2014
DOI: 10.1186/1477-5956-12-32
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Inflammation: an important parameter in the search of prostate cancer biomarkers

Abstract: BackgroundA more specific and early diagnostics for prostate cancer (PCa) is highly desirable. In this study, being inflammation the focus of our effort, serum protein profiles were analyzed in order to investigate if this parameter could interfere with the search of discriminating proteins between PCa and benign prostatic hyperplasia (BPH).MethodsPatients with clinical suspect of PCa and candidates for trans-rectal ultrasound guided prostate biopsy (TRUS) were enrolled. Histological specimens were examined in… Show more

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Cited by 26 publications
(25 citation statements)
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“…Jayapalan et al, profiled the serum of patients with PCa and BPH using the geland lectin-based proteomics methods and demonstrated the significant differential expres-sion of apolipoprotein AII (APOA2), complement C3 beta chain fragment, inter-alpha-trypsin inhibitor heavy chain 4 fragment (ITIH4), transthyretin (TTR), alpha-1-antitrypsin (SER-PINA1) and high molecular weight kininogen, light chain (KNG1) between the two groups of patients' samples [78]. In a recent study, the comparison between PCa (with and without inflammation) and BPH (with and without inflammation) serum samples by SELDI-TOF analysis did not show differences in protein expression [79]. However, when samples with inflammation were excluded, 20 significantly different protein peaks were detected.…”
Section: Blood Biomarkersmentioning
confidence: 97%
See 1 more Smart Citation
“…Jayapalan et al, profiled the serum of patients with PCa and BPH using the geland lectin-based proteomics methods and demonstrated the significant differential expres-sion of apolipoprotein AII (APOA2), complement C3 beta chain fragment, inter-alpha-trypsin inhibitor heavy chain 4 fragment (ITIH4), transthyretin (TTR), alpha-1-antitrypsin (SER-PINA1) and high molecular weight kininogen, light chain (KNG1) between the two groups of patients' samples [78]. In a recent study, the comparison between PCa (with and without inflammation) and BPH (with and without inflammation) serum samples by SELDI-TOF analysis did not show differences in protein expression [79]. However, when samples with inflammation were excluded, 20 significantly different protein peaks were detected.…”
Section: Blood Biomarkersmentioning
confidence: 97%
“…Haptoglobin (HP) is a transport protein, secreted in liver and involved in immune response. It appeared as protein with altered abundance and candidate biomarker for PCa in several studies analyzing tissue [54], blood [77,79] and urine [97]. Protein AMBP, secreted by kidneys and gallbladder, has also been found in studies analyzing blood [77,81] and urine [97].…”
Section: Reproducibility and Specificity Of The Biomarkers Discoveredmentioning
confidence: 98%
“…Biomarker results should also correlate with disease extent and have defined relationships with potential confounders including renal function21 and the effect of pleural interventions. The latter is important because the precedent has been established in prostate22 23 and breast cancer24 that recent sampling, resection or peritumoural inflammation may affect biomarker expression. This is particularly relevant to MPM where biopsies are frequently large and often combined with pleurodesis.…”
Section: Introductionmentioning
confidence: 99%
“…Many DNA detection methods have been described, and some are already commercially available. There are few methods that do not require initial treatments, such as PCR or extraction and purification from biological samples using immune chromatography, often used in clinics [8]. These methods are simple and rapid and may be useful in several fields but often give false-positive or false-negative results because of the presence of unrelated DNA or inhibitors or quenchers [9].…”
Section: Introductionmentioning
confidence: 99%