Infertile women with and without endometriosis: A case control study of luteal phase and other infertility conditions

Matorras, Roberto; Rodrı́guez, Fernando; Pérez, Carlos Enrique Tene; Pijoán, José Ignacio; Neyro, José Luís; Rodriguez-Escudero, F.J.

doi:10.3109/00016349609054711

Cited by 18 publications

(11 citation statements)

References 28 publications

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“…Others [8,9] found significantly higher basal PRL levels in patients with infertility and endometriosis. Brosens et al [4], Matalliotakis et al [19] and Matorras et al [20], however, did not find a significant difference between the groups in terms of basal PRL levels.…”

Section: Discussionmentioning

confidence: 88%

Hyperprolactinemia and Luteal Insufficiency in Infertile Patients with Mild and Minimal Endometriosis1

Cunha-Filho¹,

Gross²,

Lemos³

et al. 2001

Horm Metab Res

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The objective of the present paper was to assess the presence of hormonal alterations in infertile women with stage I or II endometriosis (Group III, n = 20) compared to fertile women without endometriosis (Group I, n = 14) and to fertile women with endometriosis (Group II, n = 7). Serum levels of FSH, LH, estradiol, TSH, and PRL were measured between days 1 and 5 of the early follicular phase; in the luteal phase, three serum samples were collected for progesterone measurement, and endometrial biopsies were performed. Serum estradiol levels were lower (p = 0.035) in infertile patients with endometriosis than in fertile patients without endometriosis. Six infertile patients with endometriosis presented prolactin levels above 20 ng/ml. This was not observed in the other groups. Luteal insufficiency was more frequent in infertile patients with endometriosis (78.9%) than in fertile patients with (42.9%) or without endometriosis (0%). In a multiple logistic regression analysis, only the presence of endometriosis and infertility was significantly associated with luteal insufficiency. The serum levels of LH, FSH, and TSH were not significantly different among the groups. Luteal insufficiency and altered prolactin secretion were associated with endometriosis, and could be important mechanisms causing infertility in this group of patients.

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Section: Discussionmentioning

confidence: 88%

Hyperprolactinemia and Luteal Insufficiency in Infertile Patients with Mild and Minimal Endometriosis1

Cunha-Filho¹,

Gross²,

Lemos³

et al. 2001

Horm Metab Res

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“…Based on endometrial biopsies and peripheral hormonal measurements, no difference was found between luteal phases of infertile women with and without endometriosis. 45,46 Our group reported that several cytokines such as MCP-1, IL-8, and growthregulated α (Gro-α) that are elevated in the peritoneal fluid of patients with endometriosis are also elevated in the follicular fluid. [47][48][49][50] The concentration of MCP-1 in the follicular fluid increases with advancing stages of endometriosis.…”

Section: Effects Of Inflammatory Mediators Of Endometriosis On Follicmentioning

confidence: 99%

Endometriosis and Inflammation in Infertility

Halis

Arıcı

2004

Annals of the New York Academy of Sciences

142

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A wealth of publications proposes that endometriosis and inflammation may have an unfavorable influence on fertility. A recent meta-analysis of assisted reproductive technologies demonstrated that, once confounding factors are controlled for, the pregnancy rate in women with endometriosis is approximately 50% of the rate of women with tubal factor infertility. Peritoneal fluid of women with endometriosis contains elevated amounts of macrophages and their secreted products, such as growth factors, cytokines, and angiogenic factors. Because reproductive organs are bathed in and thus will be influenced by peritoneal fluid, these proinflammatory mediators would affect various aspects of reproduction in women with endometriosis. Advanced stages of endometriosis may have easily understandable factors, such as distortion of the anatomy, causing infertility. On the other hand, in minimal or mild endometriosis mechanisms underlying reproductive failure are subtle and remain controversial. Recent reports suggest that inflammatory factors play a role in this endometriosis-associated reproductive failure. This review provides an overview of recent data on the effects of endometriosis-associated inflammation on fertility.

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“…One study showed that the 8 am decline in prolactin levels (seen in healthy women) failed to occur in women with endometriosis [20]. However, Brosens et al [21], Matorras et al [22], Arumugam [23] and Matalliotakis et al [24] did not find a significant difference in basal prolactin levels between the groups.…”

Section: Introductionmentioning

confidence: 99%

Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis

Bilibio

Souza

Rodini

et al. 2014

Gynecol Obstet Invest

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Background/Aims: To evaluate serum prolactin and CA-125 levels as biomarkers for the diagnosis of peritoneal endometriosis. Methods: A prospective study was performed. Blood samples were drawn from a peripheral vein during the secretory phase of the menstrual cycle (day 19-21 prior to the surgery) to analyze through relative operating characteristic curve the serum prolactin and CA-125 levels for diagnosis of peritoneal endometriosis. The study wasperformed with 97 participants, 63 women with peritoneal endometriosis and 34 healthy women. Results: The sensitivity and specificity of peritoneal endometriosis diagnosis were equivalent for prolactin (21 and 99%) and for CA-125 (27 and 97%; p = 0.58). These two markers were used in a parallel test utilizing the usual cutoff (prolactin 20.0 ng/ml and CA-125 35 U/I). The sensitivity and specificity were 44 and 99%. However, by utilizing the best cutoff (prolactin 14.8 ng/ml and for CA-125 19.8 U/I), sensitivity, specificity and negative predictive value were 77, 88 and 97%, respectively. Conclusion: Serum CA-125 and prolactin levels assessed together, and considering the cutoff for CA-125 (19.9 U/I) and prolactin (14.8 ng/ml), allow the diagnosis of peritoneal endometriosis with acceptable sensitivity and specificity (77 and 88%) and a high negative predictive value (97%).

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Infertile women with and without endometriosis: A case control study of luteal phase and other infertility conditions

Abstract: Luteal phase defects, sperm abnormalities and myomas are no more common in EAI than in NEI or in advanced stages of endometriosis.

Cited by 18 publications

References 28 publications

Hyperprolactinemia and Luteal Insufficiency in Infertile Patients with Mild and Minimal Endometriosis1

Hyperprolactinemia and Luteal Insufficiency in Infertile Patients with Mild and Minimal Endometriosis1

Endometriosis and Inflammation in Infertility

Serum Prolactin and CA-125 Levels as Biomarkers of Peritoneal Endometriosis

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