Infiltrating giant cellular blue naevus

Abstract

Introduction:Cellular blue naevi (CBN) measure 1–2 cm in diameter and affect the dermis, occasionally extending into the subcutaneous fat. The case of a 14-year-old boy with a giant CBN (GCBN) involving the right half of the face, the jugal mucosa and the lower eyelid with a tumour that had infiltrated the bone and the maxillary and ethmoidal sinuses is reported.Methods:Biopsies were taken from the skin, jugal mucosa and maxillary sinus. The following markers were used in the immunohistochemical evaluation: CD34, CD56, HMB-45, anti-S100, A-103, Melan A and MIB-1.Results:The biopsy specimens showed a biphasic pattern affecting the lower dermis, subcutaneous fat, skeletal muscle, bone, jugal mucosa and maxillary sinus, but there was no histological evidence of malignancy. The tumour cells were CD34−, CD56−, HMB45+, anti-S100+ and A-103+. Melan A was focally expressed. No positive MIB-1 cells were identified.Discussion:The present case shows that GCBN may infiltrate deeply, with no evidence of malignancy.

Pigmented lesions in children: when to worry

“…Malignant blue nevi (a type of melanoma) have been reported, especially within cellular blue nevi located on the scalp; in addition, cellular blue nevi may infiltrate deeply into local tissues in the absence of malignancy [85]. Although small, stable blue nevi require no intervention, lesions appearing suddenly or undergoing clinical change should be biopsied.…”

Orbital cellular blue nevus complicated by malignant melanoma

“…3 There are case reports describing CBN with respect to their anatomical location, size, and concern regarding malignant transformation. [3][4][5] Both the common and cellular blue nevi represent benign congenital entities within a spectrum of melanocytic tumours that contain dendritic and spindled melanocytes. Common blue nevi generally occur on the hands, feet, head, and neck region, whereas the cellular type has a propensity for the thigh and sacrococcygeal region.…”

“…4 These properties make PFCLs ideal substances to unfold and stabilize the retina, in addition to displacing subretinal fluid anteriorly. 5 PFCLs are used intraoperatively but are removed at the end of surgery to avoid inflammation mediated by toxicity that has been reported in animal and human studies. 6,7 We report a case of retained perfluoro-n-octane (PFO), a PFCL, and subsequent leakage into the orbit after its use for a retinal detachment in a globe with a perforating eye injury.…”

Cellular blue nevus (CBN) lymph node metastases of the neck with no primary skin lesion: A case report and review of literature

“…The ''cellular'' BN (CBN), first described by Allen in 1949, usually appears on the skin of the buttocks, the head and neck and the extremities as a small melanocytic tumour of the dermis and subdermal tissue (Leopold and Richards, 1967). Clinical observations have shown that the CBN can become very large (Bittencourt et al, 2007) and infiltrate the subcutaneous soft tissue such as muscle, tendon or the bone of the scalp (Micali et al, 1997). Regional lymph node involvement (Misago et al, 2008) and the appearance of ''benign'' metastases to regional lymph nodes by a CBN are rare, but well documented (Bortolani et al, 1994;Gonzalez-Campora et al, 1994).…”