Inflammation and positive affect are associated with subjective health in women of the general population

Andréasson, Anna; Szulkin, Robert; Undén, Anna‐Lena; Essen, Jan von; Nilsson, Lars‐Göran; Lekander, Mats

doi:10.1177/1359105311435428

Cited by 39 publications

(46 citation statements)

References 39 publications

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“…These findings agree with those from cross-sectional studies linking SRH and low-grade systemic inflammation (e.g., Andreasson et al, 2013; Janszky et al, 2005; Lekander et al, 2004; Nakata, Takahashi, Otsuka, & Swanson, 2010). However, the present study extends these previous findings by demonstrating that the between-subject association was similar across up to 10 assessments over five years, which lends further weight to the link between SRH and inflammation.…”

Section: Discussionsupporting

confidence: 90%

“…Furthermore, cross-sectional associations can be driven by either stable or momentary relationships; this study indicates that such associations are due primarily to stable relationships. In addition, it adds evidence to the conclusion that the previously demonstrated relationship between SRH and inflammation in patient populations (Lekander et al, 2004; Janszky et al, 2005) and representative population samples (Andreasson et al, 2013) is not an artifact of poor control over disease or medication, since such relations should likely be captured by the medium time scale changes analyses presented in the current study.…”

Section: Discussionsupporting

confidence: 65%

“…Indeed, low-grade inflammation as measured by elevated levels of pro-inflammatory cytokines, especially interleukin-6 (IL-6), correlates with poorer SRH (Andreasson et al, 2013; Cohen, Pieper, Harris, Rao, & Currie, 1997; Janszky, Lekander, Blom, Georgiades, & Ahnve, 2005; Lekander, Elofsson, Neve, Hansson, & Undén, 2004). However, these cross-sectional findings cannot distinguish to what extent changes in SRH and inflammation are correlated within individuals over time.…”

Section: Introductionmentioning

confidence: 99%

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Self-rated health and interleukin-6: Longitudinal relationships in older adults

Arnberg

Lekander

Morey

et al. 2016

Brain, Behavior, and Immunity

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Background Both self-rated health (SRH) and inflammation are implicated in chronic diseases and premature mortality. Better SRH is associated with lower proinflammatory cytokines, but there is little evidence about whether this relationship is more stable or dynamic. Objective To study the between- and within-person associations between SRH and IL-6. Methods Older adults (N = 131; Mage = 75 years) rated their health and provided blood samples for analysis of IL-6 at separate occasions every 6 months over a period up to 5 years. Age, sex, BMI, neuroticism, and statin use were examined as covariates in multilevel models. Results In bivariate models, better SRH, lower BMI, younger age, and female sex correlated with lower IL-6. In multilevel models, stable SRH (between-person differences; p < .001) but not dynamic SRH (within-person changes; p = .93) correlated with IL-6. The stable relationship persisted with demographic and health covariates in the model. Conclusions Better stable SRH but not dynamic SRH was robustly associated with lower IL-6 among older adults, lending support to previous cross-sectional findings on the relation between inflammatory markers and SRH. The findings suggest that trait-like mechanisms, rather than changes over a time scale of 6-month waves, govern this association. To further investigate the mechanisms behind the SRH–IL-6 association, studies with different measurement frequencies, higher within-person variability, and experimental approaches are warranted.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 65%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Self-rated health and interleukin-6: Longitudinal relationships in older adults

Arnberg

Lekander

Morey

et al. 2016

Brain, Behavior, and Immunity

Self Cite

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“…However, the presence of low-grade inflammation may be an important determinant of individuals' subjective health. For example, a recent study from primary health care in Stockholm revealed that inflammatory cytokines were associated with poor subjective health, especially in participants over 65 years of age (Andreasson et al 2013). …”

Section: Introductionmentioning

confidence: 99%

Longitudinal trends in good self-rated health: effects of age and birth cohort in a 25-year follow-up study in Sweden

Johansson

Midlöv

Sundquist

et al. 2015

Int J Public Health

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“…In non-pregnant adults, several studies have examined associations between self-rated health and inflammation (12–19). For example, a study of 1,727 community-dwelling elderly adults found a graded association between a single-item measure of self-rated health and IL-6 (12).…”

Section: Introductionmentioning

confidence: 99%

Self-Rated Health among Pregnant Women: Associations with Objective Health Indicators, Psychological Functioning, and Serum Inflammatory Markers

et al. 2013

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Background Biobehavioral correlates of self-rated health in pregnancy are largely unknown. Purpose The goals of this study were to examine, in pregnant women, associations of self-rated health with 1) demographics, objective health status, health behaviors and psychological factors and 2) serum inflammatory markers. Methods In the 2nd trimester of pregnancy, 101 women provided a blood sample, completed measures of psychosocial stress, health status, and health behaviors, and received a comprehensive periodontal examination. Results The following independently predicted poorer self-rated health: 1) greater psychological stress, 2) greater objective health diagnoses, 3) higher body mass index, and 4) past smoking (versus never smoking). Poorer self-rated health was associated with higher serum interleukin-1β (p = .02) and marginally higher macrophage migration inhibitory factor (p = .06). These relationships were not fully accounted for by behavioral/psychological factors. Conclusions This study provides novel data regarding factors influencing subjective ratings of health and the association of self-rated health with serum inflammatory markers in pregnant women.

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Inflammation and positive affect are associated with subjective health in women of the general population

Cited by 39 publications

References 39 publications

Self-rated health and interleukin-6: Longitudinal relationships in older adults

Self-rated health and interleukin-6: Longitudinal relationships in older adults

Longitudinal trends in good self-rated health: effects of age and birth cohort in a 25-year follow-up study in Sweden

Self-Rated Health among Pregnant Women: Associations with Objective Health Indicators, Psychological Functioning, and Serum Inflammatory Markers

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