Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer

Zhang, Z; Huang, Jinyan; Zhang, C; Yang, Hongjiang; Qiu, Hongbing; Li, J; Liu, Y; Qin, Lijun; Wang, L; Hao, Shuwei; F, Zhang; Wang, X; Shan, Baoen

doi:10.1038/cgt.2015.7

Cited by 30 publications

(29 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…9 Histopathological analysis of a variety of human tumors showed high concentrations of T lymphocytes is associated with better prognosis in melanoma, breast cancer, prostate cancer, non-Hodgkin lymphoma, head and neck cancer, NSCLC, esophageal cancer and urethral carcinoma. 10, 11, 12 In an earlier study of NSCLC, a large number of tumor infiltrating CD8+ T cells were found to induce tumor cell apoptosis. 13 CD4+ T and B lymphocytes are a double-edged sword in tumor immunity.…”

Section: Discussionmentioning

confidence: 99%

Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer

Yan

et al. 2017

Cancer Gene Ther

View full text Add to dashboard Cite

Dynamic interaction between tumor cells and the microenvironment is critical for tumorigenesis, and cancer immunosurveillance plays an important role in the tumor evolution. In some tumors (such as esophageal cancer, pancreatic cancer and colorectal cancer), studies have shown that the number of tumor-infiltrating lymphocytes (TILs) has a significant relationship with the prognosis, but there is little research on the prognosis of TILs and non-small cell lung cancer (NSCLC) has been performed. Therefore, it is necessary to discover the relationship between the TILs and cytokines with NSCLC prognosis and metastasis in patients. Tumor samples were carefully examined for tissue preservation and complete follow-up. A total of 107 tumor samples from NSCLC patients with radical surgical resection were enrolled for the analysis. All samples were subjected to immunohistochemistry for detection of CD3, CD4, CD8, CD28, forkhead box protein P3 (Foxp3), cytotoxic T lymphocyte-associated protein-4, cyclooxygenase2 (COX-2), transforming growth factor β 1, interleukin-2 (IL-2), interleukin-6, interleukin-10, interleukin-12 receptor and hypoxia inducible factor 1a (HIF-1a). The number, function and location of the targets were analyzed to determine their correlation with disease-free survival (DFS) and overall survival (OS). Immunhistochemical results from 107 samples indicated that the FoxP3+ regulatory TIL (HR=1.336, P=0.031), IL-2 (HR=0.595, P=0.007) and HIF-1a (HR=1.510, P=0.002) levels in tumor cells closely correlated with DFS in a COX analysis model. FoxP3+ regulatory TILs (HR=1.566, P=0.002) significantly correlated with OS and tumor node metastasis staging. The patients were divided into two groups due to the coexpression pattern of the IL-2, FoxP3+ and HIF-1a. The high-risk group had an overall worse survival than those at low risk. We confirmed that Foxp3 expression in lymphocyte and IL-2 expression in tumor cells were associated with recurrence or transfer. Furthermore, we also observed that HIF-1a expression significantly correlated with DFS and OS.

show abstract

Section: Discussionmentioning

confidence: 99%

Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer

Yan

et al. 2017

Cancer Gene Ther

View full text Add to dashboard Cite

show abstract

“…In addition, the correlation between increased CD8 + T-cell infiltration and good clinical outcome was recently described in the previous unstudied neoplasias, including GIST (Rusakiewicz et al, 2013), oropharyngeal ( Jung et al, 2013;Näsman et al, 2012;Wansom et al, 2012), thyroid (Cunha et al, 2012), and biliary tract cancer (Goeppert et al, 2013). Poor (Salvesen & Akslen, 1999) Good Poor (Lan et al, 2013) Good (Eisenthal et al, 2001;Zhang et al, 2015) Good Sato et al, 2005;Zhang et al, 2003) Oesophageal cancer -Poor (Guo et al, 2007) Poor (Shigeoka et al, 2013) Good (Furihata et al, 1992;Ishigami et al, 2003aIshigami et al, , 2003bLu et al, 2013) Good (Hsia et al, 2005) Colorectal cancer Good (Bindea et al, 2013;Menon et al, 2004) Poor (BarberaGuillem et al,…”

Section: Role Of T Cellsmentioning

confidence: 90%

“…Their link with clinical prognosis has been reported in a variety of human solid tumors. The majority of these studies report that an extensive infiltration with DC is associated with increased OS and cover many tumors types, including melanoma (Gerber et al, 2014;Ladányi et al, 2007;Neagu et al, 2013;Simonetti et al, 2007), HCC (Cai et al, 2006;Yin et al, 2003), gallbladder (Furihata et al, 2005;Nakakubo et al, 2003), oral (Reichert et al, 2001), esophageal (Furihata et al, 1992;Ishigami et al, 2003a;Lu et al, 2013), gastric (Amoueian et al, 2015Ananiev et al, 2011;Kashimura et al, 2012;Tsukayama et al, 2005), NSCLC (Al-Shibli et al, 2009;Dai et al, 2010;Hald et al, 2013;Inoshima et al, 2002;Johnson et al, 2000), colorectal (Gulubova et al, 2012;McMullen et al, 2010;Nakayama et al, 2003;Väyrynen et al, 2014), bladder (Inoue et al, 1993), breast (Iwamoto et al, 2003;La Rocca et al, 2008;Lespagnard et al, 1999;Park et al, 2012), endometrial (Honig et al, 2005;Lijun et al, 2012), and ovarian cancer (Eisenthal et al, 2001;Zhang et al, 2015). Nevertheless, the infiltration with CD123 + plasmacytoid DC has been associated with shorter OS in breast cancer ( Jensen et al, 2012;Treilleux et al, 2004), as well as the presence of CD208 + and CD1a + DCs in colorectal (Sandel et al, 2005)...…”

Section: Role Of Dcsmentioning

confidence: 95%

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

Becht¹,

Giraldo²,

Germain³

et al. 2016

Advances in Immunology

181

136

View full text Add to dashboard Cite

“…It is possible that this is a direct consequence of the cancer-mediated altered myelopoiesis but it could also be the outcome of a PGE2-driven redirected differentiation of DC to mMDSC. 36 DC are an important component of the EOC microenvironment of patients with better survival, 37 hence therapeutic approaches to normalize their levels are warranted. Potentially, targeting PGE2 may be of help.…”

Section: Discussionmentioning

confidence: 99%

The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival

et al. 2018

View full text Add to dashboard Cite

Epithelial ovarian cancer (EOC) may cause abnormal blood levels of leukocytes. This paraneoplastic manifestation is associated with a worse response to therapy and shorter survival. To understand the complexity and nature of these leukocytes, we dissected the different populations of myeloid cells and analyzed their relation to clinical outcome. Therefore, baseline blood samples of 36 EOC patients treated either with carboplatin/doxorubucin or with gemcitabine were analyzed for different subsets of monocytes/macrophages, myeloid derived suppressor cells (MDSC) and dendritic cells (DC) using multiparameter flow cytometry as well as functional assays for myeloid cell mediated suppression of antigen-specific T cell reactivity. Healthy donor blood served as control. EOC patients displayed an increase in monocytes/macrophages, monocytic MDSC (mMDSC) and CD33-CD11b+CD14-CD15- double-negative MDSC (CD33- dnMDSC) and a decrease in the frequency of DC, across all EOC subtypes. A low frequency of DC and high frequencies of monocytes/macrophages and mMDSC, but not CD33- dnMDSC, were associated with poor overall survival. Patient's monocytes/macrophages and mMDSC, but not CD33- dnMDSC, were shown to suppress T cell reactivity in vitro. The mMDSC and DC frequencies were not altered upon treatment. Importantly, the mMDSC to DC ratio was the strongest independent, highly sensitive and specific, predictive factor for survival. This was irrespective of the type of chemotherapy or disease stage and outperformed classical parameters as WHO status or time from last chemotherapy. Thus, the baseline blood mMDSC to DC ratio is a robust, independent and easy to analyze predictive factor for EOC survival, and may assist patient selection for immunotherapy.

show abstract

Infiltration of dendritic cells and T lymphocytes predicts favorable outcome in epithelial ovarian cancer

Cited by 30 publications

References 12 publications

Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer

Tumor-associated immune factors are associated with recurrence and metastasis in non-small cell lung cancer

Immune Contexture, Immunoscore, and Malignant Cell Molecular Subgroups for Prognostic and Theranostic Classifications of Cancers

The blood mMDSC to DC ratio is a sensitive and easy to assess independent predictive factor for epithelial ovarian cancer survival

Contact Info

Product

Resources

About