2024
DOI: 10.1103/prxlife.2.043020
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Inferring Nonlinear Dynamics of Cell Migration

Pedrom Zadeh,
Brian A. Camley

Abstract: The motility of eukaryotic cells is strongly influenced by their environment, with confined cells often developing qualitatively different motility patterns from those migrating on simple two-dimensional substrates. Recent experiments, coupled with data-driven methods to extract a cell's equation of motion, showed that cancerous MDA-MB-231 cells persistently hop in a limit cycle when placed on two-state adhesive micropatterns (two large squares connected by a narrow bridge), while they remain stationary on ave… Show more

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