Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life

Wang-Saegusa, Ana; Cugat, Ramón; Ares, Óscar; Seijas, Roberto; Cuscó, Xavier; García-Balletbó, Montserrat

doi:10.1007/s00402-010-1167-3

Cited by 212 publications

(157 citation statements)

References 24 publications

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“…13,[24][25][26][27][28] Although these studies may provide evidence in regard to the safety of the PRP procedure, due to the lack of comparator, they cannot give an insight into the effectiveness of the procedure. The largest case series described the results of 261 patients injected three times with PRP at 2-week intervals.…”

Section: Resultsmentioning

confidence: 99%

“…At 6-month follow-up, clinically significant improvements in arthritis scores, quality of life (SF-36), and functional scores were reported when compared with baseline values, with no adverse events described. 28 The case series with the longest follow-up period reported on 91 patients who received three injections of PRP given at 3-weekly intervals. A decrease in pain and an increase in function scores were reported after 12 months when compared with baseline.…”

Section: Resultsmentioning

confidence: 99%

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Platelet-rich plasma: a case study for the identification of disinvestment opportunities using horizon scanning

Mundy

2017

Aust. Health Review

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Objective. This paper discusses the potential for horizon scanning to identify low-value, inappropriate clinical practices that deliver minimal benefit to patients and represent a considerable financial burden on the health system.Methods. Platelet-rich plasma (PRP) was identified by routine horizon scanning as a potentially innovative treatment alternative for osteoarthritis of the knee. A rapid, non-systematic assessment of the evidence pertaining to the safety and effectiveness of PRP compared with nonsteroidal anti-inflammatory drugs (NSAIDs) for the treatment of osteoarthritis of the knee was conducted.Results. The evidence base supporting the use of PRP for the treatment of osteoarthritis was poor. No comparative studies were identified that compared the use of PRP to NSAIDs, the current treatment option for osteoarthritis of the knee in Australia. Despite the lack of effectiveness evidence, the use of PRP injections was rapidly increasing in the private sector using an inappropriate Medicare Benefits Schedule item number.Conclusions. This assessment highlights the potential of using established horizon scanning methodologies to identify targets for full or partial disinvestment of ineffective, inefficient or harmful clinical practices.What is known about the topic? PRP is rapidly diffusing in the private health system in Australia, however the use of a Medicare Benefits Schedule item number meant that this practice was being subsidised by the public reimbursement of treatment fees. What does this paper add? Traditional horizon scanning tends to identify technologies for health systems to invest in. The evidence on the effectiveness of PRP was examined with the purpose of exploring investment in an innovative treatment that may have reduced the number of invasive procedures being performed in the public hospital system. The current evidence base does not support the use of PRP injections for the treatment of osteoarthritis. It does, however, support the use of horizon scanning as an inexpensive methodology to identify possible disinvestment targets associated with potential patient harm and high health service expenditure. What are the implications for practitioners? Practitioners should be aware that public funding for the injection of PRP should not be used for the treatment of osteoarthritis.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Platelet-rich plasma: a case study for the identification of disinvestment opportunities using horizon scanning

Mundy

2017

Aust. Health Review

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“…15 Wang Saegusa et al reported improvement of VAS, SF-36, and Western Ontario and McMaster Universities (WOMAC) scores at the 6-month follow-up in 261 patients with OA symptoms more than 3 months who had 3 intra-articular injection of autologous PRGF at 2-week intervals. 16 Filardo et al reported that 3 injections of intra-articular PRP in 90 patients with chronic knee degenerative conditions revealed improvement in International Knee Documentation Committee (IKDC) and EQ-VAS scores at the 2-year follow-up and that it had discernible positive effects especially on younger patients with early osteoarthritis. 17 However which growth factors are more beneficial needs better understanding.…”

Section: Discussionmentioning

confidence: 99%

To assess the effects of platelet rich plasma application on pain in osteoarthritis knee

et al. 2017

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Background: Platelet rich plasma (PRP) is a concentrate extract of platelets from autologous blood. It is known to increase growth factor of plasma and helps to heal the injured tissue. Platelet-rich plasma (PRP) is an autologous biologic treatment including patients own plasma, containing growth factors released from platelets. The rationale for the use of PRP is to stimulate the natural healing cascade and tissue regeneration by an increase release of platelet-derived factors directly at the site of treatment. This study is done to assess the effects of platelet rich plasma application on pain in osteoarthritis knee.Methods: Total of 40 cases was included in this study (18 male and 22 females) with mean age of 57.3 (Range 35-75). All patients received intra-articular PRP injection. This study was conducted on the patients coming to orthopaedic department at MGM medical college and hospital, Navi Mumbai.Results: In this study it was found that there is decrease in pain on vas pain score, with increasing time. We followed up the patients for period of 3 months. We found that average mean VAS score was decreased from 6.0 to 4.13 after follow up of 3 months after a single dose of intra-articular PRP injection. Conclusions: PRP is an effective treatment for pain in OA knee. It is one of the new approaches in the field of orthopaedics to solve the issues of pain management.

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“…2 No major complications were noted in our study which is comparable with other study reports and signifies the safety profile of autologous PRP intra-articular injections. 1,3,4 In our study we have found that low grade OA knee (KL grade 1, 2, 3) have better outcomes as compared to higher grade OA knee (KL grade 4) as well as younger age group (50-55 years) has lower WOMAC score as compared to higher age group (60-65 years) which is comparable to study done by Franca Vaccaro, Rita Guitaldi et al which concluded that better results were achieved in younger patients with a lower degree of cartilage degeneration. 5 Pre-treatment blood analysis of our patients showed an average platelet count of 263.48×10 3 /µl.…”

Section: Discussionmentioning

confidence: 99%

Platelet rich plasma for the treatment of osteoarthrosis knee

Maheshwari

Harshwardhan

2017

Int J Res Orthop

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Background: New studies focused on modern therapeutic methods which stimulate cartilage healing and repair the damage, including the use of platelet-rich plasma (PRP) as a cocktail of growth factors. This study has the purpose to present the use of PRP in management of knee osteoarthrosis and its outcomes up to 6 month follow up.Methods: 58 patients with 100 knees (32 male, 26 female) with Kellgren Lawrence grade 1, 2,3 and 4, aged between 50 to 65 years between February 2015 to December 2015 treated with 4 ml of intra-articular PRP injections at 4 week interval in each affected knee and evaluated using WOMAC and VAS scores before injection and on follow up at end of the 1st, 3rd, and 6th month.Results: The mean age was 58.29 years. Improvement in WOMAC score for KL grade 1 (32.61%), grade 2 (31.12%), grade 3(26.54%) whereas only 13.68% in KL grade 4 at end of 6month follow up. Improvement in VAS score for KL grade 1 (41.30%), grade 2 (38.02%), grade 3 (47.68) whereas only 12.74% in grade 4 at the end of 6 month follow up. Results show statistically higher significant improvement seen in WOMAC and VAS for KL grade 1, 2, and 3 as compared to grade 4 at 6 months follow up.Conclusions: The results of our study illustrated that the treatment with intra articular PRP injections is safe and effective in reducing pain and stiffness as well as improve knee function and quality of life in early stages of knee osteoarthrosis.

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Infiltration of plasma rich in growth factors for osteoarthritis of the knee short-term effects on function and quality of life

Abstract: At 6 months following intra-articular infiltration of PRGF in patients with OA of the knee, improvements in function and quality of life were documented by OA-specific and general clinical assessment instruments. These favourable findings point to consider PRGF as a therapy for OA.

Cited by 212 publications

References 24 publications

Platelet-rich plasma: a case study for the identification of disinvestment opportunities using horizon scanning

Platelet-rich plasma: a case study for the identification of disinvestment opportunities using horizon scanning

To assess the effects of platelet rich plasma application on pain in osteoarthritis knee

Platelet rich plasma for the treatment of osteoarthrosis knee

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