Infertility Treatment in Patients with Polycystic Ovary Syndrome (PCOS)

Tomić, Vlatka; Tomić, Jozo

doi:10.4172/2165-7491.1000e113

Cited by 4 publications

(2 citation statements)

References 27 publications

(12 reference statements)

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“…The familial incidence of this syndrome has been well established and its prevalence and symptoms vary in different ethnicities ( Allahbadia & Merchant, 2011 ). The main cause of this syndrome is unknown, but there is evidence of several genes involved, which work in appropriate environmental circumstances, especially nutritional factors ( V. Tomic & J. Tomic, 2012 ). Some studies show evidence of dominant x-linked inheritance ( Badawy & Elnashar, 2011 ).…”

Section: Introductionmentioning

confidence: 99%

Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women

Sedighi¹,

Akbari²,

Afrakhteh³

et al. 2014

GJHS

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Given the high prevalence of polycystic ovary syndrome (PCOS), and that a lifestyle is recognized effective in development of many diseases, this study aimed to compare lifestyle of women with PCOS and healthy women. Nor are there sufficient studies on the difference between lifestyle of these people with that of healthy people. Furthermore, studies show that changes in lifestyle improve this disease. This descriptive-comparative study was conducted on 65 women with PCOS and 65 healthy women of 18 to 45 years old who presented to hospitals affiliated to Shahid Beheshti University of Medical Sciences in 2013. The subjects were selected using multi stage random sampling method. The data were collected using questionnaires for diet, International Physical Activity Questionnaire, and unhealthy behaviors and were analyzed in SPSS v. 17, using descriptive statistics, Man-Whitney, independent t, Chi-square and logistic regression tests. The results showed there was a significant relationship between PCOS and inappropriate diet (p=0.009), low physical activity (p=0.009), but no relationship was observed between PCOS and unhealthy behaviors. Given the results obtained, training and awareness raising is necessary for women and girls especially about appropriate diet and regular physical activity.

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Section: Introductionmentioning

confidence: 99%

Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women

Sedighi¹,

Akbari²,

Afrakhteh³

et al. 2014

GJHS

View full text Add to dashboard Cite

show abstract

“…Metformin in combination with CC may increase the rate of ovulation and pregnancy, but does not significantly improve the rate of live births over that of the CC alone. Metformin can be also added to CC in women who show resistance to clomiphene, who are older and/or have visceral obesity 12 . However, the role of metformin in the treatment of infertility in women with polycystic ovary syndrome (PCOS) is still controversial 13 .Early systematic reviews of randomized controlled trials (RCTs) showed that metformin was more effective than placebo for inducing ovulation, however, these trials and systematic reviews were vastly underpowered to detect differences in clinically relevant outcomes such as pregnancy and live birth 14 .…”

Section: Introductionmentioning

confidence: 99%

Comparsion Between the Efficacy of Metformin Plus Clomiphene and Clomiphene Alone in the Treatment of Primary Infertility Due to Polycystic Ovarian Syndrome in Obese Women

Sadiq¹,

Ghafoor²,

Sara³

2022

PJMHS

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Background: Infertility is defined as the inability to conceive after one to two years of unprotected intercourse. It is of two types primary infertility and secondary infertility Polycystic ovary syndrome (PCOS) is one of the most common endocrinopathies affecting 5%–10% of reproductive age women. To compare the efficacy of metformin plus clomiphene and clomiphene alone in the treatment of primary infertility due to polycystic ovary syndrome in obese women Materials And Methods: It was Randomized Controlled Trial, which was conducted in the department of Obstetrics and Gynaecology, Hospital, Peshawar, between 30th May 2019 to 8th January 2022) Sample size will be 380 in each group using P 1 = 15%, P 2 = 22% and power of 80% and 95% confidence interval under WHO Software for sample size determination. Results: A total of 380 patients in each group were observed. Average age of the patients was 26.60 years+ 3.99SD with range of 19-35 years. Group A showed 88(23.2%) efficacies. Similarly Group B showed 68 (17.9%) efficacies. Efficacy was significant in both the groups with p-value=0.044. Conclusion: Metformin plus clomiphene is more efficacious than clomiphene alone in the treatment of primary infertility due to polycystic ovary syndrome in obese women. Keywords: Efficacy, metformin, clomiphene, polycystic ovary syndrome, primary infertility

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Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

Carbone¹,

Davis²,

Fei³

et al. 2019

Sci Rep

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Polycystic ovary syndrome (PCOS) is a major reproductive disorder that is responsible for 80% of anovulatory infertility and that is associated with hyperandrogenemia, increased risk of obesity, and white adipose tissue (WAT) dysfunction. We have previously demonstrated that the combination of chronic testosterone (T) treatment and an obesogenic Western-style diet (WSD) exerts synergistic functional effects on WAT, leading to increased lipid accumulation in visceral adipocytes by an unknown mechanism. In this study, we examined the whole-genome transcriptional response in visceral WAT to T and WSD, alone and in combination. We observed a synergistic effect of T and WSD on gene expression, resulting in upregulation of lipid storage genes concomitant with adipocyte hypertrophy. Because DNA methylation is known to be associated with body fat distribution and the etiology of PCOS, we conducted whole-genome DNA methylation analysis of visceral WAT. While only a fraction of differentially expressed genes also exhibited differential DNA methylation, in silico analysis showed that differentially methylated regions were enriched in transcription factor binding motifs, suggesting a potential gene regulatory role for these regions. In summary, this study demonstrates that hyperandrogenemia alone does not induce global transcriptional and epigenetic response in young female macaques unless combined with an obesogenic diet.

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Infertility Treatment in Patients with Polycystic Ovary Syndrome (PCOS)

Cited by 4 publications

References 27 publications

Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women

Comparison of Lifestyle in Women With Polycystic Ovary Syndrome and Healthy Women

Comparsion Between the Efficacy of Metformin Plus Clomiphene and Clomiphene Alone in the Treatment of Primary Infertility Due to Polycystic Ovarian Syndrome in Obese Women

Synergistic Effects of Hyperandrogenemia and Obesogenic Western-style Diet on Transcription and DNA Methylation in Visceral Adipose Tissue of Nonhuman Primates

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