Infiltrating lobular carcinoma. Is it different from infiltrating duct carcinoma?

Silverstein, Melvin J.; Lewinsky, Bernard S.; Waisman, James; Gierson, Eugene D.; Colburn, William J.; Senofsky, Gregory M.; Gamagami, Purvis

doi:10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b

Cited by 212 publications

(129 citation statements)

References 19 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…In line with the present findings, Dixon et al (1985) found in their series of 105 patients that those with ILC have better outcome than those with IDC. A similar conclusion was reached by Du Toit et al (1991) and Silverstein et al (1994) in their studies consisting of 171 and 161 patients respectively. DiCostanzo et al (1990) compared survival of 230 patients with ILC with stagematched patients with IDC.…”

Section: Discussionsupporting

confidence: 82%

“…ILCs have also. been found to be associated with a low histological grade by others (Silverstein et al, 1994;Sastre-Garau et al, 1996), but reports on the frequency of axillary nodal involvement are contradictory (Silverstein et al, 1994;Sastre-Garau et al, 1996). ILCs have been reported to express more often oestrogen and progesterone receptors (Helin et al, 1989;Sastre-Garau et al, 1996) and less often erbB-2 and p53 oncogenes (Toikkanen et al, 1992;Rosen et al, 1995) than IDCs, and their bcl-2 expression has been reported to be stronger than that of IDCs (Joensuu et al, 1994); these findings also suggest that ILC is biologically less aggressive than IDC.…”

Section: Discussionmentioning

confidence: 99%

“…There is general agreement that patients with ISC have significantly better prognosis than those with IDC or ILC, but there is still controversy as to whether the prognoses of IDC and ILC differ (Howell and Harris, 1985;DiCostanzo et al, 1990;Sastre-Garau et al, 1996). The studies performed to solve this issue have mostly been based on a small number of patients, and relatively few reports including more than 100 cases have been published so far (Dixon et al, 1982;DiCostanzo et al, 1990;du Toit et al, 1991;Silverstein et al, 1994). Moreover, only a few reports are based on a well-defined cohort, and there is little data available comparing long-term survival of patients with ILC with that of patients with IDC (Sastre-Garau et al, 1996).…”

mentioning

confidence: 99%

See 2 more Smart Citations

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

Toikkanen

Pylkkänen²,

Joensuu³

1997

Br J Cancer

146

105

View full text Add to dashboard Cite

Invasive lobular carcinoma of the breast has better short-and long-term survival than invasive ductal carcinoma S Toikkanen', L Pylkkanen2and H Joensuu3Departments of 'Pathology and 2Oncology, University Central Hospital of Turku, Kiinamyllynkatu 10, FIN-20520 Turku, Finland; 3Department of Oncology, University Central Hospital of Helsinki, Haartmaninkatu 4, Helsinki, Finland Summary The outcome and prognostic factors of 217 women with invasive lobular carcinoma (ILC) and those of 1121 women with invasive ductal carcinoma (IDC) of the breast were compared. The patients were followed up for 10-43 years. Women with ILC had axillary nodal metastases less frequently than those with IDC (43% vs 53%, P= 0.02), although there was no difference in the primary tumour size between the groups. ILCs were more frequently of low grade, had lower mitotic counts and had less tumour necrosis. Furthermore, ILCs had lower Sphase fractions and were more often DNA diploid in flow cytometric analysis than IDCs (P < 0.0001 for all comparisons). The 5-and 30-year corrected survival rates of women with ILC were 78% and 50%, respectively, compared with 63% and 37% for women with IDC (P = 0.001). Small pTl NOMO ILCs (n = 41) had 100% 1 0-year and 83% 20-year corrected survival rates. In a multivariate analysis, a large primary tumour size, the presence of axillary nodal metastases, a high mitotic count and the presence of tumour necrosis all had an independent prognostic value in ILC. We conclude that ILC is associated with better survival than IDC.

show abstract

Section: Discussionsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

See 1 more Smart Citation

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

Toikkanen

Pylkkänen²,

Joensuu³

1997

Br J Cancer

146

105

View full text Add to dashboard Cite

show abstract

“…The morphology categories special type and comedocarcinoma were associated with lower RERs of death than infiltracting ductal carcinoma (Table 5). The special type category includes, tubular, mucinous and papillary histotypes, which were reported to have good prognoses in a previous population-based study (Li et al, 2003), and in other studies (Cooper et al, 1978;Fisher et al, 1980;Wargotz and Silverberg, 1988;Ellis et al, 1992;Silverstein et al, 1994;Pedersen et al, 1995;Reinfuss et al, 1995;Toikkanen et al, 1997;Diab et al, 1999). Comedocarcinoma also had a relatively good prognosis in a previous study (Li et al, 2003).…”

Section: Discussionmentioning

confidence: 77%

Prognostic value of morphology and hormone receptor status in breast cancer – a population-based study

et al. 2004

View full text Add to dashboard Cite

We analysed the 5-year relative survival among 4473 breast cancer cases diagnosed in 1990 -1992 from cancer registries in Estonia, France, Italy, Spain, the Netherlands and the UK. Among eight categories based on ICD-O codes (infiltrating ductal carcinoma, lobular plus mixed carcinoma, comedocarcinoma, 'special types', medullary carcinoma, not otherwise specified (NOS) carcinoma, other carcinoma and cancer without microscopic confirmation), the 5-year relative survival ranged from 66% (95% CI 61 -71) for NOS carcinoma to 95% (95% CI 90 -100) for special types (tubular, apocrine, cribriform, papillary, mucinous and signet ring cell); 27% (95% CI 18 -36) for cases without microscopic confirmation. Differences in 5-year relative survival by tumor morphology and hormone receptor status were modelled using a multiple regression approach based on generalised linear models. Morphology and hormone receptor status were confirmed as significant survival predictors in this population-based study, even after adjusting for age and stage at diagnosis.

show abstract

“…Further, the differences in stage, tumour size, and lymph node status observed here may reflect differences in the utility of screening approaches to detect different histologic types of cancer. For example, it is well known that lobular tumours are more difficult to detect with mammography compared to ductal tumours, and this is thought to be primarily due to the fact that lobular tumours tend to grow as linear strands or sheets of cancer cells rather than as more discrete masses, explaining why they are more likely to be diagnosed at a more advanced stage (Davis et al, 1979;Dixon et al, 1982;Silverstein et al, 1994;Yeatman et al, 1995). Thus, currently, available breast cancer screening tools appear to be relatively less or relatively more effective in detecting different histopathologic types of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics of different histologic types of breast cancer

2005

View full text Add to dashboard Cite

Breast cancer is a heterogeneous disease, though little is known about some of its rarer forms, including certain histologic types. Using Surveillance, Epidemiology, and End Results Program data on 135 157 invasive breast cancer cases diagnosed from 1992 to 2001, relationships between nine histologic types of breast cancer and various tumour characteristics were assessed. Among women aged 50 -89 years at diagnosis, lobular and ductal/lobular carcinoma cases were more likely to be diagnosed with stage III/IV, X5.0 cm, and node-positive tumours compared to ductal carcinoma cases. Mucinous, comedo, tubular, and medullary carcinomas were less likely to present at an advanced stage. Lobular, ductal/lobular, mucinous, tubular, and papillary carcinomas were less likely, and comedo, medullary, and inflammatory carcinomas were more likely to be oestrogen receptor (ER) negative/progesterone receptor (PR) negative and high grade (notably, 68.2% of medullary carcinomas were ERÀ/PRÀ vs 19.3% of ductal carcinomas). In general, similar differences were observed among women diagnosed at age 30 -49 years. Inflammatory carcinomas are associated with more aggressive tumour phenotypes, and mucinous, tubular, and papillary tumours are associated with less aggressive phenotypes. The histologic types of breast cancer studied here differ greatly in their clinical presentations, and the differences in their hormone receptor profiles and grades point to their likely different aetiologies. British Journal of Cancer (2005) Although breast cancer remains the most commonly diagnosed cancer among women in the United States (US) and worldwide, it is a heterogeneous disease. Breast cancer can be categorized in several ways, including based on its clinical features, its expression of tumour markers, and its histologic type. The two most common histologic types of invasive breast cancer are ductal and lobular carcinomas, accounting for approximately 75 and 15% of all cases in the US, respectively (Li et al, 2003a). Interest in lobular carcinoma in particular has recently been piqued by data indicating that incidence rates of lobular carcinoma are increasing more rapidly than are rates of ductal carcinoma in the US. Specifically, lobular rates have increased by 65% from 1987 to 1999, while rates of ductal carcinoma have increased only by 3% (Li et al, 2003a). Studies also suggest that lobular carcinomas are more likely than ductal carcinomas to be hormone receptor positive (Arpino et al, 2004;Korhonen et al, 2004). This difference may partly explain why seven studies have consistently observed that combined oestrogen and progestin postmenopausal hormone use is more strongly related to lobular carcinoma risk than to ductal carcinoma risk (Li et al, 2000(Li et al, , 2003bChen et al, 2002;Newcomb et al, 2002;Daling et al, 2003;Newcomer et al, 2003).While several studies have now examined the clinical, pathologic, and epidemiologic differences between ductal and lobular carcinomas, much less is known about the rarer histologic types of breast cancer,...

show abstract

Infiltrating lobular carcinoma. Is it different from infiltrating duct carcinoma?

Cited by 212 publications

References 19 publications

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

Invasive lobular carcinoma of the breast has better short- and long-term survival than invasive ductal carcinoma

Prognostic value of morphology and hormone receptor status in breast cancer – a population-based study

Clinical characteristics of different histologic types of breast cancer

Contact Info

Product

Resources

About