Infiltrating duct carcinoma within a fibroadenoma

Iyengar, KR; Peh, S. C.; Ch, Yip; Vijayananthan, A.

doi:10.4103/0019-509x.52964

Cited by 11 publications

(8 citation statements)

References 2 publications

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“…Therefore, histological diagnosis is typically unexpected (1,8,9,13,14). The mean age of patients with carcinoma in FA has been reported as 42-44 years, ~20 years subsequent to the peak age of occurrence of FA (15,16).…”

Section: Discussionmentioning

confidence: 99%

“…Malignant transformation within FA is unusual, reported to be 0.1-0.3% in a screened population. However, the number of real cases appears to be even rarer; histological diagnosis is typically unexpected following excision of a breast lesion, with only >100 cases reported in the literature thus far (8,9). Classic lobular carcinoma in situ (LCIS) is a type of lobular neoplasia and is diagnosed when >50% of the acini of a lobular unit are distended and distorted by a dyshesive proliferation of cells with small, and uniform nuclei (10).…”

Section: Introductionmentioning

confidence: 99%

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Fibroadenoma with an unexpected lobular carcinoma in situ: A case report and review of the literature

Bai

Jiang

et al. 2015

Oncology Letters

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Abstract. Fibroadenoma (FA) is the most common type of breast lesion in young female individuals. Although malignant transformation in FA is rare, there is evidence of an association with breast carcinoma, particularly in middle-aged females with associated risk factors, such as a strong family history and/or BRCA-1/2 mutations. The current study presents the case of a 44-year-old female exhibiting lobular carcinoma in situ (LCIS) arising within an FA. Over the previous 20 years, numerous lumps were detected in the patient's breasts, all of which were clinically diagnosed as FA and expectantly managed. One year prior to presentation, the patient's father was diagnosed with esophageal cancer, older sister with kidney cancer and the patient herself with a benign ovarian teratoma. The patient presented with one lump in each breast and monitoring was performed using ultrasonography (US). US detected an increase in the size of the two lumps and analysis of the images was used to propose a diagnosis of FA. Therefore, a lumpectomy was performed. Analysis of the frozen section indicated a diagnosis of FA in the right breast, however, a 5-mm LCIS was identified within the FA of the left breast. Subsequent to the identification of three additional lumps in the left breast, a left mastectomy was performed. During a five-year follow-up period, no local recurrence or contralateral breast carcinoma occurred. The present study showed that FAs containing foci of carcinoma in situ can be indistinguishable from benign lesions following imaging, therefore, despite the incidence of carcinoma within FA is estimated at 0.1-0.3%, it should be considered a long-term risk factor for invasive breast cancer. The present describes a case of LCIS arising within an FA and conducts a review of the relevant literature.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Fibroadenoma with an unexpected lobular carcinoma in situ: A case report and review of the literature

Bai

Jiang

et al. 2015

Oncology Letters

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“…Lobular or ductal invasive or noninvasive cancer can be observed together with fibroadenoma. Although around two-third of these cancers are lobular and one-third is ductal or mixed, the rates of lobular and ductal carcinoma in situ are equal (2,6). In this study, it was identified that invasive ductal carcinoma developed from fibroadenoma epithelial components.…”

Section: Discussionmentioning

confidence: 84%

“…In addition to developing within the fibroadenomas, invasive carcinoma can hold onto the fibroadenomas itself by originating from the neighboring breast tissue. The literature reports that the epithelial component can develop into a carcinoma in situ and invasive cancer (3)(4)(5)(6). Manukyan et al (7) have reported a case of ductal carcinoma in situ that has developed within fibroadenomas itself.…”

Section: Introductionmentioning

confidence: 99%

Invasive Ductal Carcinoma Developing From Fibroadenoma

et al. 2015

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Fibroadenomas are the most common benign breast lesions in adolescent and young women. It is most frequently observed in the 3rd decade. Although it is considered benign, evidence of malignant transformation is available. Cancer development may be from ground of fibroadenoma or near breast tissue. A case of a fibroadenoma coexisting with an invasive ductal carcinoma of the breast in a 31-year-old female is presented. The patient presented with the chief complaint of having a palpable mass in her right breast for the last 10 years. Mammography revealed a mass with microcalcifications. Core biopsy was performed, and the results indicated an invasive carcinoma. Breast-conserving surgery with sentinel lymph node biopsy was performed. The pathological features revealed a fibroadenoma coexisting with an invasive ductal carcinoma. This case suggests that clinicians and radiologists should always pay attention to the associated malignant imaging characteristics whenever a mass was followed up as fibroadenoma.

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“…Although, fibroadenoma is generally considered benign, there is evidence for an association with an increased risk of invasive breast cancer 4. Furthermore, progression of the epithelial component to carcinoma in situ and invasive carcinoma has been documented in the literature 5–8. Malignant transformation from fibroadenoma to cancer is rare.…”

Section: Introductionmentioning

confidence: 99%