Inflammation and Cardiovascular Diseases: The Most Recent Findings

Sorriento, Daniela; Iaccarino, Guido

doi:10.3390/ijms20163879

Cited by 135 publications

(88 citation statements)

References 19 publications

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“…It is known that competitive athletes are often affected by respiratory diseases or skin infections [43,44]. In addition, cardiovascular diseases can also be monitored through CRP [37][38][39][42][43][44][45][46]. Our data show that athletes have an increase in CRP values with an increase in physical activity.…”

Section: Discussionmentioning

confidence: 55%

“…Monitoring its levels helps determine disease progress and therapeutic efficacy. Furthermore, damage to the walls of the vessels can be caused by infiltration into the cell wall and inflammatory elements, for this reason, CRP levels can be used to establish the level of risk of cardiovascular disease [38,39] and its increase could also highlight the presence of genetic pathologies [39][40][41][42][43].…”

Section: Introductionmentioning

confidence: 99%

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Athlete’s Passport: Prevention of Infections, Inflammations, Injuries and Cardiovascular Diseases

Mennitti

Brancaccio

Gentile

et al. 2020

JCM

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Laboratory medicine in sports medicine is taking on an ever-greater role in the assessment and monitoring of an athlete’s health condition. The acute or intense exercise practiced by elite athletes can lead to the appearance of infections, inflammations, muscle injuries or cardiovascular disorders, whose diagnosis is not always rapid and efficient, as there is no continuous monitoring of the athlete. The absence of such monitoring can have serious consequences in terms of recovery of the professional athlete. These imbalances can induce metabolic adaptations which translate into alterations of specific parameters in terms of concentration and activity. The aim of this study was to follow the variation of specific biochemical biomarkers in a basketball team participating to the maximum championship during different phases of the agonistic season. The evaluation of serum biomarkers can help doctors to safeguard the athlete’s health and sports trainers to adapt workouts, thus avoiding the appearance of diseases and injuries that in some cases can be underestimated by becoming irreversible ailments that do not allow the athlete to return to a healthy state. This information can be useful to create athlete biologic passports.

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Section: Discussionmentioning

confidence: 55%

Section: Introductionmentioning

confidence: 99%

Athlete’s Passport: Prevention of Infections, Inflammations, Injuries and Cardiovascular Diseases

Mennitti

Brancaccio

Gentile

et al. 2020

JCM

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“…Inflammation exerts a key role in cardiovascular diseases, as extensively reported in the literature [37,38]. Inflammatory responses exert a different effect in the acute and chronic phase.…”

Section: Inflammationmentioning

confidence: 90%

The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction

Bellis¹,

Mauro

Barbato³

et al. 2020

Cells

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During the last three decades, timely myocardial reperfusion using either thrombolytic therapy or primary percutaneous intervention (pPCI) has allowed amazing improvements in outcomes with a more than halving in 1-year ST-elevation myocardial infarction (STEMI) mortality. However, mortality and left ventricle (LV) remodeling remain substantial in these patients. As such, novel therapeutic interventions are required to reduce myocardial infarction size, preserve LV systolic function, and improve survival in reperfused-STEMI patients. Myocardial ischemia-reperfusion injury (MIRI) prevention represents the main goal to reach in order to reduce STEMI mortality. There is currently no effective therapy for MIRI prevention in STEMI patients. A significant reason for the weak and inconsistent results obtained in this field may be the presence of multiple, partially redundant, mechanisms of cell death during ischemia-reperfusion, whose relative importance may depend on the conditions. Therefore, it is always more recognized that it is important to consider a “multi-targeted cardioprotective therapy”, defined as an additive or synergistic cardioprotective agents or interventions directed to distinct targets with different timing of application (before, during, or after pPCI). Given that some neprilysin (NEP) substrates (natriuretic peptides, angiotensin II, bradykinin, apelins, substance P, and adrenomedullin) exert a cardioprotective effect against ischemia-reperfusion injury, it is conceivable that antagonism of proteolytic activity by this enzyme may be considered in a multi-targeted strategy for MIRI prevention. In this review, by starting from main pathophysiological mechanisms promoting MIRI, we discuss cardioprotective effects of NEP substrates and the potential benefit of NEP pharmacological inhibition in MIRI prevention.

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“…Recent studies have proposed a key role of inflammation in the determination of cardiovascular risk [28]. Levels of inflammatory cytokines are elevated in HF patients and related to an adverse outcome [29].…”

Section: Discussionmentioning

confidence: 99%

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

Lanser

Pölzl

Fuchs

et al. 2019

JCM

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Inflammation and immune activation play an important role in the pathogenesis of cardiac remodelling in patients with heart failure. The aim of this study was to assess whether biomarkers of inflammation and immune activation are linked to disease severity and the prognosis of heart failure patients. In 149 patients (65.8% men, median age 49.7 years) with heart failure from nonischaemic cardiomyopathy, the biomarkers neopterin and C-reactive protein were tested at the time of diagnosis. Patients were followed-up for a median of 58 months. During follow-up, nineteen patients died, five had a heart transplantation, two needed a ventricular assistance device, and twenty-one patients had to be hospitalised because of heart failure decompensation. Neopterin concentrations correlated with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) concentrations (rs = 0.399, p < 0.001) and rose with higher New York Heart Association (NYHA) class (I: 5.60 nmol/L, II: 6.90 nmol/L, III/IV: 7.80 nmol/L, p = 0.033). Higher neopterin levels were predictive for an adverse outcome (death or hospitalisation due to HF decompensation), independently of age and sex and of established predictors in heart failure such as NYHA class, NT-proBNP, estimated glomerular filtration rate (eGFR), and left ventricular ejection fraction (LV-EF) (HR 2.770; 95% CI 1.419–5.407; p = 0.003). Patients with a neopterin/eGFR ratio ≥ 0.133 (as a combined marker for immune activation and kidney function) had a more than eightfold increased risk of reaching an endpoint compared to patients with a neopterin/eGFR ratio ≤0.065 (HR 8.380; 95% CI 2.889–24.308; p < 0.001). Neopterin is associated with disease severity and is an independent predictor of prognosis in patients with heart failure.

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Inflammation and Cardiovascular Diseases: The Most Recent Findings

Cited by 135 publications

References 19 publications

Athlete’s Passport: Prevention of Infections, Inflammations, Injuries and Cardiovascular Diseases

Athlete’s Passport: Prevention of Infections, Inflammations, Injuries and Cardiovascular Diseases

The Rationale of Neprilysin Inhibition in Prevention of Myocardial Ischemia-Reperfusion Injury during ST-Elevation Myocardial Infarction

Neopterin is Associated with Disease Severity and Outcome in Patients with Non-Ischaemic Heart Failure

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