Faced with the requirements of curriculum reform in Chinese-foreign cooperation in running schools, this article explores the reform of the compulsory courses "Logistics System Simulation" for logistics engineering majors. Based on the OBE (Outcome based education) education philosophy, with students as the center, specific goals are proposed for course learning in terms of knowledge, application, integration, emotion, value and learning. Then, teaching contents are designed and teaching methods are studied. Finally, course assessment is explored.