Infiltrating/Sealing Proximal Caries Lesions

Abstract

This randomized split-mouth controlled clinical trial aimed at assessing the therapeutic effects of infiltration vs. sealing for controlling caries progression on proximal surfaces. Out of 90 adult students/patients assessed at university clinics and agreeing to participate, 39, each with 3 proximal lesions identified radiographically around the enamel-dentin junction to the outer third of the dentin, were included. Lesions were randomly allocated for treatment to test-A (Infiltration: ICON-pre-product; DMG), test-B (Sealing: Prime-Bond-NT; Dentsply), or control-C (Placebo). Primary outcome after 1, 2, and 3 yrs of radiographically observed lesion progression was assessed by an independent examiner blinded to groups, using pair-wise and digital-subtraction readings. No adverse events occurred. In 37 participants assessed after 3 yrs, 10 lesions (A-4; B-2; C-4) progressed deep into dentin and needed operative treatment. The 3-year therapeutic effect, based on pair-wise radiographic readings between infiltration and placebo, was 37.8% (95% CI: 20.5-55.2%) and that between sealing and placebo was 29.7% (95% CI: 20.2-35.0%). One-year follow-up digital-subtraction readings showed significant differences in lesion progression between infiltration and placebo (P = 0.0012) and between sealing and placebo (P = 0.0269). The study showed that infiltration and sealing are significantly better than placebo treatment for controlling caries progression on proximal lesions. No significant difference was seen between infiltration and sealing (ClinicalTrials.gov number NCT01417832).

Effect of resin infiltration on enamel surface properties and <i>Streptococcus mutans</i> adhesion to artificial enamel lesions

“…Therefore, a resin-infiltrated layer should be able to strengthen the demineralized enamel structure and prevent further wear and cavitation. Some clinical studies have reported that micro-invasive caries treatment with resin infiltration was an effective and safe approach to arrest initial caries lesions and preserve demineralized enamel [27][28][29] . Findings of this study agreed with those reported by Torres et al 6) and Paris et al 13) , in that the microhardness of carious lesions was significantly improved with resin infiltration.…”

Klinischer Effekt biomimetischer Mineralisation bei Approximalkaries

“…Diese Methode verhindert das Fortschreiten der Läsion über einen Zeitraum von 3 Jahren signifikant wirksamer, als wenn keine Behandlung durchgeführt wird [16]. Die Auswertung der Ergebnisse erfolgte anhand direkter Bewertung von Bissflügelaufnahmen und Subtraktionsradiographie.…”

Evaluation of resin infiltration on demineralized root surface: An <i>in vitro</i> study

“…In recent years, a micro-invasive treatment with a low-viscosity resin-infiltrant has become one of the options for non-cavitated enamel caries. Resin infiltration on enamel caries has been clinically proven to effectively arrest and stabilize lesions [9][10][11] . It has also been proven to significantly increase micro-hardness and reduce mineral loss after a demineralization challenge compared with untreated lesions 12) .…”