Infertility Due to Bilateral Ovarian Hypoplasia in Sheep Homozygous (FecX1 FecX1) for the Inverdale Prolificacy Gene Located on the X Chromosome

Davis, G. H.; McEwan, J. C.; Fennessy, P. F.; Dodds, K. G.; McNatty, Kenneth P.; Wai‐Sum, O

doi:10.1095/biolreprod46.4.636

Cited by 107 publications

(78 citation statements)

References 9 publications

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“…The lack of normal ovarian follicular development also affects the development of the uterus. Adult ewes have a reproductive tract with morphology similar to that observed in a young lamb (Davis et al 1992, Nicol et al 2009). Analysis of the uterus of homozygous Inverdale animals showed suppression of uterine development (Hayashi et al 2008).…”

Section: Mechanisms Of Action Of Gdf9 and Bmp15 And The Involvement Omentioning

confidence: 83%

Using sheep lines with mutations in single genes to better understand ovarian function

Juengel¹,

Davis²,

McNatty³

2013

Reproduction

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Livestock populations have been subjected to strong selection pressure to improve reproductive success, and this has led to the identification of lines of animals with increased fecundity. These animals provide a rich biological resource for discovery of genes and regulatory mechanisms that underpin improved reproductive success. To date, three genes, all related to the transforming growth factor b pathway, have been identified as having mutations that lead to alterations in ovulation in sheep. In addition, several other sheep lines have been identified with putative mutations in single genes with major effects on ovulation rate. This review is focused on the identification of the mutations affecting ovulation rate and how these discoveries have provided new insights into control of ovarian function.Reproduction (2013) 146 R111-R123

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Section: Mechanisms Of Action Of Gdf9 and Bmp15 And The Involvement Omentioning

confidence: 83%

Using sheep lines with mutations in single genes to better understand ovarian function

Juengel¹,

Davis²,

McNatty³

2013

Reproduction

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“…The mean ovarian volume in adult II ewes is about 77% less than that for the IC or CC genotypes (Smith et al 1997). Moreover, uteri of 1.5-year-old II ewes are much smaller than those for CC ewes (Davis et al 1992). However, the circulating levels of FSH and LH are not different between the CC and IC genotypes in either fetal or adult ewes.…”

Section: Introductionmentioning

confidence: 82%

“…In the wild-type ewes, the first wave of ovarian follicle growth occurs in the fetus between days 100 and 120 of gestation . However, homozygous (II) ewes are infertile and incapable of normal ovarian follicular development beyond the primary (type 2) stage (Braw-Tal et al 1993b, Smith et al 1997, resulting in a 'streak' ovary phenotype (Davis et al 1992, Galloway et al 2002.…”

Section: Introductionmentioning

confidence: 99%

Postnatal uterine development in Inverdale ewe lambs

Hayashi

O’Connell²,

Juengel³

et al. 2008

Reproduction

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Postnatal development of the uterus involves, particularly, development of uterine glands. Studies with ovariectomized ewe lambs demonstrated a role for ovaries in uterine growth and endometrial gland development between postnatal days (PNDs) 14 and 56. The uterotrophic ovarian factor(s) is presumably derived from the large numbers of growing follicles in the neonatal ovary present after PND 14. The Inverdale gene mutation (FecXI) results in an increased ovulation rate in heterozygous ewes; however, homozygous ewes (II) are infertile and have 'streak' ovaries that lack normal developing of preantral and antral follicles. Uteri were obtained on PND 56 to determine whether postnatal uterine development differs between wild-type (CC) and II Inverdale ewes. When compared with wild-type ewes, uterine weight of II ewes was 52% lower, and uterine horn length tended to be shorter, resulting in a 68% reduction in uterine weight:length ratio in II ewes. Histomorphometrical analyses determined that endometria and myometria of II ewes were thinner and intercaruncular endometrium contained 38% fewer endometrial glands. Concentrations of estradiol in the neonatal ewes were low and not different between CC and II ewes, but II ewes had lower concentrations of testosterone and inhibin-a between PNDs 14 and 56. Receptors for androgen and activin were detected in the neonatal uteri of both CC and II ewes. These results support the concept that developing preantral and/or antral follicles of the ovary secrete uterotrophic factors, perhaps testosterone or inhibin-a, that acts in an endocrine manner to stimulate uterine growth and endometrial gland development in the neonatal ewes. Reproduction (2008) 135 357-365

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“…The Inverdale mutation is characterized by a single change of nucleotides resulting in different aminoacids (V31N) (Liao et al, 2003) (Davis et al, 1992).…”

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confidence: 99%

Survey of mutations in prolificacy genes in Santa Ines and Morada Nova sheep

Holanda¹,

Oliveira

Silva

et al. 2017

Arq. Bras. Med. Vet. Zootec.

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Polymorphisms in the BMP-15 gene related to Galway (FecX G ) and Inverdale (FecX I ) and in the BMPR-1B gene known as Booroola (FecB) mutations were investigated using the Polymerase Chain Reaction -Restriction Fragment Length Polymorphism (PCR-RFLP) method, on sheep from the breeds Santa Inês (n= 574) and Morada Nova (n=282). DNA was extracted and amplified through PCR with specific primers that introduced a restriction site in association with the mutation. The PCR products were submitted to endonucleases. The experiment found no FecX G and FecX I mutations. Six samples of animals with multiple offspring/birth history presented polymorphism for FecB similar to control samples, but this pattern was not confirmed by nucleotide sequencing. Although the absence of these mutations in the studied breeds, other factors related to prolificacy should be investigated to explain the inherent prolificity mechanisms.

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Infertility Due to Bilateral Ovarian Hypoplasia in Sheep Homozygous (FecX1 FecX1) for the Inverdale Prolificacy Gene Located on the X Chromosome

Cited by 107 publications

References 9 publications

Using sheep lines with mutations in single genes to better understand ovarian function

Using sheep lines with mutations in single genes to better understand ovarian function

Postnatal uterine development in Inverdale ewe lambs

Survey of mutations in prolificacy genes in Santa Ines and Morada Nova sheep

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