Infertility and ART after transplantation

Pinho, Joao Correia De; Sauer, Mark V.

doi:10.1016/j.bpobgyn.2014.07.017

Cited by 14 publications

(9 citation statements)

References 74 publications

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“…Over the last decades, increasing experience of the use of ART has been collected (De Pinho and Sauer 2014; Transplant_Pregnancy_Registry_International 2020). Even though different series with reported good graft, patient and neonatal outcomes have been published (Norrman, Bergh, and Wennerholm 2015; Yaprak et al 2019; Transplant_Pregnancy_Registry_International 2020), significant risks cannot be excluded.…”

Section: Discussionmentioning

confidence: 99%

“…Multiparity has been shown to critically impact morbidity and mortality in transplanted women as well as offspring health (Furman et al 1999). Finally, a twofold increase risk of development of thrombosis has been reported in patients subjected to hormonal treatment for ovarian hyperstimulation (De Pinho and Sauer 2014).…”

Section: Discussionmentioning

confidence: 99%

“…The mechanisms behind this observation have not been studied in detail. As main contributing factors, anovulation and amenorrhea associated with renal and hepatic insufficiency as well as gonadotoxicity have been postulated (Cundy, O'Grady, and Williams 1990; De Pinho and Sauer 2014; Lim et al 1980).…”

Section: Introductionmentioning

confidence: 99%

“…The use of assisted reproductive technology (ART) is progressively being introduced in this patient population (De Pinho and Sauer 2014). Whereas artificial insemination and pharmacological supporting therapy might have only a minor impact on women’s health, the use of in vitro fertilization might increase patient and graft risk, especially when gametes of autologous origin are used, due to risks associated with the oocyte retrieval process, with the presence of ovarian hyperstimulation syndrome (OHSS) and increased risk of thromboembolism (Whelan and Vlahos 2000).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Maternity After Orthotopic Liver Transplantation: Can the Use of Biological Fertility Indicators Help? Our Own Experience and Literature-based Recommendations

et al. 2022

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Over the last 5 decades, the fulfillment of maternity wishes in solid organ transplanted women has become a reality. Despite pregnancy contraindication in transplanted women during the early post-transplant period, such a condition can be overcome after 12 months if patients show a good clinical evolution and do not present other general pre-conceptional findings. This article presents the case report of a young female liver transplanted patient that used symptothermal method as a reliable family planning method. After her gestational contraindication was lifted, observation of biological fertility indicators and fertility-guided sexual intercourse helped her fulfill her maternity wish and conceive and carry out a healthy offspring. Based on this case and on the available bibliographic evidence, this paper reviews the potential implications of the use of this kind of approach as a safe and effective alternative to assisted reproduction technology in the management of potential infertility problems in the young female transplanted population, a population which according to literature has higher rates of unsuccessful parenthood and might also be more vulnerable to iatrogenicity of ovarian hyperstimulation process and to multiple pregnancy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternity After Orthotopic Liver Transplantation: Can the Use of Biological Fertility Indicators Help? Our Own Experience and Literature-based Recommendations

et al. 2022

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“…With lung transplantation techniques and clinical outcomes continually improving, adults with CF may want to explore opportunities to create families post‐transplantation, given their ‘second lease on life.’ However, this group does not receive information about FP as a reproductive option before undergoing transplantation (Ladores et al, 2018). Immunosuppressive therapy post‐transplantation may be gonadotoxic and teratogenic, subsequently, rendering the use of fresh sperm or eggs post‐transplantation inadvisable (DeFilippis et al, 2020; DePinho & Sauer, 2014; Hirschfield‐Cytron et al, 2011). A recent case report highlighted one couple's devastation on learning that they missed an opportunity to have biological children because of a lack of FP counselling provided by their CF care team pre‐lung transplantation (Ladores et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Fertility preservation in women with cystic fibrosis pre‐lung transplantation: A mixed methods study

Ladores

Campbell

Bray

et al. 2021

Journal of Advanced Nursing

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Aims Explore the knowledge, experiences, preferences, and concerns related to fertility preservation as an option for building a biological family among women with cystic fibrosis. Design Convergent mixed methods study design. Methods We recruited women with cystic fibrosis of childbearing age in the United States through cystic fibrosis centres, snowball sampling, and social media. Participants completed an anonymous survey about fertility and fertility preservation (n = 50). We also conducted audio‐recorded, semi‐structured interviews with a subset of women to gain a better understanding of their perspectives (n = 20). We transcribed the interviews verbatim and analysed them using thematic analysis. Results For the quantitative arm, 78% of women indicated that they would like to have a child in the future; however, 74% reported never having had conversations about fertility preservation with their providers. For the qualitative arm, four major themes emerged: (1) Women with cystic fibrosis have inadequate knowledge about fertility and fertility preservation; (2) fertility is a low priority area for the cystic fibrosis care team; (3) women with cystic fibrosis recommend that the cystic fibrosis care team provide specific fertility resources; and (4) providers and literature lack information on fertility and cystic fibrosis. Integrated findings identified that while the majority of women with cystic fibrosis want to become mothers in the future, including post‐lung transplantation, they have not received education on fertility preservation, and there is a general lack of knowledge on the topic of fertility in cystic fibrosis. Conclusion Women with cystic fibrosis desire to have children but have little knowledge about fertility preservation, and cystic fibrosis providers do not initiate family planning discussions. Impact Findings from the study support that additional education is needed for women with cystic fibrosis who are considering parenthood. Clinical care models should include early, regular, and thoughtful discussions about reproductive health issues, including fertility preservation.

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Counselling, Research Gaps, and Ethical Considerations Surrounding Pregnancy in Solid Organ Transplant Recipients

Sawinski

Ralston

Coscia³

et al. 2022

Bioethical Inquiry

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Infertility and ART after transplantation

Cited by 14 publications

References 74 publications

Maternity After Orthotopic Liver Transplantation: Can the Use of Biological Fertility Indicators Help? Our Own Experience and Literature-based Recommendations

Maternity After Orthotopic Liver Transplantation: Can the Use of Biological Fertility Indicators Help? Our Own Experience and Literature-based Recommendations

Fertility preservation in women with cystic fibrosis pre‐lung transplantation: A mixed methods study

Counselling, Research Gaps, and Ethical Considerations Surrounding Pregnancy in Solid Organ Transplant Recipients

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