Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Wong, Dickson; Danesh‐Meyer, Helen V.; Pon, Jo-Anne

doi:10.1016/j.jocn.2015.04.001

Cited by 8 publications

(6 citation statements)

References 6 publications

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“…Very few cases of indolent NHL involve only the optic nerve (1,2). For patients with lymphomatous optic nerve infiltration, visual loss is severe and is associated with disc swelling, as in this case; peripapillary hemorrhage has also been noted in a few cases (1,3). The majority of patients with lymphoplasmacytic lymphoma have Waldenström macroglobulinemia, which is defined by circulating monoclonal IgM paraprotein.…”

mentioning

confidence: 64%

Isolated Optic Neuropathy as Presenting Sign of Systemic Lymphoma

Ramachandran¹,

Amengual²,

Park³

et al. 2021

Journal of Neuro-Ophthalmology

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confidence: 64%

Isolated Optic Neuropathy as Presenting Sign of Systemic Lymphoma

Ramachandran¹,

Amengual²,

Park³

et al. 2021

Journal of Neuro-Ophthalmology

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“…2 In surgery, optic nerve lymphoma normally appears as an enormous enlarging nerve. 7,28 We performed our biopsy using a minor subfrontal approach, and the result was conclusive.…”

Section: Discussionmentioning

confidence: 88%

Primary non-Hodgkin lymphoma of the chiasm and optic tract in a nonimmunocompromised patient: illustrative case

Kadri¹,

Hamed²,

Anbari

2022

Journal of Neurosurgery: Case Lessons

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BACKGROUND Chiasmatic and optic track lymphoma as the primary lesion of the central nervous system (CNS) is extremely rare. OBSERVATIONS The authors report a case of a previously healthy 62-year-old woman who presented with quick and progressive visual impairment leading to bilateral blindness. Brain imaging studies suggested glioma or lymphoma of the chiasm and the posterior visual pathway. Postoperative examination revealed low-grade malignant B-cell lymphoma. No evidence of extracranial lymphoma was found, so a final diagnosis of primary CNS lymphoma (PCNSL) was made. LESSONS To the authors’ knowledge, PCNSL confined to the optic chiasm has rarely been reported in nonimmunocompromised patients. The present case of lymphoma affecting the optic chiasm and optic tract is extremely rare.

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“…Alternately, our broader search leads us to conclude that the potential for both neoplastic infiltration and the predilection to cause leptomeningeal carcinomatosis/lymphoma of the anterior visual segments is considerably more common. [26][27][28][29][30] Systematic ascertainment has demonstrated a rate as high as 90%, 31 with a concordance rate of systemic involvement in greater than half of those with histopathologic confirmation of lymphomatous infiltration of the optic nerve. 29 A study involving patients with confirmed leptomeningeal carcinomatosis revealed that vision loss was the predominant ocular symptom in over 70%, while half reported that their visual disturbance was their initial and the corresponding symptom which prompted them to seek out medical attention.…”

Section: Discussionmentioning

confidence: 99%

Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery

Maldonado

Lisak

Galetta

et al. 2023

Neurol Neuroimmunol Neuroinflamm

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We describe a woman with a history of relapsing acute optic neuritis and perineuritis. Testing failed to confirm a specific diagnosis; hence, she was diagnosed with seronegative neuromyelitis optica spectrum disorder and treated with the immunotherapy rituximab, later in conjunction with mycophenolate mofetil. She achieved a durable remission for 9 years until she presented with paresthesia affecting her left fifth digit, right proximal thigh, and left foot, while also reporting a 25-pound weight loss over the prior 3 months. New imaging demonstrated a longitudinally extensive and enhancing optic nerve, in conjunction with multifocal enhancing lesions within the spinal cord, in a skip-like distribution. The differential diagnosis is discussed.

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Infiltrative lymphomatous optic neuropathy in non-Hodgkin lymphoma

Cited by 8 publications

References 6 publications

Isolated Optic Neuropathy as Presenting Sign of Systemic Lymphoma

Isolated Optic Neuropathy as Presenting Sign of Systemic Lymphoma

Primary non-Hodgkin lymphoma of the chiasm and optic tract in a nonimmunocompromised patient: illustrative case

Recurrent Optic Neuritis and Perineuritis Followed by an Unexpected Discovery

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