Inflammation and repair in the mammalian fetus: A Reappraisal

Hurley, James C.

doi:10.1002/micr.1920151113

Cited by 6 publications

(3 citation statements)

References 37 publications

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“…Gastric wounds made in early-gestation fetal sheep also heal with scar [19] as do intestinal wounds made in fetal rabbits [20]. Scar also forms after wounding fetal nerve tissue [21][22][23], trachea, and myocardium [24][25][26]. These findings are consistent with observations for human fetal surgery in which extensive adhesions have been found following fetal diaphragmatic hernia repair [27].…”

Section: Organ Specificitysupporting

confidence: 69%

Fetal Wound Healing: Current Biology

2003

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The early-gestation fetus heals dermal wounds rapidly and scarlessly. This phenomenon appears to be intrinsic to fetal skin and independent of the intrauterine environment. Unique properties of fetal cells, extracellular matrix, cytokine profile, and gene expression contribute to scarless repair. An intensive research effort has focused on unraveling the mechanisms that underlie scarless fetal wound healing in an attempt to improve the quality of healing in both children and adults.

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Section: Organ Specificitysupporting

confidence: 69%

Fetal Wound Healing: Current Biology

2003

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“…However, when an inflammatory substance was administered in fetuses during the gestation period when scarring does not occur, macrophages were reported to be recruited to the injection sites. 5,6 In addition, in E16 mouse fetuses in which histological cutaneous regeneration is known to occur, macrophages were recruited to the wound surface, but Mac-1-positive activated macrophages were reported to be limited in number. 7 These findings indicate that even at the stage when fetal cutaneous regeneration occurs, inflammatory cells exist and may respond to inflammation.…”

Section: Inflammatory Responsesmentioning

confidence: 99%

Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin

et al. 2012

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Until a certain developmental stage, cutaneous wounds in mammalian fetuses heal rapidly without scars with complete regeneration of the skin. In the process of fetal wound healing, inflammatory responses, granulation proliferation, and scar formation that are observed in adults are not seen. Numerous studies have reported the causes of fetal scarless cutaneous regeneration, including reduced expression of TGF-β1 and higher levels of hyaluronan in the extracellular matrix, from the viewpoints of molecular biology and cellular biology, but the mechanisms are not completely understood. Although a variety of substances that inhibit scar formation have been investigated, currently it is almost impossible for adult cutaneous wounds to heal completely without scars. Except for a few animal species, perfect regeneration after wounding can occur only during the gestation period. By strictly comparing the stages before and after the transition from the regeneration of skin to scarring, it will be possible to investigate the mechanisms of cutaneous regeneration.

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“…hem atology, (2) reproductive biology, (3 ) fetal surgery, (4) vascular biology, and genom ic cloning. (5,6) Sheep are a relatively inexpensive domesticated animal that have several unique anatom ic features.…”

Section: Introduction S H Ee P a R E A W El L-e Sta Bl Is H Ed M O D mentioning

confidence: 99%

Generation of Sheep X (Sheep X Mouse) Heterohybridoma Cell Line Expressing the Beta-1 Integrin Membrane Molecule

He²,

West³

et al. 2000

Hybridoma

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Sheep are an important biological model in such diverse areas as immunology and reproductive biology. The limitation of sheep as an experimental model is the absence of reliable cell lines. To establish cell lines that express functional sheep membrane molecules, we produced a sheep x mouse heterohybridoma by fusion of sheep efferent lymph T cells with the murine myeloma cell line NS1. A cloned heterohybridoma fusion partner was selected by treatment with 8-azaguanine. The resulting cell line HL1/385 was selected for hypoxanthine/aminopterin/thymidine (HAT) sensitivity and growth efficiency. The HL1/385 cell line was used as a back-fusion partner into lectin-stimulated efferent T lymphocytes. The back-fusion approach produced more than 50 heterohybrid cell lines with high growth efficiency. The expression of physiological levels of the sheep beta-1 integrin cell surface molecule on the HT4/6 cell line was stable for months in culture. These results suggest that somatic heterohybrids may provide a reliable source of cell lines for sheep studies in vitro.

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Inflammation and repair in the mammalian fetus: A Reappraisal

Cited by 6 publications

References 37 publications

Fetal Wound Healing: Current Biology

Fetal Wound Healing: Current Biology

Fetal Skin Possesses the Ability to Regenerate Completely: Complete Regeneration of Skin

Generation of Sheep X (Sheep X Mouse) Heterohybridoma Cell Line Expressing the Beta-1 Integrin Membrane Molecule

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