Infertility treatment strategy involving combined freeze‐all embryos and single vitrified‐warmed embryo transfer during hormonal replacement cycle for <i>in vitro</i> fertilization of women with hypogonadotropic hypogonadism

Kuroda, Keiji; Ezoe, Kenji; Kato, Keiichi; Yabuuchi, Akiko; Segawa, Tomoya; Kobayashi, Tamotsu; Ochiai, Asako; Katoh, Noriko; Takeda, Satoru

doi:10.1111/jog.13597

Cited by 11 publications

(4 citation statements)

References 28 publications

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“…Kuroda et al. ( 21 ) reported good clinical pregnancy and live birth rates (65.1% and 50.5%) after FET in patients with HH; however, they did not compare these outcomes with a control population or with fresh embryo transfer cycle outcomes. Our results suggest that patients with HH have lower pregnancy rates with FET than those with fresh transfer when controlling for confounders and those with PCOS or tubal factor infertility.…”

Section: Discussionmentioning

confidence: 99%

In vitro fertilization cycle and embryo transfer outcomes in oligoanovulatory patients with hypothalamic hypogonadism vs. polycystic ovary syndrome and compared with normo-ovulatory patients

et al. 2022

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Section: Discussionmentioning

confidence: 99%

In vitro fertilization cycle and embryo transfer outcomes in oligoanovulatory patients with hypothalamic hypogonadism vs. polycystic ovary syndrome and compared with normo-ovulatory patients

et al. 2022

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“…One retrospective study showed similar cumulative pregnancy and live birth rates after single and double frozen-thawed blastocyst transfers after a freezeonly strategy, 20 and another study evaluating the freeze-only strategy and SET in women with hypogonadotropic hypogonadism showed that SET is an effective strategy for decreasing the incidence of multiple conceptions while maintaining satisfactory live birth rates (50.5%). 21 Corroborating our hypothesis of better clinical outcomes after a freeze-only strategy plus SET, the American Society for Reproductive Medicine and the Society for Assisted Reproductive Technology (ASRM/SART) recommended SET for patients with a good prognosis aged < 38 years, except in cases in which the patient had several previous cycle failures and for whom DET was suggested. 5 Reinforcing the efficiency of the ASRM/SART recommendation, Eubanks et al 22 evaluated retrospective data about clinical PRs before and after the ASRM/SART guidelines were published in 2017, as their clinic policy is to transfer no more than the recommended number of embryos.…”

Section: Discussionmentioning

confidence: 99%

“…One retrospective study showed similar cumulative pregnancy and live birth rates after single and double frozen-thawed blastocyst transfers after a freeze-only strategy, 20 and another study evaluating the freeze-only strategy and SET in women with hypogonadotropic hypogonadism showed that SET is an effective strategy for decreasing the incidence of multiple conceptions while maintaining satisfactory live birth rates (50.5%). 21 …”

Section: Discussionmentioning

confidence: 99%

One Plus One is Better than Two: An Approach Towards a Single Blastocyst Transfer Policy for All IVF Patients

Peregrino

Bonetti

Gomes

et al. 2022

Rev Bras Ginecol Obstet

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Objective It is known that the single embryo transfer (SET) is the best choice to reduce multiples and associated risks. The practice of cryopreserving all embryos for posterior transfer has been increasingly performed for in vitro fertilization (IVF) patients at the risk of ovarian hyperstimulation syndrome or preimplantation genetic testing for aneuploidy. However, its widespread practice is still controverse. The aim of this study was to evaluate how effective is the transfer of two sequential SET procedures compared with a double embryo transfer (DET) in freeze-only cycles. Methods This retrospective study reviewed 5,156 IVF cycles performed between 2011 and 2019, and 506 cycles using own oocytes and freeze-only policy with subsequent elective frozen-thawed embryo transfers (eFET) were selected for this study. Cycles having elective SET (eSET, n = 209) comprised our study group and as control group we included cycles performed with elective DET (eDET, n = 291). In the eSET group, 57 couples who had failed in the 1st eSET had a 2nd eFET, and the estimated cumulative ongoing pregnancy rate was calculated and compared with eDET. Results After the 1st eFET, the ongoing pregnancy rates were similar between groups (eSET: 35.4% versus eDET: 38.5%; p = 0.497), but the estimated cumulative ongoing pregnancy rate after a 2nd eFET in the eSET group (eSET + SET) was significantly higher (48.8%) than in the eDET group (p < 0.001). Additionally, the eSET + SET group had a 2.7% rate of multiple gestations, which is significantly lower than the eDET group, with a 30.4% rate (p < 0.001). Conclusion Our study showed the association of freeze-only strategy with until up to two consecutive frozen-thawed eSETs resulted in higher success rates than a frozen-thawed DET, while drastically reducing the rate of multiple pregnancies.

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“…Moreover, eight were fresh, and two were frozen-thawed ET cycles, and one was a combination of both. Recently, Kuroda et al reported that a combination of freeze-all embryo and single vitrified-warmed ET with a hormone replacement cycle for HH, including IHH, had good cumulative pregnancy rates of 73.4% in up to 3 ET cycles 30) . Seven retrospective cohort studies comparing IHH with tubal or male infertility and other causes of poor ovarian responsiveness to gonadotropins have been reported 23 - 27 , 29 , 31) .…”

Section: Discussionmentioning

confidence: 99%

Successful pregnancy and delivery after a vitrified-warmed embryo transfer in a woman with Kallmann syndrome: A case report and literature review

Shiraiwa

Takahashi

Okoshi

et al. 2022

FJMS

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Kallmann syndrome, a congenital disorder of idiopathic hypogonadotropic hypogonadism associated with anosmia, results in infertility because of anovulation. Assisted reproductive technology (ART) is considered when optimal ovulation induction therapy is difficult or when several cycles of ovulation induction therapy do not result in pregnancy. However, evidence is lacking regarding the optimal ART treatment for Kallmann syndrome. We report the case of a 33-year-old woman who successfully achieved pregnancy and delivery after ART treatment. At 29 years old, she was diagnosed with Kallmann syndrome due to hypothalamic amenorrhea and anosmia. At 33 years old, she revisited the hospital, desiring a child after one year of infertility. Due to anovulation, she was treated with gonadotropin therapy, but controlling follicular development was difficult, and thus ART treatment was initiated. The controlled ovarian stimulation (COS) protocol for ART treatment employed gonadotropins, recombinant follicular stimulating hormone/human menopausal gonadotropin plus human chorionic gonadotropin, to promote follicular growth. Four oocytes were retrieved, and two cleaved embryos were vitrified and cryopreserved. After vitrified-warmed embryo transfer of a morula stage embryo in a hormone replacement cycle, pregnancy was achieved but resulted in a miscarriage. A second oocyte retrieval was performed under the same COS; four oocytes were retrieved, and two cleaved embryos were vitrified and cryopreserved. Further, a pregnancy was achieved through the vitrified warmed embryo transfer. At 40 weeks and 6 days of gestation, a baby boy weighing 3,344 g with an Apgar score of 7/8 was delivered vaginally. The mother’s postpartum course and neonate were free from adverse events. For women with Kallmann syndrome, ART treatment and selective embryo cryopreservation may be a reasonable and safe option.

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Infertility treatment strategy involving combined freeze‐all embryos and single vitrified‐warmed embryo transfer during hormonal replacement cycle for in vitro fertilization of women with hypogonadotropic hypogonadism

Abstract: Our results demonstrated that IVF followed by single vitrified-warmed ET in adjusted endocrine milieu during the HR cycle is an effective fertility treatment for women with HH and decreases the incidence of complications, including multiple conceptions.

Cited by 11 publications

References 28 publications

In vitro fertilization cycle and embryo transfer outcomes in oligoanovulatory patients with hypothalamic hypogonadism vs. polycystic ovary syndrome and compared with normo-ovulatory patients

In vitro fertilization cycle and embryo transfer outcomes in oligoanovulatory patients with hypothalamic hypogonadism vs. polycystic ovary syndrome and compared with normo-ovulatory patients

One Plus One is Better than Two: An Approach Towards a Single Blastocyst Transfer Policy for All IVF Patients

Successful pregnancy and delivery after a vitrified-warmed embryo transfer in a woman with Kallmann syndrome: A case report and literature review

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