Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

Spielman, Lindsay Joy; Little, Jonathan P.; Klegeris, Andis

doi:10.1016/j.jneuroim.2014.06.004

Cited by 154 publications

(105 citation statements)

References 229 publications

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“…It is intricately linked to a number of major diseases including cancer, diabetes, cardiovascular disease, and neurological disorders (69,70). In the present study we sought to identify kinases that act as co-regulators of the insulin/IGF-1 pathway.…”

Section: Discussionmentioning

confidence: 99%

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

Trefely

Khoo

Krycer

et al. 2015

Journal of Biological Chemistry

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Background: Insulin regulates metabolism via the PI3K/Akt pathway. Results: A kinome siRNA screen identified PFKFB3, a glycolysis regulator, as a modulator of insulin action. Manipulation of PFKFB3 activity or glycolysis affected insulin signaling. Conclusion: Intracellular metabolism modulates important signal transduction pathways. Significance: The novel link between glycolysis and growth factor signaling has important implications for the treatment of metabolic diseases.

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Section: Discussionmentioning

confidence: 99%

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

Trefely

Khoo

Krycer

et al. 2015

Journal of Biological Chemistry

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“…For example, several lifestyle-related conditions, including obesity, type 2 diabetes mellitus (T2DM), and lack of PA, are accompanied by chronic activation of the immune system, which leads to a systemic proinflammatory state (Spielman et al, 2014;Tucsek et al, 2014). PA and exercise have the potential to reduce and revert some of the immune activation associated with these behaviors, returning the body to a healthy state (Gaesser, 2007).…”

Section: Anti-inflammatory Effects Of Physical Activity and Exercise mentioning

confidence: 99%

Physical activity and exercise attenuate neuroinflammation in neurological diseases

Spielman

Little

Klegeris

2016

Brain Research Bulletin

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“…pathologies including Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease, major depressive disorder (MDD) and schizophrenia (see Table 1 and a review by Spielman et al, 2014 [39] ).…”

Section: Major Depressive Disordermentioning

confidence: 99%

The Role of Insulin and Incretins in Neuroinflammation and Neurodegeneration

2015

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Glucagon-like peptide 1 (GLP-1) and glucose-dependent insulinotrophic polypeptide (GIP) are incretin hormones secreted from intestinal cells in response to incoming nutrients. The release of these incretins triggers the production and secretion of insulin from pancreatic β cells, which upregulates the transport of glucose from the blood stream into the muscles, liver and adipose tissue for storage; therefore, insulin and incretins are vital to maintaining energy homeostasis within the body. Recently, it has been recognized that the activity of these hormones is not limited to the periphery, but extends to the central nervous system (CNS) as well. Within the CNS, insulin and incretins function as components of the anti-apoptotic and growth-regulating signaling cascades. Moreover, anti-inflammatory and neuroprotective roles for these hormones in the CNS have also been demonstrated. Specific discoveries have been made suggesting that insulin, GLP-1 and GIP may inhibit pathological processes in several CNS diseases, such as Alzheimer's disease, Parkinson's disease, and schizophrenia.

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Inflammation and insulin/IGF-1 resistance as the possible link between obesity and neurodegeneration

Cited by 154 publications

References 229 publications

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

Kinome Screen Identifies PFKFB3 and Glucose Metabolism as Important Regulators of the Insulin/Insulin-like Growth Factor (IGF)-1 Signaling Pathway

Physical activity and exercise attenuate neuroinflammation in neurological diseases

The Role of Insulin and Incretins in Neuroinflammation and Neurodegeneration

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