Inflammation and nutritional status as predictors of physical performance and strength loss during hospitalization

Rossi, Andrea P.; Zanandrea, Valeria; Zoico, Elena; Zanardo, Marina; Caliari, Cesare; Confente, Silvia; Gabriele, Sara; Mazzali, Gloria; Fantin, Francesco; Zamboni, Mauro

doi:10.1038/ejcn.2016.159

Cited by 20 publications

(17 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Several studies have explored the triad of disease/injury, systemic inflammation, and malnourishment. The stress released by disease/injury and metabolism and comorbidities altered by the inflammatory response and malnourishment make the triad highly associated with risk of mortality . One plausible mechanism through which EN may mitigate inflammation is via interactions with the gut‐associated lymphoid tissue (GALT).…”

Section: Discussionmentioning

confidence: 99%

“…A total of 161 patients with available F-NLR was included in the analysis; 68% were male, with a median age of 62 (range, 52-72) years and a median BMI of 27 (range, [23][24][25][26][27][28][29][30]. Details are listed in Table 1.…”

Section: Baselinementioning

confidence: 99%

“…The stress released by disease/injury and metabolism and comorbidities altered by the inflammatory response and malnourishment make the triad highly associated with risk of mortality. 8,21,[27][28][29] One plausible mechanism through which EN may mitigate inflammation is via interactions with the gut-associated lymphoid tissue (GALT). Xi et al demonstrated that prolonged fasting and delayed EN initiation in critically ill patients increases the inflammatory response.…”

Section: Nlr As a Clinical Biomarkermentioning

confidence: 99%

See 2 more Smart Citations

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Baselinementioning

confidence: 99%

Section: Nlr As a Clinical Biomarkermentioning

confidence: 99%

See 1 more Smart Citation

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Patients' height and weight were recorded at the beginning of hospitalization as previously reported [15].…”

Section: Anthropometric Measuresmentioning

confidence: 99%

Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid-19 related respiratory failure: clinical relevance and potential pathophysiological mechanism.

Rossi

Gottin

Donadello

et al. 2020

Preprint

View full text Add to dashboard Cite

Abstract Background/Objectives: Recent studies show that obesity is a risk factor for hospital admission and for critical care need in patients with coronavirus disease 2019 (COVID-19).The aim was to determine whether obesity is a risk factor for unfavourable health outcomes in patients affected by COVID-19 admitted to ICU and to compare the observed trend of C-Reactive Protein (CRP) and Creatine Phosphokinase (CPK), as potential pathophysiological mechanisms linking disease severity with Body Mass Index (BMI).Subjects/Methods: 95 consecutive patients with COVID-19 (78 males and 18 females) were admitted to ICU and included in the study. Height, weight, BMI, Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) scores, CRP, CPK, as well as ICU and hospital length of stay and comorbidities were evaluated. Results: Participants with obesity had a lower 28 day survival rate from ICU admission than normal weight subjects. Cox proportional hazard model-derived estimates, adjusted for age, gender and comorbidity, confirmed the results of the survival analysis (HR:5.30,95%C.I.1.26-22.34). In the full adjusted model, age was independently associated with mortality (HR:1.13,95%C.I:1.05-1.21).Obese subjects showed longer hospital and ICU stay as compared with normal weight counterpart.Subjects with obesity showed significantly higher CRP and CPK levels than normal weight subjects.Conclusions: Our study shows that in COVID-19 subjects admitted to ICU obesity is a risk factor for unfavourable health outcomes with higher mortality and longer hospital stay. The increase in CRP and CPK levels observed in this population could at least in part explain the unfavourable outcomes observed in individuals with obesity. In those subjects, careful management of any medical signs or symptoms and prompt intervention in case of suspected SARS-CoV-2 infection is necessary to prevent the progression of the disease towards severe outcomes and the increase of hospital treatment costs.

show abstract

“…Growing evidence suggested a direct role of circulating pro-inflammatory cytokines in the deterioration of physical performance with a direct effect on the imbalance between protein anabolism and catabolism [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Hospitalization Effects on Physical Performance and Muscle Strength in Hospitalized Elderly Subjects

Rossi¹,

Rubele²,

Amodio³

et al. 2017

J Gerontol Geriatr Res

View full text Add to dashboard Cite

show abstract

Inflammation and nutritional status as predictors of physical performance and strength loss during hospitalization

Abstract: Simultaneous presence of high CRP values and malnutrition determines an additive effect on muscle strength loss and physical performance.

Cited by 20 publications

References 9 publications

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

Early Enteral Nutrition Adequacy Mitigates the Neutrophil–Lymphocyte Ratio Improving Clinical Outcomes in Critically Ill Surgical Patients

Obesity as a risk factor for unfavourable outcomes in critically ill patients affected by Covid-19 related respiratory failure: clinical relevance and potential pathophysiological mechanism.

Hospitalization Effects on Physical Performance and Muscle Strength in Hospitalized Elderly Subjects

Contact Info

Product

Resources

About