 % ketamine injected intravenously (Sigma-Aldrich, St Louis, MO, USA).…”

Section: Animal Operationmentioning

confidence: 99%

“…A cone-beam vivaCT (computed tomography) system (VivaCT40, Scanco Medical AG, Bassersdorf, Switzerland) was used to assess the bone mass and density of mineralised tissue inside the bone tunnels and the peri-tunnel bone at the knee region as described previously (Lui et al, 2010b).…”

Section: Vivact Imaging and Data Analysismentioning

confidence: 99%

“…The samples were fixed in 4 % neutral buffered formalin, decalcified in 9 % formic acid for about 4-6 weeks with the exact time determined by X-ray and embedded in paraffin as described previously (Lui et al, 2010b;Lui et al, 2011). The femoral and tibial tunnel complexes were divided into two, with the graft mid-substance preserved and attached to the tibial tunnel.…”

Section: Histologymentioning

confidence: 99%

“…There was significant reversible decrease in BMD around the knee joint as measured by dual-energy X-ray absorptiometry (DXA) in patients undergoing ACL reconstruction in a randomised controlled trial comparing bone loss with different surgical techniques (Lui et al, 2012). In a study using a rabbit ACL reconstruction model, the averaged femoral and tibial tunnel diameters did not change up to week 12 as compared to that at baseline with the progression of healing, implying that bone resorption was fast (Lui et al, 2010b).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction

Lui

Lee²,

Mok³

et al. 2013

eCM

View full text Add to dashboard Cite

Peri-tunnel bone loss after anterior cruciate ligament (ACL) reconstruction is commonly observed, both clinically and experimentally. We aimed to study the effect and mechanisms of different doses of alendronate in the reduction of peritunnel bone loss and promotion of graft-bone tunnel healing in ACL reconstruction. Eighty-four ACL-reconstructed rats were divided into 4 groups. Alendronate at different dosages, or saline, were injected subcutaneously weekly, for 2 or 6 weeks post-reconstruction, for vivaCT (computed tomography) imaging, biomechanical tests, histology and immunohistochemistry. Alendronate significantly increased bone mass and density of tissue inside bone tunnels except at the epiphyseal region of tibial tunnel. The femoral tunnel diameter decreased significantly in the mid-dose and highdose alendronate groups compared to that in the saline group at week 6. Alendronate significantly increased the peri-tunnel bone mass and density along all tunnel regions at week 6. Better graft-bone tunnel integration and intra-tunnel graft integrity were observed in the alendronate groups. The ultimate load was significantly higher in the mid-dose and high-dose alendronate groups at week 2, but not at week 6. There was a reduction in matrix metalloprotein (MMP)1, MMP13 and CD68-positive cells at the peri-tunnel region and graft-bone interface in the alendronate-treated group compared to the saline group. Alendronate reduced peritunnel bone resorption, increased mineralised tissue inside bone tunnel as well as histologically and biomechanically promoted graft-bone tunnel healing, probably by reducing the expression of MMP1, MMP13 and CD68-positive cells. Alendronate might be used for reducing peri-tunnel bone loss and promoting graft-bone tunnel healing at early stage post-ACL reconstruction.

show abstract

Section: Animal Operationmentioning

confidence: 99%

Section: Vivact Imaging and Data Analysismentioning

confidence: 99%

Section: Histologymentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction

Lui

Lee²,

Mok³

et al. 2013

eCM

View full text Add to dashboard Cite

show abstract

“…Bone tunnel enlargement is a commonly seen phenomenon after ACL reconstruction, but its exact causes are still under debate 6,7 . Most likely it is multifactorial due to both mechanical and biological causes.…”

mentioning

confidence: 99%

In vivo bone tunnel remodeling in symptomatic patients after ACL reconstruction: a retrospective comparison of articular and extra-articular fixation

Dominic¹

2015

MLTJ

View full text Add to dashboard Cite

SummaryBackground: there is only a paucity of studies dealing with bone remodeling within the tunnels after anterior cruciate ligament (ACL) reconstruction. The objective of this study was to evaluate the influence of tendon graft type and surgical fixation technique on bone tunnel remodeling in patients with symptomatic knees after ACL reconstruction. Methods: in a retrospective study 99mTc-HDP bone tracer uptake (BTU) in SPECT/CT of 57 knees with symptoms of pain and/or instability after ACL reconstruction was investigated. All 57 knees were subdivided according their anatomy (femur and tibia), fixation (articular versus extraarticular fixation) and graft types into eight groups: femoral-articular versus extra-articular fixation using bone-patellar tendon-bone (BPTB) and hamstring autografts; tibial-articular versus extra-articular fixation using patellar tendon and hamstring autografts; BTU grading for each area of the localisation scheme were recorded. Tunnel diameter and length was measured in the CT scans. Results: BTU was higher for the articular fixation in the femur and for the extra-articular fixation in the tibial tunnel. Patellar tendon graft fixation showed a significantly higher BTU in the superior-lateral and posterior-central area of the tibia,

show abstract

In vivo bone tunnel evaluation of nanoparticle‐grafts using an ACL reconstruction rabbit model

Grant

Smith²,

Schmidt³

et al. 2017

J Biomedical Materials Res

View full text Add to dashboard Cite

Acellular human gracilis tendons conjugated with gold nanoparticles (AuNP) and hydroxyapatite nanoparticles (nano-HAp) were used as a graft in an anterior cruciate ligament (ACL) reconstruction rabbit model. The ACLs of 11 New Zealand rabbits were reconstructed using grafts conjugated without nanoparticles, with AuNP only, and with both AuNP and nano-HAp. Semi-quantitative histological scoring of bone tunnel portion of grafts was performed after 14 weeks. Bone tunnels were scored for graft degeneration, graft remodeling, percentage of new host fibrous connective, collateral connection, head-to-head connection, graft collagen fiber organization, new host fibrous connective tissue organization, and graft and interface vascularity. All grafts were intact at 14 weeks. Results of bone tunnel scoring indicate remodeling in all graft types with new organized host fibrous connective tissue, head-to-head connection to bone and mild inflammation associated with remodeling. Components of the 20 nm AuNP grafts have significantly more graft degeneration, more new host fibrous connective tissue, and more vascularity compared to crosslinked grafts. Comparison between femoral and tibial tunnel scores indicate more degeneration in femoral tunnels compared to tibial tunnels. Overall results indicated potentially enhanced remodeling from the use of 20 nm AuNP grafts. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 1071-1082, 2017.

show abstract

Inferior tendon graft to bone tunnel healing at the tibia compared to that at the femur after anterior cruciate ligament reconstruction

Cited by 36 publications

References 28 publications

Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction

Alendronate reduced peri-tunnel bone loss and enhanced tendon graft to bone tunnel healing in anterior cruciate ligament reconstruction

In vivo bone tunnel remodeling in symptomatic patients after ACL reconstruction: a retrospective comparison of articular and extra-articular fixation

In vivo bone tunnel evaluation of nanoparticle‐grafts using an ACL reconstruction rabbit model

Contact Info

Product

Resources

About