Infertility in Mice Caused by Fasting at About the Time of Mating

McClure, T. J.

doi:10.1530/jrf.0.0130393

Cited by 23 publications

(16 citation statements)

References 16 publications

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“…While this practice is likely to assist in maintaining normal blood-glucose concentrations (McClure 1977), there is little published information on the glucose concentrations of dairy cattle in this country and therefore little information is available on which to base estimates of the occurrence of hypoglycaemia. Studies on mice treated with the glucose metabolic inhibitor 2 deoxy-D-glucose and on cows treated with protamine zinc-insulin suggest that hypoglycaemia can be a primary cause of infertility in animals fed carbohydrate-deficient diets (McClure 1967(McClure , 1968.…”

Section: Introductionmentioning

confidence: 99%

Observations of the First Service Non‐return Rates of the Hypoglycaemic, Concentrate‐fed Dairy Herds

McClure

Payne

1978

Aust Veterinary J

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Fourteen dairy herds which had been subjected to the Compton Metabolic Profile test on a total of 29 occasions were selected from the records of the institute for Research on Animal Diseases, United Kingdom, because they had a wide range of mean blood-glucose concentrations. Two herds had to be rejected from the study because of inadequate breeding records, leaving 12 herds (26 profile tests) to be included. The first service non-return rate of each herd was calculated from the breeding records of 10 cows mated closest to the date of each profile test. These rates were positively related to the mean blood-glucose concentrations of the lactating cows (P less than 0.01).

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Section: Introductionmentioning

confidence: 99%

Observations of the First Service Non‐return Rates of the Hypoglycaemic, Concentrate‐fed Dairy Herds

McClure

Payne

1978

Aust Veterinary J

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“…Thus fasting probably activates an inhibitory opioid pathway within the brain to inhibit LH secretion. INTRODUCTION In the females of many mammalian species, chronic malnutrition is known to impair reproductive capacity (Marrian & Parkes, 1929;Allen & Lamming, 1961;McClure, 1967). The aetiology of this effect is not well understood.…”

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confidence: 99%

Fasting impairs LH secretion in female rats by activating an inhibitory opioid pathway

Dyer¹,

Mansfield²,

Corbet³

et al. 1985

Journal of Endocrinology

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Two experiments were undertaken to investigate the way that fasting impairs LH secretion and to assess whether endogenous opioid mechanisms might be responsible for the impairment. In the first experiment, pulsatile LH secretion was measured in a total of 51 chronically ovariectomized female rats. Initially 29 rats were subjected to food withdrawal for 24, 48, 72 or 120 h before the experiment. When compared with data collected from eight unfasted control rats, the 120-h fast was found to reduce significantly the mean peak and trough values of the LH pulses measured. However, in a subsequent study, the inhibition of pulsatile LH secretion by a 120-h fast was prevented in a group of eight rats given the opioid antagonist naloxone hydrochloride before the start of the blood-sampling period. Naloxone was without effect on pulsatile LH secretion in eight unfasted control rats. In the second experiment, plasma LH concentrations were measured before and after unilateral electrical stimulation of the ventral noradrenergic tract (VNAT) in ovariectomized female rats pretreated with oestradiol benzoate. In 17 rats VNAT stimulation caused a significant rise in plasma LH, but after a 72-h fast this rise was significantly less than in unfasted control rats. However, pretreatment of fasted rats with naloxone (n = 9) significantly enhanced the VNAT-stimulated release of LH to the control values. Naloxone did not potentiate VNAT-stimulated LH release in unfasted animals (n = 6) or LH release in control unstimulated rats (n = 12). The experiments indicate that both pulsatile LH secretion, and LH release caused by VNAT stimulation, are impaired by an acute fast.(ABSTRACT TRUNCATED AT 250 WORDS)

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“…It is well established that food deprivation during the preimplantation period induces implantation failure in newly inseminated female mice (McClure, 1959(McClure, , 1962Bruce, 1963;Sahu and Dominic, 1985). The presence of the stud male effectively prevents the implantation failure in food-deprived females (Archunan and Dominic, 1989).…”

Section: Introductionmentioning

confidence: 99%

Stud Male Protection of Implantation in Food-deprived Mice: Evaluation of the Involvement of Olfactory-vomeronasal Systems

Archunan

Dominic²

2009

Exp Clin Endocrinol Diabetes

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The protection of implantation in food-deprived females provided by exposure to the stud males was not abolished following surgical ablation of the vomeronasal organ (VNO) from females. By contrast, stud males failed to protect implantation in food-deprived females made peripherally anosmic by intranasal irrigation with ZnSO4. The results suggest that the main olfactory system, and not the accessory olfactory system, is involved in the perception of the stud male-originating olfactory cue that protects implantation in nutritionally-stressed females. The findings also provide circumstantial evidence that the study male-originating olfactory cue involved in the protective effect is volatile (air-borne).

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Infertility in Mice Caused by Fasting at About the Time of Mating

Cited by 23 publications

References 16 publications

Observations of the First Service Non‐return Rates of the Hypoglycaemic, Concentrate‐fed Dairy Herds

Observations of the First Service Non‐return Rates of the Hypoglycaemic, Concentrate‐fed Dairy Herds

Fasting impairs LH secretion in female rats by activating an inhibitory opioid pathway

Stud Male Protection of Implantation in Food-deprived Mice: Evaluation of the Involvement of Olfactory-vomeronasal Systems

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