Background: All women are at risk for breast and gynecologic cancer. There is no doubt that breast and gynecologic cancer is a stressful experience by creating heavy psychological trauma for the woman and has great impact on psychological and emotional health of women. Depression and anxiety consider the emotional disturbances which usually associated with cancer. Aim: assess prevalence rate and investigate the emotional effects of gynecologic and breast cancer. Subjects and Methods: For this study, data were collected through in-depth interviews for the convenience of 200 cancers diagnosed female who were admitted in inpatient wards and/or attending to outpatient gynecological and surgery clinics at University Hospital and General Hospital in Beni-Suef city. Results: The findings of this study indicated that, all types of gynecologic and breast cancer women suffered from different degrees of anxiety and depression. Breast, ovarian, cervical, vulval cancers have significant relations with symptoms of depression scale score. Emotional distress symptoms were severe in women aged 30-40 years, the secondary education level. Depression and anxiety symptoms were more observable in housewives, urbanized, nuclear and not crowded families, compared with working, rural, extended and crowded ones. A statistically significant impact of pain related menstruation, surgical intervention and its type and symptoms of depression scale score. Conclusion: Based on the findings of the present study, it can be concluded that, there is a statistically significant association between cancer women and emotional distress symptoms.