Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma

Cunha, Lucas Leite; Morari, Elaine Cristina; Guihen, Ana Carolina Trindade; Razolli, Daniela S.; Gerhard, Renê; Nonogaki, Suely; Soares, Fernando Augusto; Vassallo, José; Ward, Laura Sterian

doi:10.1111/j.1365-2265.2012.04482.x

Cited by 139 publications

(158 citation statements)

References 25 publications

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“…105 However, in TC, the extent of tumor-infiltrating CD4 C cells does not appear to predict patient outcome. 90,102 No differences were found between PTC and MNG patients, with respect to tissue or peripheral blood CD4 C cell frequencies. 18 Interestingly, a double negative CD4 ¡ CD8 ¡ lymphocyte population has been recently identified in TC.…”

Section: Natural Killer T Cells (Nkt) Gd T Cells and Innate Lymphoidmentioning

confidence: 87%

“…101 In a wide immunohistochemical characterization of the immune cell infiltrate in patients with chronic lymphocytic thyroiditis concurrent with DTC, a high CD8 C T lymphocyte infiltration was associated with improved disease free survival. 90 By contrast, in a recent study conducted in a wide cohort of DTC patients, including papillary and follicular subtypes, immunohistochemical analysis of tumor samples revealed that combined enrichment of CD8 C cells and Cox-2 overexpression correlated with the highest risk of disease relapse. In the majority of tumor samples analyzed (68%), CD8 C cells were granzyme B negative, reflecting a state of anergy.…”

Section: Natural Killer T Cells (Nkt) Gd T Cells and Innate Lymphoidmentioning

confidence: 94%

“…89 The only study investigating the significance of TC-infiltrating MDSCs failed to find an association between MDSC density and patient survival. 90 Indeed, in a wide cohort of histological samples from 398 TC patients (253 PTCs and 13 FTCs) MDSCs were identified as CD11b C and CD33 C cells. Intratumoral MDSC count did not correlate with patient clinic-pathological features.…”

Section: Mdscs: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

“…Intratumoral MDSC count did not correlate with patient clinic-pathological features. 90 Unfortunately, the identification of human MDSCs is complicated by the lack of specific marker. Moreover, it has been suggested that several human MDSC phenotypes can be endowed with suppressive activity.…”

Section: Mdscs: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

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The immune network in thyroid cancer

2016

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The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.

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Section: Natural Killer T Cells (Nkt) Gd T Cells and Innate Lymphoidmentioning

confidence: 87%

Section: Natural Killer T Cells (Nkt) Gd T Cells and Innate Lymphoidmentioning

confidence: 94%

Section: Mdscs: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

Section: Mdscs: Myeloid-derived Suppressor Cellsmentioning

confidence: 99%

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The immune network in thyroid cancer

2016

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“…Regarding Th17 cells, authors reported also an increased mRNA expression of IL-17A and accumulation of Th17 cells within the tumor that may contribute to cancer development. Cunha et al (2012) found increased immune cells in-filtrating in the malignant tissue of patients with differentiated thyroid carcinoma than in benign lesion. They observed increased Th17 and Tregs cells in the malignant tissue associating with favorable prognostic features.…”

Section: Adaptative Immune and Cancermentioning

confidence: 94%

Immunological Processes in Cancer: A Link Between Inflammation and Immunity

Victorino¹,

Jeremias

Assunção³

2014

American Journal of Immunology

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Cancer is a worldwide issue and one of the most relevant death causes in child and adults. There are several causes that can lead to cancer development. It is well known that inflammation is one known hallmark of cancer and it favors tumor cells growth. Several alterations in immunological and inflammatory processes are caused in response to tumor presence and both innate and adaptive immunity have effective mechanism to destroy tumor cells. Nevertheless, distinct tumor types developed mechanisms to evade anti-tumor immunological responses. Here, we revise researches regarding inflammation and immune response during cancer development, as well as cancer signaling pathways and immunotherapy that have been performed in Brazil. The better understanding of the mechanisms regarding cancer and immunological processes is of huge importance and it may support the development of new cancer targets.

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OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer

et al. 2021

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Background Papillary thyroid cancer (PTC) is the most common type of thyroid cancer. However, due to the lack of reliable prognostic biomarkers for PTC, overtreatment has been on the rise. Therefore, our research aims to identify new and promising prognostic biomarkers and provide fresh perspectives for clinical decision making. Methods The RNA‐seq data and clinical data of PTC samples were obtained from The Cancer Genome Atlas data portal. GSE64912 and GSE83520 datasets were downloaded through the GEOquery R package. The difference in the expression of oxoglutarate dehydrogenase like ( OGDHL ) between PTC and normal tissues was explored by the Wilcoxon test. Kaplan–Meier (KM) and Cox regression analyses were used to further explore the prognostic value of OGDHL . The tumor microenvironments of PTC patients were explored based on ssGSEA and Tumor Immune Estimation Resource online database. Gene Set Enrichment Analysis (GSEA) was performed to explore the biological processes associated with OGDHL . Results The expression level of OGDHL in PTC was significantly altered compared to that in normal tissues ( p < 0.05). Various biological processes associated with OGDHL were also explored through GSEA. KM analysis suggested that the low‐ OGDHL group had a better overall survival [OS, p = 3.49e‐03, hazard ratio (HR) = 4.567]. The receiver operating characteristic curve also indicated the favorable prognostic potential of OGDHL . Moreover, OGDHL was proved to be an independent prognostic indicator in Cox analysis ( p = 1.33e‐02, HR = 0.152). In the analysis of the tumor microenvironment, the low‐ OGDHL group showed a lower immune score and stromal score, while tumor purity was higher. The expression of OGDHL was also closely correlated with the infiltration of immune cells. Conclusion Our study elucidated the influence of OGDHL on the prognosis of PTC and demonstrated its potential as a novel biomarker, which would provide new insights into the prognosis monitoring and clinical decision making in PTC patients.

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Infiltration of a mixture of immune cells may be related to good prognosis in patients with differentiated thyroid carcinoma

Abstract: Our data suggest that the tumour or peri-tumoural microenvironment may act to modify the observed pattern of immune response. Immune cell infiltration and the presence of concurrent CLT helped characterize specific tumour histotypes associated with favourable prognostic features.

Cited by 139 publications

References 25 publications

The immune network in thyroid cancer

The immune network in thyroid cancer

Immunological Processes in Cancer: A Link Between Inflammation and Immunity

OGDHL closely associates with tumor microenvironment and can serve as a prognostic biomarker for papillary thyroid cancer

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