2018
DOI: 10.1016/j.arr.2017.10.003
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Inflammageing and metaflammation: The yin and yang of type 2 diabetes

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Cited by 209 publications
(178 citation statements)
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“…Similar results were later reproduced with various T2DM mouse models . However, because control animals were not treated with glucose‐lowering agents, it is not known whether these effects are the result of the specific activity of SGLT2 inhibitors or reflect the effective amelioration of hyperglycaemia, which, per se , fosters LGI . An elegant study showed that peritoneal macrophages secrete IL‐1β in a glucose‐dependent manner in response to feeding and post‐prandial glycaemic spikes.…”
Section: Evidence Of the Anti‐inflammatory Effect Of Sglt2 Inhibitorsmentioning
confidence: 64%
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“…Similar results were later reproduced with various T2DM mouse models . However, because control animals were not treated with glucose‐lowering agents, it is not known whether these effects are the result of the specific activity of SGLT2 inhibitors or reflect the effective amelioration of hyperglycaemia, which, per se , fosters LGI . An elegant study showed that peritoneal macrophages secrete IL‐1β in a glucose‐dependent manner in response to feeding and post‐prandial glycaemic spikes.…”
Section: Evidence Of the Anti‐inflammatory Effect Of Sglt2 Inhibitorsmentioning
confidence: 64%
“…Accordingly, low‐grade inflammation (LGI) is a recognized factor that contributes to the development and progression of atherosclerosis and is more generally a relevant risk factor for CV disease and mortality . LGI is defined as a chronic, sterile, cold, systemic and multifactorial pro‐inflammatory status . Although LGI involves the same molecules and cell types as the acute inflammatory response, it is chronic and subclinical in nature and contributes to CV disease without showing major signs of the classical inflammatory response.…”
Section: Ketone Bodies: Additional Effects Beyond Metabolismmentioning
confidence: 99%
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