Inflammation and Immune Response in COPD: Where Do We Stand?

Rovina, Nikoletta; Koutsoukou, Antonia; Koulouris, Nikolaos

doi:10.1155/2013/413735

Cited by 192 publications

(175 citation statements)

References 105 publications

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“…The mechanism of COPD in RA has been suggested by prior studies to be autoimmune or inflammatory, with cytokines and chemokines contributing to lung tissue destruction [1,8,9]. Studies looking at association of reduced lung function tests with systemic inflammatory markers have shown that COPD patients have higher levels of circulating inflammatory markers including leukocytes, fibrinogen, ESR, CRP, tumor necrosis factor-α, suggesting that systemic inflammation may have a role in COPD [11].…”

Section: Discussionmentioning

confidence: 99%

“…Studies have been carried out in various regions of the world- Canada, Israel, Taiwan, Netherlands, Sweden and Minnesota, all suggesting that COPD is more prevalent in RA [2–7]. Although smoking is known to be a major risk factor for development and progression of COPD, the presence of substantial number of COPD patients who have never smoked suggests that other factors may play a role, with inflammatory and immune responses being important ones [8,9]. We aimed to explore this relationship in an inpatient setting, using a large inpatient database.…”

Section: Introductionmentioning

confidence: 99%

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Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Dhital

Basnet

Paudel

et al. 2018

Journal of Community Hospital Internal Medicine Perspectives

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Rheumatoid arthritis (RA) is being increasingly recognized as an important contributor to chronic obstructive pulmonary disease (COPD). Although smoking is a major risk factor, other factors may play a role. We used National Inpatient Sample (NIS) from 2013 to explore this relationship. We used propensity matching with a 1:3 nearest-neighbor-matching algorithm to match 1 RA hospitalization to 3 age- and-sex-matched comparators. In the age- and-sex-matched population, RA had a higher odds of COPD (OR 1.20, 95% CI: 1.17–1.22, p < 0.0001).RA is associated with increased COPD prevalence, independent of smoking. COPD might fall within the spectrum of RA complications, likely due to autoimmune and inflammatory mechanisms.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Dhital

Basnet

Paudel

et al. 2018

Journal of Community Hospital Internal Medicine Perspectives

View full text Add to dashboard Cite

show abstract

“…Increasing evidence indicates that chronic inflammatory and immune responses play key roles in the development and progression of smokingrelated disorders [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

“…The inflammatory response associated with tobacco smoking is characterised by an array of dysregulated cells, cytokines, and growth factors that are described as being conducive to the development of COPD, CVD and lung cancer via several possible pathways [5,23,24].…”

Section: Introductionmentioning

confidence: 99%

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

Andreoli¹,

Bassi²,

Gregg³

et al. 2015

Clinical Chemistry and Laboratory Medicine (CCLM)

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Background: Despite the well-documented role of cigarette smoke in the development of chronic obstructive pulmonary disease (COPD), lung cancer and cardiovascular disease, biomarkers for screening or monitoring disease progression and outcome remain elusive, particularly for COPD and lung cancer. Inflammatory cells and mediators are likely to be involved in the disease processes, but their importance is still poorly understood. The purpose of this study was to investigate early changes in immunological markers associated with smoking in healthy monozygotic twins without a detectable disease discordant for smoking, thereby minimising data variability due to genetic background. Methods: Twenty-two monozygotic twin pairs, aged 31.5 ± 6.3 years, entered the study. One of each twin pair was a smoker and the other a non-smoker. None of the subjects reported any diseases or clinically defined respiratory symptoms or airflow limitation. Each subject donated blood samples for determination of total leukocytes and subpopulations, lymphocyte subpopulation plus pro-inflammatory mediators (interleukin-8, tumour necrosis factor-α, soluble tumour necrosis factor-α receptors and C-reactive protein). Results: We observed a significant increase in the number of circulating leukocytes and neutrophils in smokers compared to non-smokers. Smokers also had significantly higher numbers of B cells and CD4 + T cells, plus an increased CD4/CD8 ratio. The numbers of NK cells were statistically significant lower in smokers compared to non-smokers.

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“…IGHG1, or immunoglobulin heavy constant gamma 1 is considered a true positive since immunity plays a central role in COPD (Rovina et al, 2013). Another gene identified as a hub is SARDH, or sarcosine dehydrogenase which has been implicated previously in COPD (Ubhi et al, 2012).…”

Section: Known and Novel Targetsmentioning

confidence: 99%

The discordant method: a novel approach for differential correlation

2015

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Motivation: Current differential correlation methods are designed to determine molecular feature pairs that have the largest magnitude of difference between correlation coefficients. These methods do not easily capture molecular feature pairs that experience no correlation in one group but correlation in another, which may reflect certain types of biological interactions. We have developed a tool, the Discordant method, which categorizes the correlation types for each group to make this possible. Results: We compare the Discordant method to existing approaches using simulations and two biological datasets with different types of -omics data. In contrast to other methods, Discordant identifies phenotype-related features at a similar or higher rate while maintaining reasonable computational tractability and usability. Availability and implementation: R code and sample data are available at https://github.com/siskac/

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Inflammation and Immune Response in COPD: Where Do We Stand?

Cited by 192 publications

References 105 publications

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Prevalence of chronic obstructive pulmonary disease (COPD) among rheumatoid arthritis: results from national inpatient database

Effects of cigarette smoking on circulating leukocytes and plasma cytokines in monozygotic twins

The discordant method: a novel approach for differential correlation

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