Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer

Yao, Dianbo; Dong, Ming; Dai, Chaoliu; Wu, Shuodong

doi:10.1093/ibd/izz149

Cited by 228 publications

(165 citation statements)

References 74 publications

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“…28 Chronic inflammation can lead to repeated stimulation of epithelial cells and infiltration of immune cells and soluble mediators, which provides an ideal microenvironment for tumor development. 29 The anti-inflammatory effect of miR-370-3p in vitro and in vivo has been widely reported, 10,30,31 which was in line with our findings. TNF-α signaling promotes the expression of downstream inflammatory mediators associated with abnormal cell proliferation and differentiation.…”

Section: Discussionsupporting

confidence: 91%

miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition

Lin¹,

Wang²,

Qu³

et al. 2020

DDDT

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Introduction: Ulcerative colitis (UC) is a chronic and inflammatory bowel disease. UCassociated colorectal cancer (UC-CRC) is one of the most severe complications of long-standing UC. In the present study, we explored the effects of miR-370-3p on UC-CRC in vivo and investigated its underlying mechanisms in vivo and in vitro. Methods: Azoxymethane (AOM) and dextran sodium sulfate (DSS) were used to induce UC-CRC in C57BL/6 mice. AOM/DSS-induced mice were treated with 5×10 8 pfu miR-370-3p overexpressing-adenovirus via tail-vein injection every two weeks. Results: We found that miR-370-3p significantly improved the body weights and survival rates and inhibited the tumorigenesis of UC-CRC in AOM/DSS mice. Mechanically, miR-370-3p inhibited AOM/DSS-induced inflammatory response by decreasing tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) through targeting toll-like receptor 4 (TLR4), as demonstrated by down-regulation of TLR4, cyclooxygenase-2 (COX-2), prostaglandin E2 (PGE2), and phosphorylated epidermal growth factor receptor (pEGFR). miR-370-3p decreased the expression of tumor-associated proteins, including p53, β-catenin, and ki67 in AOM/DSS-treated mice. Additionally, miR-370-3p remarkably inhibited epithelialmesenchymal transition (EMT) via increasing E-cadherin expression and reducing N-cadherin and Vimentin expression in vivo. Further studies showed that miR-370-3p repressed proliferation and EMT of colon cancer cells in vitro. Moreover, we proved that miR-370-3p decreased the expression of tumor-associated proteins and reversed EMT by regulating β-catenin in colon cancer cells. Conclusion: Taken together, miR-370-3p alleviated UC-CRC by inhibiting the inflammatory response and EMT in mice, which suggested miR-370-3p as a novel potential target for UC-CRC therapy.

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Section: Discussionsupporting

confidence: 91%

miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition

Lin¹,

Wang²,

Qu³

et al. 2020

DDDT

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“…69 Overproduction of ROS and consequent inflammation of the mucosa are the important causes of tissue injury in UC. 70 Recent studies have found that some peptide hormones may have a healing effect on UC. For instance, the anti-inflammatory effect of ghrelin is demonstrated in various types of chronic inflammation, including UC.…”

Section: Intestinal Diseasesmentioning

confidence: 99%

Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review

Xu¹,

Chen²

2020

JIR

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Nesfatin-1, a newly identified energy-regulating peptide, is widely expressed in the central and peripheral tissues, and has a variety of physiological activities. A large number of recent studies have shown that nesfatin-1 exhibits antioxidant, antiinflammatory, and anti-apoptotic properties and is involved in the occurrence and progression of various diseases. This review summarizes current data focusing on the therapeutic effects of nesfatin-1 under different pathophysiological conditions and the mechanisms underlying its antioxidant, anti-inflammatory, and anti-apoptotic activities.

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“…A combination of genetic, environmental and immunological factors seems to contribute to the onset of the disease and several molecular mechanisms have been proposed to understand the pathogenesis and progress of the disease. Suppression of mitochondrial genes and function [ 13 ], disruption of the intestinal mucosal barrier and bacterial invasion resulting in intestinal inflammation, and further TLR4/NF-κB stimulation in intestinal epithelial cells are some of the proposed mechanisms [ 14 ]. The role of intestinal microbiota has also been investigated and there seems to be evidence on differences in the intestinal microbial metabolism between healthy and patients with IBD [ 15 ] as well as on the involvement of bacterial sulfate metabolism in gut inflammation [ 16 , 17 , 18 ] More specifically, sulphate reducing bacteria use sulfate as an electron acceptor in dissimilatory sulfate reduction and the final product is H2S, a potential toxic, mutagenic and cancerogenic compound [ 19 ].…”

Section: Discussionmentioning

confidence: 99%

The Association of Plasma-Free Branched-Chain Amino Acids with Disease Related Parameters in Ulcerative Colitis

et al. 2020

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Branched-chain amino acids (BCAAs) are involved in immune system’s metabolic pathways and play fundamental role in gut health. Our aim was to assess BCAA plasma levels in patients with ulcerative colitis (UC) and associations of plasma BCAAs with disease-related parameters. This was a case-control study in adult patients with UC and BMI-matched controls. A total of 150 volunteers were screened between May 2016 and June 2017; 43 patients and 34 healthy controls were enrolled. Medical and dietary history (3 × 24 h recalls, MedDiet score), anthropometric measurements, blood and fecal samples were collected. We measured BCAAs in plasma with gas chromatography-mass spectrometry. In patients, fecal calprotectin, lactoferrin, lysozyme and defensin were quantified. Dietary pattern was similar in patients and controls. Plasma-free BCAA profiles did not differ between groups. Regression analysis showed that i) valine was inversely associated with calprotectin (p = 0.007) and ii) isoleucine with age (p = 0.031), after adjusting for age, sex, PMS and smoking. Leucine was negatively associated with age (p = 0.015) after adjusting for age, sex and PMS, but this association vanished when smoking was introduced. No correlation was observed between total BCAAs with any of the parameters. Plasma-free valine is negatively associated with calprotectin in patients with UC.

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Inflammation and Inflammatory Cytokine Contribute to the Initiation and Development of Ulcerative Colitis and Its Associated Cancer

Cited by 228 publications

References 74 publications

<p>miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition</p>

<p>miR-370-3p Alleviates Ulcerative Colitis-Related Colorectal Cancer in Mice Through Inhibiting the Inflammatory Response and Epithelial-Mesenchymal Transition</p>

<p>Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of Nesfatin-1: A Review</p>

The Association of Plasma-Free Branched-Chain Amino Acids with Disease Related Parameters in Ulcerative Colitis

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