Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome

Ertuğlu, Lale A.; Mutchler, Ashley Pitzer; Yu, Justin D.; Kirabo, Annet

doi:10.3389/fphys.2022.1096296

Cited by 26 publications

(17 citation statements)

References 153 publications

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“…The rationale behind the purported activities of omega 3 fatty acids on the endothelium and vasomotion is manifold. For example, omega 3 fatty acids are anti-inflammatory molecules [ 136 ] and inflammation greatly participates in the development of, e.g., arterial stiffness [ 117 ], impaired vasomotion [ 137 ], and hypertension [ 138 ]. Moreover, that are — paradoxically — anti- rather than pro-oxidant [ 139 , 140 ], via molecular mechanisms that have been largely elucidated and include, e.g., inhibition of NADPH oxidase 4 (Nox 4), V sPLA 2 , and cyclooxygenases, as well as reduced superoxide production [ 140 ], thereby maintaining an adequate “peroxide tone” [ 141 ].…”

Section: Methodsmentioning

confidence: 99%

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Tomé‐Carneiro

Visioli

2023

Curr Hypertens Rep

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Purpose of Review Accumulating data on the consumption of plant-based diets and their impact on blood pressure indicate a consensus that plant-based diets are linked to reduced blood pressure. The suggested mechanisms of action are manifold, and, in this systematic review, we provide a summary of the most recent findings on plant-based diets and their impact on blood pressure, along with an analysis of the molecules accountable for the observed effects. Recent Findings The overwhelming majority of intervention studies demonstrate that plant-based diets result in lower blood pressure readings when compared to diets that are based on animal products. The various mechanisms of action are being clarified. Summary The data discussed in this systematic review allow us to conclude that plant-based diets are associated with lower blood pressure and overall better health outcomes (namely, on the cardiovascular system) when compared to animal-based diets. The mechanisms of action are being actively investigated and involve many macro- and micronutrients plentiful in plants and the dishes prepared with them.

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Section: Methodsmentioning

confidence: 99%

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Tomé‐Carneiro

Visioli

2023

Curr Hypertens Rep

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“…RAAS is a critical regulator of blood pressure, and various components of the RAAS signalling pathway can directly impact immune cell function [60]. We recently investigated in-vitro expression of RAAS-related genes in human monocytes from healthy individuals in response to high sodium and found that expression of these genes did not correlate with salt-induced activation of myeloid immune cells in salt-sensitive hypertension [61]. These results suggest that RAAS may not play a significant role in regulating immune cell ENaC in SSBP.…”

Section: Regulation Of Immune Cell Epithelial Sodium Channelmentioning

confidence: 99%

“…Inflammasome activation is another recent discovery involved in the relationship between inflammation, autoimmunity, and SSBP [ 62 ]. Our group recently elucidated the role of NOD-like receptor family pyrin domain containing 3 (NLRP3) in SSBP [ 62 , 63 ▪▪ ] (Fig. 3 ).…”

Section: Downstream Signalling In Epithelial Sodium Channel Activated...mentioning

confidence: 99%

Dendritic cell epithelial sodium channel induced inflammation and salt-sensitive hypertension

Demirci,

Hinton,

Kirabo

2024

Current Opinion in Nephrology &Amp; Hypertension

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Purpose of review Salt sensitivity of blood pressure (SSBP) is an independent risk factor for cardiovascular disease. Epithelial sodium channel (ENaC) plays a critical role in renal electrolyte and volume regulation and has been implicated in the pathogenesis of SSBP. This review describes recent advances regarding the role of ENaC-dependent inflammation in the development of SSBP. Recent findings We recently found that sodium enters dendritic cells via ENaC, a process regulated by serum/glucocorticoid-regulated kinase 1 and epoxyeicosatrienoic acid 14,15. Sodium entry activates NADPH oxidase, leading to the production of isolevuglandins (IsoLGs). IsoLGs adduct self-proteins to form neoantigens in dendritic cells that activate T cells and result in the release of cytokines promoting sodium retention, kidney damage, and endothelial dysfunction in SSBP. Additionally, we described a novel mechanistic pathway involving ENaC and IsoLG-dependent NLRP3 inflammasome activation. These findings hold promise for the development of novel diagnostic biomarkers and therapeutic options for SSBP. Summary The exact mechanisms underlying SSBP remain elusive. Recent advances in understanding the extrarenal role of ENaC have opened a new perspective, and further research efforts should focus on understanding the link between ENaC, inflammation, and SSBP.

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“…Containing 3 (NLRP3) inflammasome, leading to the production of inflammatory cytokines such as tumor necrosis factor-alpha (TNF-α), IL-1β, and IL-6 [105,109,110]. The increased production of inflammatory cytokines coupled with the reduced production of NO resulting from ROS reactions leads to the stiffening of blood vessels and endothelial activation/dysfunction that contributes to hypertension and CVDs [109].…”

Section: Proposed Glycocalyx-salt Interaction Mechanisms Contributing...mentioning

confidence: 99%

Glycocalyx–Sodium Interaction in Vascular Endothelium

Sembajwe,

Ssekandi,

Namaganda

et al. 2023

Nutrients

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The glycocalyx generally covers almost all cellular surfaces, where it participates in mediating cell-surface interactions with the extracellular matrix as well as with intracellular signaling molecules. The endothelial glycocalyx that covers the luminal surface mediates the interactions of endothelial cells with materials flowing in the circulating blood, including blood cells. Cardiovascular diseases (CVD) remain a major cause of morbidity and mortality around the world. The cardiovascular risk factors start by causing endothelial cell dysfunction associated with destruction or irregular maintenance of the glycocalyx, which may culminate into a full-blown cardiovascular disease. The endothelial glycocalyx plays a crucial role in shielding the cell from excessive exposure and absorption of excessive salt, which can potentially cause damage to the endothelial cells and underlying tissues of the blood vessels. So, in this mini review/commentary, we delineate and provide a concise summary of the various components of the glycocalyx, their interaction with salt, and subsequent involvement in the cardiovascular disease process. We also highlight the major components of the glycocalyx that could be used as disease biomarkers or as drug targets in the management of cardiovascular diseases.

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Inflammation and oxidative stress in salt sensitive hypertension; The role of the NLRP3 inflammasome

Cited by 26 publications

References 153 publications

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Plant-Based Diets Reduce Blood Pressure: A Systematic Review of Recent Evidence

Dendritic cell epithelial sodium channel induced inflammation and salt-sensitive hypertension

Glycocalyx–Sodium Interaction in Vascular Endothelium

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