Infertility in Male Pesticide Workers

Whorton, Donald; Krauss, R.M.; Marshall, Sumner; Milby, ThomasH.

doi:10.1016/s0140-6736(77)92665-4

Cited by 586 publications

(159 citation statements)

References 4 publications

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“…Moreover, sad experience from the occupational arena clearly documents that also human spermatogenesis may be vulnerable to chemicals at very low exposure levels not causing intoxication. The dibromochloropropane (DBCP) tragedy that was disclosed in 1977 in California [5] and the subsequent year in Israel [6] was a strong impetus for intensified research into environmental hazards to male reproductive health [7] (Figure 2). …”

Section: Introductionmentioning

confidence: 99%

Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

108

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Male reproductive disorders that are of interest from an environmental point of view include sexual dysfunction, infertility, cryptorchidism, hypospadias and testicular cancer. Several reports suggest declining sperm counts and increase of these reproductive disorders in some areas during some time periods past 50 years. Except for testicular cancer this evidence is circumstantial and needs cautious interpretation. However, the male germ line is one of the most sensitive tissues to the damaging effects of ionizing radiation, radiant heat and a number of known toxicants. So far occupational hazards are the best documented risk factors for impaired male reproductive function and include physical exposures (radiant heat, ionizing radiation, high frequency electromagnetic radiation), chemical exposures (some solvents as carbon disulfide and ethylene glycol ethers, some pesticides as dibromochloropropane, ethylendibromide and DDT/DDE, some heavy metals as inorganic lead and mercury) and work processes such as metal welding. Improved working conditions in affluent countries have dramatically decreased known hazardous workplace exposures, but millions of workers in less affluent countries are at risk from reproductive toxicants. New data show that environmental low-level exposure to biopersistent pollutants in the diet may pose a risk to people in all parts of the world. For other toxicants the evidence is only suggestive and further evaluation is needed before conclusions can be drawn. Whether compounds as phthalates, bisphenol A and boron that are present in a large number of industrial and consumer products entails a risk remains to be established. The same applies to psychosocial stressors and use of mobile phones. Finally, there are data indicating a particular vulnerability of the fetal testis to toxicants-for instance maternal tobacco smoking. Time has come where male reproductive toxicity should be addressed form entirely new angles including exposures very early in life.

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Section: Introductionmentioning

confidence: 99%

Male reproductive organs are at risk from environmental hazards

Bonde¹

2009

Asian J Androl

108

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“…There is a general reluctance of individuals to participate in such studies; sperm samples are not as willingly donated as blood samples, and subjects may be reticent to discuss their sexual performance. However, one of the best publicized male reproductive toxicants in man, the nematocide and soil fumigant dibromochloropropane (DBCP), has long been known to produce testicular atrophy in rats (58) at doses broadly equivalent to those subsequently found to be toxic to humans (61). In addition to rats and man, it is also an effective testicular toxicant in guinea pigs, hamsters, mice, and rabbits.…”

Section: Introductionmentioning

confidence: 99%

Review Article: Evaluation of Testicular Toxicity in Safety Evaluation Studies: The Appropriate Use of Spermatogenic Staging

1997

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“…22 Slutsky et al in his report which represents the largest cohort of DBCP(Dibromochloroprppane) exposed workers, found that after a median exposure of three years, 64.3% of these men overall, and 90.1% of men studied from the Philippines, had oligospermia or azoospermia . 23 The study by Whorton et al (1977), Potashniket al (1978), Lipshultz et al (1980) and Egnatz et al (1980) had the same results of a significant association between exposure to pesticides and semen quality . 24,25,26,27 .…”

Section: Discussionmentioning

confidence: 75%

“…23 The study by Whorton et al (1977), Potashniket al (1978), Lipshultz et al (1980) and Egnatz et al (1980) had the same results of a significant association between exposure to pesticides and semen quality . 24,25,26,27 . Some of the studies are not in association with our study.…”

Section: Discussionmentioning

confidence: 75%

Hazardous effect of Agricultural occupation on male fertility in central India.

Jiwane

2013

Int Jour of Biomed Res

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Infertility in Male Pesticide Workers

Cited by 586 publications

References 4 publications

Male reproductive organs are at risk from environmental hazards

Male reproductive organs are at risk from environmental hazards

Review Article: Evaluation of Testicular Toxicity in Safety Evaluation Studies: The Appropriate Use of Spermatogenic Staging

Hazardous effect of Agricultural occupation on male fertility in central India.

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