Inflammation and behavioral symptoms in preoperational glioma patients: Is depression, anxiety, and cognitive impairment related to markers of systemic inflammation?

Li, Song; Quan, Xingyun; Su, Lin; Wang, Ke; Wang, Haorun; Wu, Lie; Chen, Chaoyi; Li, Shenjie; Xiang, Wei; Chen, Ligang; Zhou, Jie

doi:10.1002/brb3.1771

Cited by 23 publications

(19 citation statements)

References 33 publications

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“…TNF-α levels may be increased in patients who suffer from depression and is a potential biomarker for diagnosis of depression ( 82 ). In a pre-clinical study based on an animal model, deletion of TNF-α receptors was associated with antidepressant-like effects in behavioural tests compared with the wild-type counterparts ( 83 ). Additionally, a previous study showed that inhibiting the TNF-α signaling pathway may serve as a novel means of investigating how the CNS inflammatory response is associated with depression ( 81 ).…”

Section: Role Of Cytokines In Depression: Mechanism and Treatmentmentioning

confidence: 99%

Flare‑up of cytokines in rheumatoid arthritis and their role in triggering depression: Shared common function and their possible applications in treatment (Review)

Chun-hai

2020

Biomed Rep

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Chronic illnesses are associated with an increased risk of depression and anxiety. Rheumatoid arthritis (RA) is a chronic autoimmune disease that typically causes damage to the joints. RA extensively impacts patients, both physically and psychologically. Depression is a common comorbid disorder with RA, which leads to worsened health outcomes. There are several cytokines that are active in the joints of patients with RA. Inflammatory cytokines serve important roles in the key processes in the joints, which usually cause inflammation, articular damage and other comorbidities associated with RA. The key role of inflammatory cytokines could be attributed to their interactions within signaling pathways. In RA, IL-1, and the cytokines of TNF-α, IL-6 and IL-18 are primarily involved. Furthermore, depression is hypothesized to be strongly associated with systemic inflammation, particularly with dysregulation of the cytokine network. The present review summarizes the current state of knowledge on these two diseases from the perspective of inflammation and cytokines, and emphasizes the possible bridge between them by exploring the involvement of systemic cytokines in both conditions.

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Section: Role Of Cytokines In Depression: Mechanism and Treatmentmentioning

confidence: 99%

Flare‑up of cytokines in rheumatoid arthritis and their role in triggering depression: Shared common function and their possible applications in treatment (Review)

Chun-hai

2020

Biomed Rep

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“…After acute ischemic insult, inflammatory cytokines in the ischemic brain will be upregulated from resident brain cells and infiltrating immune cells, which play complex roles in the pathophysiology of cerebral ischemia (9). Previous evidence supports a relationship of cognition impairment, anxiety, and depression with inflammation processes in several diseases (such as coronary heart patients and cancer) (10,15,16). However, few studies have been performed on the potential cognition impairment/anxiety/depression-associated inflammatory cytokines in AIS patients.…”

Section: Discussionmentioning

confidence: 99%

Correlation of common inflammatory cytokines with cognition impairment, anxiety, and depression in acute ischemic stroke patients

Fan

et al. 2022

Braz J Med Biol Res

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Inflammatory cytokines are related to cognitive function and psychiatric disorders in patients with several diseases. However, few relevant studies have been performed on acute ischemic stroke (AIS) patients. Hence, this study aimed to investigate the correlation of common inflammatory cytokines with cognition impairment, anxiety, and depression in AIS patients. Common inflammatory cytokines of 176 AIS patients (including tumor necrosis factor-alpha (TNF-a), interleukin (IL)-1b, IL-6, and IL-17) were measured using Human Enzyme Linked Immunosorbent Assay Kits. Cognition impairment (Mini-Mental State Examination (MMSE)), anxiety (Hospital Anxiety and Depression Scale for anxiety (HADS-A)), and depression (HADS-D) were evaluated. The incidence of cognition impairment, anxiety, and depression was 43.2, 39.2, and 31.2%, respectively. TNF-a and IL-6 were negatively associated with MMSE score, and high TNF-a, IL-1b, and IL-6 were correlated with cognition impairment occurrence. In addition, TNF-a, IL-1b, and IL-17 were positively associated with HADS-A score, while only high TNF-a was associated with anxiety occurrence. Furthermore, TNF-a, IL-1b, and IL-17 were positively associated with HADS-D score, while high IL-1b, IL-6, and IL-17 correlated with depression occurrence. Multivariate logistic regression revealed that TNF-a and National Institutes of Health Stroke Scale (NIHSS) score X5 were associated with high risk of cognition impairment; TNF-a, IL-17, unemployed before surgery, hypertension, and chronic kidney disease (CKD) correlated with high anxiety occurrence. Furthermore, IL-17, divorced/widowed/single status, diabetes, and NIHSS score X5 were associated with high risk of depression. In conclusion, common inflammatory cytokines including TNF-a, IL-1b, and IL-17 were related to cognition impairment, anxiety, or depression in AIS patients.

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“…In this regard, brain tumors can trigger robust local inflammatory responses [ 31 , 32 ]. Systemic elevation of inflammatory markers has also been linked with worsening prognosis in patients with brain tumors [ 33 , 34 ]. Therefore, the presence of these inflammatory mediators in the circulation and cerebrospinal fluid (CSF) might potentiate the risk for suicidality as they have been convincingly shown to be positive correlates of SI.…”

Section: Discussionmentioning

confidence: 99%

Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar

et al. 2020

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Background: Suicidality and brain tumors are two life-threatening conditions and, somewhat unexpectedly, the associations between them have scarcely been reported. Objective: In this study, we aimed to provide a brief literature review of epidemiological studies on suicidal ideation (SI) and suicidal behavior (SB) in patients with brain tumors. To illustrate various aspects of brain tumors that potentially underlie the emergence of suicidality, the review is supplemented with a clinical exemplar of a long-term survivor of brain tumor (glioblastoma) who experienced persistent SI. Furthermore, we discuss putative both neurobiological (including anatomical and immunological) and psychosocial mechanisms that might be accountable for the development of SI and SB in patients with brain tumors. Conclusions: While the etiology of this phenomenon appears to be multifactorial and still remains a subject of much debate, it is of critical importance to identify patients for which a psychiatric evaluation could recognize, in a timely manner, a possible suicide risk and alleviate the deep related suffering, by appropriate psychopharmacological and supportive and psychotherapeutic interventions.

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Inflammation and behavioral symptoms in preoperational glioma patients: Is depression, anxiety, and cognitive impairment related to markers of systemic inflammation?

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 23 publications

References 33 publications

Flare‑up of cytokines in rheumatoid arthritis and their role in triggering depression: Shared common function and their possible applications in treatment (Review)

Flare‑up of cytokines in rheumatoid arthritis and their role in triggering depression: Shared common function and their possible applications in treatment (Review)

Correlation of common inflammatory cytokines with cognition impairment, anxiety, and depression in acute ischemic stroke patients

Suicidality in Patients with Brain Tumors: A Brief Literature Review with Clinical Exemplar

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