Inferior vena cava injuries - a clinical review

Rehman, Zia Ur

doi:10.5455/jpma.21107

Cited by 16 publications

(16 citation statements)

References 20 publications

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“…Such patients may also suffer from infection and humid gangrene or even die. Studies have shown that the GCS score, intraoperative hemodynamic status, and the presence of free blood in the abdominal cavity are factors that influence the patients' conditions [ 16 ].…”

Section: Complications Prognosis and Mortality Predictors Of Ivc Injuriesmentioning

confidence: 99%

Clinical Manifestations of Inferior Vena Cava Injuries and the Progress of Emergency Treatment

Liu

Zhang

Xiang³

et al. 2022

Journal of Healthcare Engineering

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In this paper, clinical manifestations of inferior vena cava injuries and the progress of emergency treatment are presented. Inferior vena cava (IVC) is the large vein returning venous blood from the lower limbs and pelvic and abdominal cavities to the right atrium of the heart. The clinical manifestations of IVC injuries include shock, progressive hemorrhage, air embolism, retroperitoneal hematoma, active bleeding, and hemoperitoneum. The patients may be combined or not combined with injuries to other organs or even die. Routine examination methods for IVC injuries include general examination, color Doppler ultrasound, abdominal contrast-enhanced CT, magnetic resonance spectroscopic imaging (MRSI), and IVC angiography. These examinations are usually performed to confirm the diagnosis. Surgical treatment is the primary emergency treatment for this condition. Increasing the blood volume and symptomatic treatment are auxiliary treatments. The surgeries and repairs for IVC injuries are currently under investigation. Experimental results have verified the exceptional performance of the proposed scheme.

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Section: Complications Prognosis and Mortality Predictors Of Ivc Injuriesmentioning

confidence: 99%

Clinical Manifestations of Inferior Vena Cava Injuries and the Progress of Emergency Treatment

Liu

Zhang

Xiang³

et al. 2022

Journal of Healthcare Engineering

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“…Asthma is a common disease with globally high morbidity, mortality, and economic burden. 22 Asthma is a heterogeneous disease associated with many factors, such as infections, tobacco smoke, cold air, allergens, hormones, exercise, obesity, genetic mutations, and eosinophilia. [23][24][25][26] Meanwhile, asthma is also associated with chronic airway inflammation caused by activation of the immune system.…”

Section: Ctrp3 Alleviated Inflammation In Balf Of Ovastimulated Micementioning

confidence: 99%

CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA

2023

Allergol Immunopathol

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Background: Asthma is a common illness with chronic airway inflammation. C1q/tumor necrosis factor (TNF)-related protein 3 (CTRP3) plays a vital role in inflammatory response, but its effect on asthma is imprecise. Herein, we analyzed the functions of CTRP3 in asthma. Methods: The BALB/c mice were randomized into four groups: control, ovalbumin (OVA), OVA+vector, and OVA+CTRP3. The asthmatic mice model was established by OVA stimulation. Overexpression of CTRP3 was implemented by the transfection of corresponding adeno-associated virus 6 (AAV6). The contents of CTRP3, E-cadherin, N-cadherin, smooth muscle alpha-actin (α-SMA), phosphorylated (p)-p65/p65, transforming growth factor-beta 1 (TGFβ1), and p-Smad3/Smad3 were determined by Western blot analysis. The quantity of total cells, eosinophils, neutrophils, and lymphocytes in bronchoalveolar lavage fluid (BALF) was assessed by using a hemocytometer. The contents of tumor necrosis factor-α and interleukin-1β in BALF were examined by enzyme-linked immunesorbent serologic assay. The lung function indicators and airway resistance (AWR) were measured. The bronchial and alveolar structures were evaluated by hematoxylin and eosin staining and sirius red staining. Results: The CTRP3 was downregulated in mice of OVA groups; however, AAV6-CTRP3 treatment markedly upregulated the expression of CTRP3. Upregulation of CTRP3 diminished asthmatic airway inflammation by decreasing the number of inflammatory cells and the contents of proinflammatory factors. CTRP3 markedly lessened AWR and improved lung function in OVA-stimulated mice. Histological analysis found that CTRP3 alleviated OVA-induced airway remodeling in mice. Moreover, CTRP3 modulated NF-κB and TGFβ1/Smad3 pathways in OVA-stimulated mice. Conclusion: CTRP3 alleviated airway inflammation and remodeling in OVA-induced asthmatic mice via regulating NF-κB and TGFβ1/Smad3 pathways.

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“…However, the application of such EBCPGs in Pakistan presents a problem, as the landscape of respiratory conditions differs in many aspects. These include but are not limited to epidemiology [ 4 ], genetic variability [ 10 ], healthcare financing and access [ 11 ], triggers and risk factors [ 12 ], socio-cultural influences [ 13 ], disease related awareness [ 14 ]. In addition, there is a lack of specialist pulmonologists in Pakistan, particularly in rural areas.…”

Section: Introductionmentioning

confidence: 99%

GRADE-ADOLOPMENT of clinical practice guidelines and creation of clinical pathways for the primary care management of chronic respiratory conditions in Pakistan

et al. 2023

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Introduction In Pakistan, chronic respiratory conditions contribute a large burden of morbidity and mortality. A major reason for this is the lack of availability of local evidence-based clinical practice guidelines (EBCPGs) in Pakistan, particularly at the primary care level. Thus, we developed EBCPGs and created clinical diagnosis and referral pathways for the primary care management of chronic respiratory conditions in Pakistan. Methods The source guidelines were selected by two local expert pulmonologists after a thorough literature review on PubMed and Google Scholar from 2010 to December 2021. The source guidelines covered idiopathic pulmonary fibrosis, asthma, chronic obstructive pulmonary disorders, and bronchiectasis. The GRADE-ADOLOPMENT process consists of three key elements: adoption (using recommendations as is or with minor changes), adaptation (effective context-specific changes to recommendations) or additions (including new recommendations to fill a gap in the EBCPG). We employed the GRADE-ADOLOPMENT process to adopt, adapt, adopt with minor changes, or exclude recommendations from a source guideline. Additional recommendations were added to the clinical pathways based on a best-evidence review process. Results 46 recommendations were excluded mainly due to the unavailability of recommended management in Pakistan and scope beyond the practice of general physicians. Clinical diagnosis and referral pathways were designed for the four chronic respiratory conditions, explicitly delineating the role of primary care practitioners in the diagnosis, basic management, and timely referral of patients. Across the four conditions, 18 recommendations were added (seven for IPF, three for bronchiectasis, four for COPD, and four for asthma). Conclusion The widespread use of the newly created EBCPGs and clinical pathways in the primary healthcare system of Pakistan can help alleviate the morbidity and mortality related to chronic respiratory conditions disease in the country.

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Inferior vena cava injuries - a clinical review

Cited by 16 publications

References 20 publications

Clinical Manifestations of Inferior Vena Cava Injuries and the Progress of Emergency Treatment

Clinical Manifestations of Inferior Vena Cava Injuries and the Progress of Emergency Treatment

CTRP3 regulates NF-κB and TGFβ1/Smad3 pathways to alleviate airway inflammation and remodeling in asthmatic mice induced by OVA

GRADE-ADOLOPMENT of clinical practice guidelines and creation of clinical pathways for the primary care management of chronic respiratory conditions in Pakistan

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