Inflammation, ageing and chronic disease

Pawelec, Graham; Goldeck, David; Derhovanessian, Evelyna

doi:10.1016/j.coi.2014.03.007

Cited by 344 publications

(256 citation statements)

References 53 publications

Supporting

Mentioning

242

Contrasting

Unclassified

Order By: Relevance

“…Inflammation of the skin is associated with the influx of immune cells that can produce ROS and degrading A c c e p t e d M a n u s c r i p t enzymes that will subsequently damage surrounding tissue. Suppression of inflammation delays inflammation-induced aging of the skin (Pawelec et al, 2014).…”

Section: Uv-induced Alterations Resulting In Immunosuppressionmentioning

confidence: 99%

Oxidation events and skin aging

Kammeyer

Luiten

2015

Ageing Research Reviews

721

563

View full text Add to dashboard Cite

Section: Uv-induced Alterations Resulting In Immunosuppressionmentioning

confidence: 99%

Oxidation events and skin aging

Kammeyer

Luiten

2015

Ageing Research Reviews

721

563

View full text Add to dashboard Cite

“…However, only a small number of them have investigated the relationship between age and DNA methylation patterns of genes encoding cytokines [35,51]. Ageing is commonly associated with higher systemic levels of pro-inflammatory cytokines [52]. Nevertheless, ageing-induced differential methylation occurred mostly without change in gene expression [35].…”

Section: Discussionmentioning

confidence: 99%

Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome

Lopez‐Pascual

Lasa²,

Portillo³

et al. 2017

Ann Nutr Metab

View full text Add to dashboard Cite

Background: Deoxyribonucleic acid (DNA) methylation is an epigenetic modification involved in gene expression regulation, usually via gene silencing, which contributes to the risks of many multifactorial diseases. The aim of the present study was to analyze the influence of resting oxygen consumption on global and gene DNA methylation as well as protein secretion of inflammatory markers in blood cells from obese subjects with sleep apnea-hypopnea syndrome (SAHS). Methods: A total of 44 obese participants with SAHS were categorized in 2 groups according to their resting oxygen consumption. DNA methylation levels were evaluated using a methylation-sensitive high resolution melting approach. Results: The analyzed interleukin 6 (IL6) gene cytosine phosphate guanine (CpG) islands showed a hypomethylation, while serum IL-6 was higher in the low compared to the high oxygen consumption group (p < 0.05). Moreover, an age-related loss of DNA methylation of tumor necrosis factor (B = -0.82, 95% CI -1.33 to -0.30) and long interspersed nucleotide element 1 (B = -0.46; 95% CI -0.87 to -0.04) gene CpGs were found. Finally, studied CpG methylation levels of serpin peptidase inhibitor, clade E member 1 (r = 0.43; p = 0.01), and IL6 (r = 0.41; p = 0.02) were positively associated with fat-free mass. Conclusions: These findings suggest a potential role of oxygen in the regulation of inflammatory genes. Oxygen consumption measurement at rest could be proposed as a clinical biomarker of metabolic health.

show abstract

“…The older immune system is less effective, showing reduced responses to infection and vaccination, and increased background levels of autoantibodies and inflammatory cytokines [14][15][16][17][18]. We, and others, have previously shown that the numbers of different types of B cells have changed with age [14,19,20].…”

Section: Introductionmentioning

confidence: 99%

Ageing of the B-cell repertoire

Martin

Kipling

et al. 2015

Phil. Trans. R. Soc. B

View full text Add to dashboard Cite

One contribution of 13 to a theme issue 'The dynamics of antibody repertoires'. Older people are more susceptible to infection, less responsive to vaccination and have a more inflammatory immune environment. Using spectratype analysis, we have previously shown that the B-cell repertoire of older people shows evidence of inappropriate clonal expansions in the absence of challenge, and that this loss of B-cell diversity correlates with poor health. Studies on response to vaccination, using both spectratyping and high-throughput sequencing of the repertoire, indicate that older responses to challenge are lacking in magnitude and/or delayed significantly. Also that some of the biologically significant differences may be in different classes of antibody. We have also previously shown that normal young B-cell repertoires can vary between different phenotypic subsets of B cells. In this paper, we present an analysis of immunoglobulin repertoire in different subclasses of antibody in five different populations of B cell, and show how the repertoire in these different groups changes with age. Although some age-related repertoire differences occur in naive cells, before exogenous antigen exposure, we see indications that there is a general dysregulation of the selective forces that shape memory B-cell populations in older people.

show abstract

Inflammation, ageing and chronic disease

Cited by 344 publications

References 53 publications

Oxidation events and skin aging

Oxidation events and skin aging

Low Oxygen Consumption is Related to a Hypomethylation and an Increased Secretion of IL-6 in Obese Subjects with Sleep Apnea-Hypopnea Syndrome

Ageing of the B-cell repertoire

Contact Info

Product

Resources

About