Inflammation and Insulin Resistance

Bloomgarden, Zachary T.

doi:10.2337/diacare.26.6.1922

Cited by 87 publications

(35 citation statements)

References 54 publications

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“…Obesity is commonly characterized by inflammation in liver and adipose tissue, which is associated with various diseases including insulin resistance, diabetes, and atherosclerosis. Inflammatory cytokines (e.g., TNFα, MCP-1, and IL-6) inhibit insulin signaling and lipid homeostasis in mice [27]. In our study, mRNA levels of inflammatory cytokines were significantly decreased in α-MG-treated obese mice, suggesting that reducing inflammation in liver and adipose tissue induces insulin signaling, which could improve the inflammation of liver and adipose tissue.…”

Section: Discussionmentioning

confidence: 54%

α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2

Kim

Huh

et al. 2017

PLoS ONE

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Obesity induces various metabolic diseases such as dyslipidemia, nonalcoholic fatty liver disease (NAFLD), and type 2 diabetes. Fat expansion in adipose tissue induces adipose tissue dysfunction and inflammation, insulin resistance, and other metabolic syndromes. α-Mangostin (α-MG) has been previously studied for its anti-cancer, anti-inflammatory, and antioxidant activities. In this study, we investigated the effects of α-MG on adipose tissue inflammation and hepatic steatosis. We categorized study animals into four groups: regular diet control mice, RD mice treated with α-MG, high fat diet-induced obese mice, and HFD mice treated with α-MG. α-MG treatment significantly reduced not only the body, liver, and fat weights, but also plasma glucose, insulin, and triglyceride levels in HFD mice. Additionally, adiponectin levels of α-MG-treated mice were significantly higher than those of control HFD mice. Immunohistochemistry of liver and adipose tissue showed that CD11c expression was reduced in α-MG fed obese mice. α-MG treatment of HFD mice down-regulated the adipose-associated inflammatory cytokines and CCR2 in both liver and adipose tissue. Moreover, glucose tolerance and insulin sensitivity were significantly improved in α-MG fed obese mice. α-Mangostin ameliorates adipose inflammation and hepatic steatosis in HFD-induced obese mice.

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Section: Discussionmentioning

confidence: 54%

α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2

Kim

Huh

et al. 2017

PLoS ONE

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“…Uncontrolled diabetes can lead to various complications including increased susceptibility to infections [57] such as TB and HIV. In turn, these infections can worsen glycaemic control [58] and therefore impact negatively on diabetes management.…”

Section: Resultsmentioning

confidence: 99%

Challenges in diabetes management in Indonesia: a literature review

2013

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Background and objectivesThe expanding diabetes epidemic worldwide could have potentially devastating effects on the development of healthcare systems and economies in emerging countries, both in terms of direct health care costs and loss of working time and disability. This study aims to review evidence on the burden, expenditure, complications, treatment, and outcomes of diabetes in Indonesia and its implications on the current health system developments.MethodsWe conducted a comprehensive literature review together with a review of unpublished data from the Ministry of Health and a public health insurer (Askes). Studies presenting evidence on prevalence, incidence, mortality, costs, complications and cost of complications, treatment, and outcomes were included in the analysis.ResultsA limited number of international, national and local studies on the burden and cost of diabetes in Indonesia were identified. National survey data suggests that in 2007 the prevalence of diabetes was 5.7%, of which more than 70% of cases were undiagnosed. This estimate hides large intracountry variation. There was very limited data available on direct costs and no data on indirect costs. The most commonly-identified complication was diabetic neuropathy.DiscussionThere were a number of limitations in the data retrieved including the paucity of data representative at the national level, lack of a clear reference date, lack of data from primary care, and lack of data from certain regions of the country.ConclusionsIf left unaddressed, the growing prevalence of diabetes in the country will pose a tremendous challenge to the Indonesian healthcare system, particularly in view of the Government’s 2010 mandate to achieve universal health coverage by 2014. Essential steps to address this issue would include: placing diabetes and non-communicable diseases high on the Government agenda and creating a national plan; identifying disparities and priority areas for Indonesia; developing a framework for coordinated actions between all relevant stakeholders.

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“…In addition, the synthesis of proinflammatory cytokines occurs in several types of renal cells (glomerular, endothelial, tubular and mesangial), as well as in monocytes, macrophages and T cells [20]. Accumulating evidence also suggests that individuals who progress to diabetes display features of inflammation years before the onset of the disease [21], and population-based studies indicate that inflammatory parameters are strong predictors of the development of diabetes [22]. …”

Section: Introductionmentioning

confidence: 99%

A systematic review and meta-analysis of genetic association studies for the role of inflammation and the immune system in diabetic nephropathy

Tziastoudi

Stefanidis

Hadjigeorgiou

et al. 2017

Clinical Kidney Journal

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Background: Despite the certain contribution of metabolic and haemodynamic factors in diabetic nephropathy (DN), many lines of evidence highlight the role of immunologic and inflammatory mechanisms. To elucidate the contribution of the immune system in the development of DN, we explored the contribution of gene variants (polymorphisms) in relevant pathophysiologic pathways. Methods: We selected six major pathways related to immune response from the Kyoto Encyclopaedia of Genes and Genomes database and thereafter we traced all available genetic association studies (GASs) involving gene variants in these pathways from PubMed and HuGE Navigator. Finally, we used meta-analytic methods for synthesizing the results of the GASs. Results: One hundred three GASs were retrieved that included 443 variants from 75 genes. Of those variants, 138 were meta-analysed and 61 produced significant results; seven variants were investigated in single GASs and showed significant association. Variants in CCL2, CCR5, IL6, IL8, EPO, IL1A, IL1B, IL100, IL1RN, GHRL, MMP9, TGFB1, VEGFA, MMP3, MMP12, IL12RB1, PRKCE, TNF and TNFRSF19 genes were associated with an increased risk of DN. Conclusions: There is evidence that variants related with immunologic response affect the course of DN. However, the present results should be interpreted with caution since the current number of available GASs is limited.

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Inflammation and Insulin Resistance

Cited by 87 publications

References 54 publications

α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2

α-Mangostin ameliorates hepatic steatosis and insulin resistance by inhibition C-C chemokine receptor 2

Challenges in diabetes management in Indonesia: a literature review

A systematic review and meta-analysis of genetic association studies for the role of inflammation and the immune system in diabetic nephropathy

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